Jacques L. De Reuck, MD, PhD, Department of Neurology, University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium (tel.: +32 9 2404541; fax: +32 9 2404971; e-mail: [email protected]).

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Abstract

Chronic obstructive pulmonary disease (COPD) is a risk factor for cardiovascular disorders and different types of stroke. The present retrospective study investigates whether COPD is also a risk factor for the development of seizures in stroke patients. The study population consisted of 237 patients with stroke-related seizures. The control population was composed of 939 patients, admitted for a stroke between 2002 and 2004 and who did not develop epileptic spells on a follow up of 2 years. The stroke type and aetiology, and the vascular risk factors, including COPD, were compared. The seizure patients were older (P = 0.009) and had more arterial hypertension (P = 0.046) and cardiac-embolic strokes (P = 0.045) than the control group. On logistic regression only partial anterior circulation syndrome/infarct (PACS/I) and COPD (P < 0.001) emerged as independent risk factors for the development of seizures in stroke patients. The occurrence of seizures was not related to the severity of the COPD or to its type of treatment. The present study confirms that seizures occur most frequently in patients with a PACS/I. Although we were unable to demonstrate why COPD is a risk factor for seizures in stroke patients, its frequent associated nocturnal oxygen desaturation seems to be the most plausible explanation. Further prospective are needed to assess the role of COPD as a possible independent risk factor for stroke-related seizures.

References

1 Jousilahti P, Vartainen E, Tuomilehto J, Puska P. Symptoms of chronic bronchitis and risk of coronary disease. Lancet 1996; 348: 567–572.
10.1016/S0140-6736(96)02374-4
CAS PubMed Web of Science® Google Scholar
2 Ryan G, Knuiman MW, Divitini ML, James A, Musk AW, Bartholomew HC. Decline in lung function and mortality: the Busselton health Study. Journal of Epidemiology and Community Health 1999; 53: 230–234.
10.1136/jech.53.4.230
CAS PubMed Web of Science® Google Scholar
3 Curkendall SM, DeLuise C, Jones JK, et al. Cardiovascular disease in patients with chronic obstructive pulmonary disease, Saskatchewan Canada cardiovascular disease in COPD patients. Annals of Epidemiology 2006; 16: 63–70.
10.1016/j.annepidem.2005.04.008
PubMed Web of Science® Google Scholar
4 Strachan DP. Ventilatory function as a predictor of fatal stroke. BMJ 1991; 302: 84–87.
10.1136/bmj.302.6768.84
CAS PubMed Web of Science® Google Scholar
5 Wannamethee G, Shaper G, Ebrahim S. Respiratory function and risk of stroke. Stroke 1995; 26: 2004–2010.
10.1161/01.STR.26.11.2004
CAS PubMed Web of Science® Google Scholar
6 Limburg M, Wijdicks EF, Li H. Ischemic stroke after surgical procedures: clinical features, neuroimaging, and risk factors. Neurology 1998; 50: 895–901.
10.1212/WNL.50.4.895
CAS PubMed Web of Science® Google Scholar
7 Truelsen Th, Prescott E, Lange P, Schnohr P, Boysen G. Lung function and risk of fatal and non-fatal stroke. The Copenhagen City Heart Study. International Journal of Epidemiology 2001; 30: 145–151.
10.1093/ije/30.1.145
CAS PubMed Web of Science® Google Scholar
8 Engstrom G, Hedblad B, Valind S, Janzon L. Increased myocardial infarction and stroke in hypertensive men with reduced lung function. Journal of Hypertension 2001; 19: 295–301.
10.1097/00004872-200102000-00017
CAS PubMed Web of Science® Google Scholar
9 Arboix A, Morcillo C, Garcia-Eroles L, Oliveres M, Massons J, Targa C. Different vascular risk factor profiles in ischemic stroke subtypes: a study from ‘Sagrat Cor Hospital of Barcelona Stroke Registry’. Acta Neurologica Scandinavica 2000; 102: 264–270.
10.1034/j.1600-0404.2000.102004264.x
CAS PubMed Web of Science® Google Scholar
10 Arboix A, Manzano C, Garcia-Eroles A, et al. Determinants of early outcome in spontaneous lobar cerebral hemorrhage. Acta Neurologica Scandinavica 2006; 114: 187–192.
10.1111/j.1600-0404.2005.00533.x
CAS PubMed Web of Science® Google Scholar
11 Van Dijk EJ, Vermeer SE, De Groot JC, et al. Arterial oxygen saturation, COPD, and cerebral small vessel disease. Journal of Neurology, Neurosurgery and Psychiatry 2004; 75: 733–736.
10.1136/jnnp.2003.022012
CAS PubMed Web of Science® Google Scholar
12 Schwarcz TH, Hogan LA, Endean ED, Roitman IT, Kazmers A, Hyde GL. Thromboembolic complications of polycythemia: polycythemia vera versus smokers’ polycythemia. Journal of Vascular Surgery 1993; 17: 518–522.
10.1067/mva.1993.38623
CAS PubMed Web of Science® Google Scholar
13 Chambellan A, Chailleux E, Similowski T, ANTADIR Observatory Group. Prognostic value of the hematocrit in patients with severe COPD receiving long-term oxygen therapy. Chest 2005; 128: 1201–1208.
10.1378/chest.128.3.1201
PubMed Web of Science® Google Scholar
14 Sidney S, Sorel M, Quesenberry CP, DeLuise C, Lanes S, Eisner MD. COPD and incident cardiovascular disease hospitalizations and mortality: Kaiser Permanente Medical Care Program. Chest 2005; 128: 2068–2075.
10.1378/chest.128.4.2068
PubMed Web of Science® Google Scholar
15 Gao L, Lyons AR, Greenfield LJ Jr Hypoxia alters GABA-A receptor function and subunit expression in NT2-N neurons. Neuropharmacology 2004; 46: 318–330.
10.1016/j.neuropharm.2003.09.008
CAS PubMed Web of Science® Google Scholar
16 Murray DM, Ryan CA, Boylan GB, Fitzgerald AP, Connolly S. Prediction of seizures in asphyxiated neonates: correlation with continuous video-electroencephalographic monitoring. Pediatrics 2006; 118: 41–46.
10.1542/peds.2005-1524
PubMed Web of Science® Google Scholar
17 Jennett B. Early traumatic epilepsy. Archives of Neurology 1974; 30: 394–398.
10.1001/archneur.1974.00490350052008
CAS PubMed Web of Science® Google Scholar
18 Bamford J, Sandecock P, Dennis M, et al. Classification and natural history of clinically identifiable subtypes of cerebral infarction. Lancet 1991; 337: 1521–1526.
10.1016/0140-6736(91)93206-O
CAS PubMed Web of Science® Google Scholar
19 De Reuck J, Goethals M, Vonck K, Van Maele G. Clinical predictors of late- onset seizures and epilepsy in patients with cerebrovascular disease. European Neurology 2005; 54: 68–72.
10.1159/000087715
CAS PubMed Web of Science® Google Scholar
20 De Reuck J, De Groote L, Van Maele G. Delayed transient worsening of neurological deficits after ischaemic stroke. Cerebrovascular Diseases 2006; 22: 27–32.
10.1159/000092334
CAS PubMed Web of Science® Google Scholar
21 De Reuck J, Vanhee F, Van Maele G, Claeys I. Magnetic resonance imaging after seizures in patients with an ischemic stroke. Cerebrovascular Diseases 2007; 23: 339–343.
10.1159/000099132
CAS PubMed Web of Science® Google Scholar
22 Thomas SHL. Drug-induced hypertension. Adverse Drug Reaction Bulletin 1993; 159: 559–562.
10.1097/00012995-199304000-00001
Google Scholar
23 Wedzicha JA, Seemungal TA, MacCallum PK, et al. Acute exarcerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels. Thrombosis and Haemostasis 2000; 84: 210–215.
10.1055/s-0037-1613998
CAS PubMed Web of Science® Google Scholar
24 Plywaczewski R, Silwinski P, Nowinski A, Kaminski D, Zielinski J. Incidence of nocturnal desaturation while breathing oxygen in COPD patients undergoing long-term oxygen therapy. Chest 2000; 117: 679–683.
10.1378/chest.117.3.679
CAS PubMed Web of Science® Google Scholar
25 Chaouat A, Weitzenblum E, Kessier R, et al. Outcome of COPD patients with mild daytime hypoxaemia with or without sleep-related oxygen desaturation. European Respiratory Journal 2001; 17: 848–855.
10.1183/09031936.01.17508480
CAS PubMed Web of Science® Google Scholar
26 Levy PA, Guilleminault C, Fagret D, et al. Changes in left ventricular ejection fraction during REM sleep and exercise in chronic obstructive pulmonary disease and sleep apnoea syndrome. European Respiratory Journal 1991; 4: 347–352.
CAS PubMed Web of Science® Google Scholar
27 Oliveira AJ, Zamagni M, Dolso P, Bassetti MA, Gigli GL. Respiratory disorders during sleep in patients with epilepsy: effect of ventilatory therapy on EEG interictal epileptic discharges. Clinical Neurophysiology 2000; 111 (Suppl. 2): S141–S145.
10.1016/S1388-2457(00)00415-6
PubMed Web of Science® Google Scholar

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Volume14, Issue9

September 2007

Pages 989-992

Chronic obstructive pulmonary disease as a risk factor for stroke-related seizures

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Chronic obstructive pulmonary disease as a risk factor for stroke-related seizures

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