Volume 13, Issue 1 pp. 58-63

Original Article

Effect of hypothyroidism on the nitrergic relaxant responses of corpus cavernosal smooth muscle in rabbits

BULENT SARAC,

BULENT SARAC

Departments of Pharmacology and

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MUSTAFA K. YILDIRIM,

MUSTAFA K. YILDIRIM

Departments of Pharmacology and

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IHSAN BAGCIVAN,

Corresponding Author

IHSAN BAGCIVAN

Departments of Pharmacology and

Ihsan Bagcivan md, Cumhuriyet University, School of Medicine, Department of Pharmacology, 58140 Sivas, Turkey. Email: [email protected]Search for more papers by this author

KEMAL KAYA,

KEMAL KAYA

Urology, School of Medicine, Cumhuriyet University, Sivas, Turkey

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HAKAN KILICARSLAN,

HAKAN KILICARSLAN

Urology, School of Medicine, Cumhuriyet University, Sivas, Turkey

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SAHIN YILDIRIM,

SAHIN YILDIRIM

Departments of Pharmacology and

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BULENT SARAC,

BULENT SARAC

Departments of Pharmacology and

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MUSTAFA K. YILDIRIM,

MUSTAFA K. YILDIRIM

Departments of Pharmacology and

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IHSAN BAGCIVAN,

Corresponding Author

IHSAN BAGCIVAN

Departments of Pharmacology and

Ihsan Bagcivan md, Cumhuriyet University, School of Medicine, Department of Pharmacology, 58140 Sivas, Turkey. Email: [email protected]Search for more papers by this author

KEMAL KAYA,

KEMAL KAYA

Urology, School of Medicine, Cumhuriyet University, Sivas, Turkey

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HAKAN KILICARSLAN,

HAKAN KILICARSLAN

Urology, School of Medicine, Cumhuriyet University, Sivas, Turkey

Search for more papers by this author

SAHIN YILDIRIM,

SAHIN YILDIRIM

Departments of Pharmacology and

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First published: 31 January 2006

https://doi.org/10.1111/j.1442-2042.2006.01225.x

Citations: 5

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Abstract

Background: The incidence of hormonal dysfunction as a cause of impotence remains controversial. However, several recent studies have reported evidence of hormonal abnormalities in 25–35% of impotent men. Hypothyroidism has been reported to occur in 6% of impotent men.

Methods: In the present study, we examined nitrergic responses in hypothyroidism in rabbit corpus cavernosum and compared them with controls.

Results: Carbachol-induced relaxation responses and electrical field stimulation (EFS)-induced frequency-dependent relaxations decreased significantly in hypothyroid rabbits. Papaverine and sodium nitroprusside (SNP)-induced relaxation responses did not change significantly in hypothyroid rabbits. The contraction responses of phenylephrine and EFS-induced frequency-dependent contractions were significantly decreased in the hypothyroid group.

Conclusions: We can speculate that the reduction of relaxant responses to EFS and carbachol in hypothyroid rabbits can depend on a decreased release of nitric oxide (NO) from nitrergic nerves and endothelium or a reduction of muscarinic receptor density. Also, decreases in contraction responses may depend on diminished adrenoceptor density.

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Volume13, Issue1

January 2006

Pages 58-63

Effect of hypothyroidism on the nitrergic relaxant responses of corpus cavernosal smooth muscle in rabbits

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References

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Effect of hypothyroidism on the nitrergic relaxant responses of corpus cavernosal smooth muscle in rabbits

Abstract

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