Mono-Unsaturated Metabolites of Valproic Acid in Epileptic Women and Their Neonates
Tsuyoshi Kondo M.D.
Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki
Search for more papers by this authorKoichi Otani M.D.
Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki
Search for more papers by this authorTakayuki Hirano M.D.
Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki
Search for more papers by this authorSunao Kaneko M.D.
Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki
Search for more papers by this authorYutaka Fukushima M.D.
Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki
Search for more papers by this authorTokijiro Sato M.D.
Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki
Search for more papers by this authorYukimitsu Nomura M.D.
*Department of Obstetrics and Gynecology, Hirosaki University School of Medicine, Hirosaki
Search for more papers by this authorYoshihiro Ogawa M.D.
*Department of Obstetrics and Gynecology, Hirosaki University School of Medicine, Hirosaki
Search for more papers by this authorTsuyoshi Kondo M.D.
Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki
Search for more papers by this authorKoichi Otani M.D.
Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki
Search for more papers by this authorTakayuki Hirano M.D.
Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki
Search for more papers by this authorSunao Kaneko M.D.
Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki
Search for more papers by this authorYutaka Fukushima M.D.
Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki
Search for more papers by this authorTokijiro Sato M.D.
Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki
Search for more papers by this authorYukimitsu Nomura M.D.
*Department of Obstetrics and Gynecology, Hirosaki University School of Medicine, Hirosaki
Search for more papers by this authorYoshihiro Ogawa M.D.
*Department of Obstetrics and Gynecology, Hirosaki University School of Medicine, Hirosaki
Search for more papers by this author
References
- 1 Kaneko, S., Fukushima, Y., Sato, T., Nomura, Y., Ogawa, Y., Saito, M., Shinagawa, S. and Yamazaki, S.: Hazards of fetal exposure to antiepileptic drugs: A preliminary report. In: T. Sato and S. Shinagawa (eds.), Antiepileptic drugs and pregnancy. Excerpta Medica, Amsterdam , 132–138, 1984.
- 2 Kaneko, S., Otani, K., Fukushima, Y., Sato, T., Nomura, Y. and Ogawa, Y.: Transplacental passage and half-life of sodium valproate in infants born to epileptic mothers. Br J Clin Pharmac 15: 503–506, 1983.
- 3 Kochen, W., Schneider, A. and Ritz, A.: Abnormal metabolism of valproic acid in fatal hepatic failure. Eur J Pediatr 141: 30–35, 1983.
- 4 Matsuoka, O., Kin, M., Higami, S., Murata, R., Sugita, K., Tsuguhara, T. and Ooura, T.: The interaction between valproate sodium and phenobarbital or pheny-toin. No To Hattatsu 11: 577–583, 1979 (in Japanese).
- 5 Nau, H. and Loscher, W.: Valproic acid and metabolites: pharmacological and toxicological studies. Epilepsia 25: S14–S22, 1984.
- 6 Nau, H., Rating, D., Koch, S., Hauser, I. and Helge, H.: Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers. J Pharmac Exp Ther 219: 768–777, 1981.
- 7 Otani, K.: Risk factors for the increased seizure frequency during pregnancy and puerperium. Folia Psychiat Neurol Jpn 39(1): 33–42, 1985.
