Department of Neuropsychiatry, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto 602, JapanSearch for more papers by this author

Masahiko Mori M.D.,

Masahiko Mori M.D.

Department of Neuropsychiatry, Kyoto Prefectural University of Medicine, Kyoto

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Hiromichi Hashimoto M.D.,

Hiromichi Hashimoto M.D.

Department of Neuropsychiatry, Kyoto Prefectural University of Medicine, Kyoto

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Kenji Fukui M.D.,

Kenji Fukui M.D.

Department of Neuropsychiatry, Kyoto Prefectural University of Medicine, Kyoto

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Tadashi Mori M.D.,

Tadashi Mori M.D.

*Department of Neuropsychiatry, Saiseikai Hospital, Suita

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Tadashi Noto M.D.,

Tadashi Noto M.D.

Department of Neuropsychiatry, Kyoto Prefectural University of Medicine, Kyoto

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Teruo Nakajima M.D.,

Corresponding Author

Teruo Nakajima M.D.

Department of Neuropsychiatry, Kyoto Prefectural University of Medicine, Kyoto

Department of Neuropsychiatry, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto 602, JapanSearch for more papers by this author

First published: June 1987

https://doi.org/10.1111/j.1440-1819.1987.tb00416.x

Citations: 2

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Abstract

Abstract: The effects of 3,4-dihydroxyphenylserine (DOPS), a nonnatural precursor of noradrenaline, on the sleep-wakefulness patterns of rats were studied. When the animals received an intraperitoneal injection of L-erythro-DOPS (200 mg/kg), a significantincrease in slow wave sleep and a tendency to decrease wakefulness were observed during the first 2 hours after the injection. Paradoxical sleep increased 4–8 hours after the treatment. A simultaneous injection of benserazide (20 mg/kg) enhanced these effects. L-threo-DOPS (200 mg/kg, i.p.) had no effect on the sleep-wakefulness patterns. The effects ofDOPS on the concentrations of brain catecholamines and serotonin in rats were also examined. An intraperitoneal injection of L-erythro-DOPS markedly increased the concentration of noradrenaline (probably the d-form) and decreased that of serotonin and dopamine. L-threo-DOPS had no effect on the brain monoamine levels of the rats in the present experimental condition. The effects of L-erythro-DOPS on the neurons containing noradrenaline in the rats were examined by fluorescence histochemistry. Fluorescence in the neuronal perikarya and fibers containing noradrenaline markedly increased in the n. coeruleus, n. paraventricularis and cerebral cortex after an intraperitoneal injection of amino acid. Fibers containing the fluorescence also increased in the second two areas.

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Volume41, Issue2

June 1987

Pages 301-310

Effects of L-Erythro-3, 4-Dihydroxyphenylserine on Sleep-Wakefulness Patterns and Concentrations of Brain Catecholamines and Serotonin in Rats

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Effects of L-Erythro-3, 4-Dihydroxyphenylserine on Sleep-Wakefulness Patterns and Concentrations of Brain Catecholamines and Serotonin in Rats

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