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Effects of Acute and Chronic Ethanol Administration on Amino Acid Metabolism in Rabbit Brain and Blood
Yoshiaki Okamoto M.D.,
Touhei Murayama M.D.,
Motoi Ogata M.D.,
Yoshiaki Okamoto M.D.
Department of Neuropsychiatry, Sapporo Medical College, Sapporo
Search for more papers by this authorTouhei Murayama M.D.
Department of Neuropsychiatry, Sapporo Medical College, Sapporo
Search for more papers by this authorMotoi Ogata M.D.
Department of Neuropsychiatry, Sapporo Medical College, Sapporo
Search for more papers by this authorYoshiaki Okamoto M.D.,
Touhei Murayama M.D.,
Motoi Ogata M.D.,
Yoshiaki Okamoto M.D.
Department of Neuropsychiatry, Sapporo Medical College, Sapporo
Search for more papers by this authorTouhei Murayama M.D.
Department of Neuropsychiatry, Sapporo Medical College, Sapporo
Search for more papers by this authorMotoi Ogata M.D.
Department of Neuropsychiatry, Sapporo Medical College, Sapporo
Search for more papers by this authorSummary
Acute administration of ethanol increased the cerebrocortical amino acids derived through the tricarboxylic acid cycle except for GABA and decreased the plasma alanine, valine, isoleucine, leucine, and phenyla-lanine whereas chronic administration of ethanol caused no significant changes in the cerebrocortical amino acids and increased the plasma glutamic acid, glutamine, glycine, and ornithine, with decreases in taurine and phenylalanine. Result of this experiment suggests that the CNS-depressant effect of ethanol is related to chanPes in the GABA system and increased uptake by the brain of the branched-chain amino acids while the development of tolerance to ethanol is associated with cellular adaptation in the CNS.
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