IMMUNOBIOLOGY OF CHILDHOOD DISEASES
Corresponding Author
DAVID G. JOSE
The Royal Children's Hospital Research Foundation, Melbourne
Immunology Research Fellow, N.H. & M.R.C.
Dr. David Jose, Research Foundation, The Royal Children's Hospital, Melbourne, 3052.Search for more papers by this authorCorresponding Author
DAVID G. JOSE
The Royal Children's Hospital Research Foundation, Melbourne
Immunology Research Fellow, N.H. & M.R.C.
Dr. David Jose, Research Foundation, The Royal Children's Hospital, Melbourne, 3052.Search for more papers by this authorSYNOPSIS
A large part of clinical paediatrics deals with infectious disease, inflammatory conditions, allergy, auto-immune disease and cancer. The immune system plays a critical role in these diseases and in addition presents a perplexing number of conditions arising from defects in the immune system itself. This review seeks to highlight immune mechanisms in selected diseases of children and to explore the clinical value of these mechanisms in terms of diagnostic or therapeutic application. Some of the principles and mechanisms involved in immune defence have been previously considered (Jose, 1973).
References
- Aas, K. (1970). Bronchial provocation tests in asthma. Arch. Dis Childh., 45: 221–229.
- Aase, J. M., Noren, G. R., Reddy, D. V. and St Greme, J. W. (1972). Mumps-virus infection pregnant women and the immunologic response of their offspring. New Engl. J Med., 286: 1379–1382.
- Ackerman, B. D. (1969). Congenital Syphilis: Observations on laboratory diagnosis of intrauterine infection. J Ped., 74: 459–462.
- Alford, C. A., Schaefer, J. and Blankenship, W. J. (1967). A correlative immunologic microbiologic and clinical approach to the diagnosis of acute and chronic infections in newborn infants, New. Eng. J Med., 277: 437–449.
- Amman, A. J. and Hong, R. (1970). Selective IgA deficiency and autoimmunity. Clin. Exp Immunol., 7: 833–835.
- Anderson, C. M., Gracey, M. and Burke, V. (1972). Coeliac disease some still controversial aspects, Arch. Dis Childh., 47: 292–298.
- Andres, G. A., Accinni, L. and Hsu, K. L. (1966). Electron microscopic studies of human glomerulo-nephritis with ferritin-conjugated antibody: localisation of antigen-antibody complexes in glomerular structures of patients with glomerulonephritis. J. Exp Med., 123: 399–412.
-
August, C. S.,
Levey, R. H.,
Berkel, A. I. and
Rosen, F. S. (1970). Establishment of immunological competence in a child with congenital thymic aplasia by a graft of fetal thymus.
Lancet, i: 1080–1083.
10.1016/S0140-6736(70)92755-8 Google Scholar
- Baldwin, D. S., Lowenstein, J. and Rothfield, N. F. (1970). Clinical course of the proliferative and membraneous forms of lupus nephritis. Ann. Intern Med., 73: 929–942.
- Bazaral, M., Orgel, H. A. and Hamburger, R. N. (1971). IgE levels in normal infants and mothers and an inheritance hypothesis. J Immunol., 107: 794–801.
- Behan, P. O., Lowenstein, L. M., Stilmant, M. and San, D. S. (1973). Landry-Guillain-Barré-Strohl syndrome and immune-complex nephritis. Lancet, i: 850–852.
- Bergsma, D., and Good, R. A. (1968). Immunological Deficiency Diseases in Man. Birth Defects Original Article Series. The National Foundation — March of Dimes, Vol. 4., New York .
- Bronsky, E. and Ellis, E. F. (1969). Inhalation bronchial challenge testing. Ped. Clin. N Amer., 16: 85–94.
- Bruton, O. C. (1968). The discovery of agamma-globulinaemia. In Bergsma, D. and Good, R. A. Immunologic Deficiency Diseases in Man. Birth Defects Original Article Series, Vol. IV. The National Foundation — March of Dimes, New York , 2–8.
-
Choi, Y. S.,
Biggar, W. D. and
Good, R. A. (1972). Biosynthesis and secretion of immunoglobulins by peripheral blood lymphocytes in severe hypogammaglobulinaemia.
Lancet, i: 1149–1151.
10.1016/S0140-6736(72)91374-8 Google Scholar
- Christian, C. L. (1969). Immune complex disease. New. Eng. J Med., 280: 878–884.
- Christian, C. L. and Phillips, P. E. (1973). Viruses and autoimmunity. Amer. J Med., 54: 611–620.
- Cooper, M. D., Faulk, W. P., Fudenberg, H. H., Good, R. A., Hitzig, W., Kunkel, H., Rosen, F. S., Seligmann, M., Soothill, J. and Wedgwood, R. J. (1973). Classification of primary immunodeficiences. New. Eng. J Med., 288: 966–967.
- Davies, P. A. (1971). Bacterial infection in the fetus and newborn. Arch. Dis Childh., 46: 1–27.
- Dayan, A. D. and Stokes, M. I. (1972). Immune complexes and visceral deposits of measles antigens in subacute sclerosing panencephalitis. Bri. Med J., ii: 374–376.
- Dayan, A. D. and Stokes, M. (1973). Rapid diagnosis of encephalitis by immunofluorescent examination of cerebrospinal fluid cells. Lancet, i: 177–179.
- Dent, P. B., Gabrielsen, A. E., Cooper, M. D., Peterson, R. D. A. and Good, R. A. (1969). The secondary immunologic deficiency diseases associated with lymphoproliferative disorders. In P. A. Miescher and H. J. Muller-Eberhard Textbook of Immunopathology. Grave and Stratton. N.Y. , 385–405.
-
Desmyter, J.,
Liu, W. T. and
Van den Berghe, H. (1973). In Intrauterine Infections (Ciba Foundation Symposium 10). Edited by K. Elliott and
J. Knight Amsterdam Elsevier, Excerpta Medica,
North Holland
, 101.
10.1002/9780470719930.ch7 Google Scholar
- Di George, A. M. (1968). Congenital absence of thymus and its immunological consequences: occurrence with congenital hypoparathyroidism. In Immunologic Deficiency Diseases in Man D. Bergsma and R. A. Good, Editors, Birth Defects, Original Article Series, The National Foundation — March of Dimes. New York , Vol. 4, 116–123.
- Dixon, F. J., Wilson, C. B. and Marquardt, H. (1971). Immunology of glomerulonephritis. Progr in Immunology, 1: 681–687.
- Dudding, B. A. and Ayoub, E. M. (1968). Persistence of streptococcal group A antibody in patients with rheumatic valve disease. J. Exp Med., 128: 1081–1098.
- Dudley, F. J., Fox, R. A., Sherlock, S. (1972). Cellular immunity and hepatitis associated, Australia antigen liver disease Lancet, i: 723–726.
- Dudgeon, J. A. (1971). Cytomegalovirus infection. Arch. Dis Childh., 46: 581–583.
- Faulk, P., Awdeh, Z. L., Bengoa, J., Demaeyer, E. M., Dixon, H., Edsall, G., Goodman, H. C., Hopwood, B. E. C., Jose, D. G., Keller, W. D. E., Rodrigues, K., Mata, L. J., McGregor, I. A., Miecher, P. A., Rowe, D. S., Taylor, C. E., Torrigiani, G. (1972). A survey of nutritional-immunological interactions. Bull. Wld. Hlth Org., 46: 537–546.
- Freier, S. and Berger, H. (1973). Disodium chromoglycate in gastrointestinal protein intolerance. Lancet, i: 913–915.
- Frost, M. (1973). Chromoglycate in aphthous stomatitis. Lancet, ii: 389.
- Fudenberg, H. H., Good, R. A., Goodman, H. C., Hitzig, W., Kunkel, K. G., Roitt, I. M., Rosen, F. S., Rowe, D. S., Seligmann, M., Soothill, J. R. (1971). Primary immunodeficiencies. Report of a World Health Organization Committee Pediatrics, 47: 927–946.
- Gatti, R. A. and Good, R. A. (1970). The immunological deficiency diseases. Med. Clin. Nth Amer., 54: 281–297.
-
Gatti, R. A.,
Meuwissen, H. J.,
Allen, H. D.,
Hong, R. and
Good, R. A. (1968). Immunological reconstitution of sex-linked lymphopenic immunological deficiency.
Lancet, ii: 1366–1369.
10.1016/S0140-6736(68)92673-1 Google Scholar
- Gatti, R. A., Platt, N., Pomerace, H. H., Hong, R., Langer, L. O., Kay, H. E. M. and Good, R. A. (1969). Hereditary lymphopenic agammaglobulinaemia associated with a distinctive form of short-limbed dwarfism and ectodermal dysplasia. J Pediatrics, 75: 675–683.
-
Giblet, E. R.,
Anderson, J. E.,
Cohen, F.,
Pollara, B.,
Meuwissen, H. J. (1972). Adenosine deaminase deficiency in two patients with severely impaired cellular immunity.
Lancet, ii: 1067–1069.
10.1016/S0140-6736(72)92345-8 Google Scholar
- Gitlin, D. and Biasucci, A. (1969). Development of γG γA, γM, β/1C/β1A, Cl-esterase inhibitor, ceruloplasmin, transferrin, hemopein, haptoglobin, fibrinogen, plasminogen, α 1-antitrypsin, orosomucoid lipoprotein β2 macroglobulin and prealbumin in the human conceptus, J. Clin Invest., 48: 1433–1446.
- Gocke, D. J. (1971). Fulminant hepatitis treated with serum containing antibody to Australia antigen. New. Eng. J Med., 284: 919.
- Gocke, D. J., Hsu, K., Morgan, T. J. (1971). Vasculitis in association with Australia antigen. J. Exp Med., 134, (Supl.): 3305–3365.
- Goldstein, G. and Hoffman, W. W. (1969). Endocrine function of the thymus affecting neuromuscular transmission. Clin. exp Immunol., 4: 181–193.
- Good, R. A., Finstad, J. and Gatti, R. A. (1970). Bulwarks of the Bodily Defence. In: Infectious Agents and Host Reactions. S. Mudd, W. B. Saunders. Phil., 76–114.
- Griscelli, C., Desmonts, G., Gny, B. and Frommel, D. (1973). Congenital toxoplasmosis. Fetal synthesis of oligoclonal immunoglobulin G intrauterine infection. J Pediat., 83: 20–26.
- Gutterman, J. U., Mauligit, G., McBride, C., Frei, E. III., Freireich, E. J. and Hersh, E. M. (1973). Active immunotherapy with B.C.G for recurrent melanoma Lancet, i: 1208–1212.
- Harris, O. D., Cooke, W. T., Thomson, H. and Waterhouse, J. A. H. (1967). Malignancy in adult coeliac disease and idiopathic steatorrhoea. Amer. J Med., 42: 899–912.
- Hogarth-Scott, R. S., McNicol, K. N., Williams, H. E. and Johanson, S. G. O. (1973). Diagnosis of allergy in vitro. A comparison between skin sensitivity testing and serum levels of specific IgE antibody in children. Med. J Aust., i: 1293–1297.
- Hong, R., Gatti, R. A., Rathbun, J. C. and Good, R. A. (1970). Thymic hypoplasia and thyroid dysfunction. New Eng. J Med., 282: 470–474.
- Hoyer, J. R., Cooper, M. D., Gabrielsen, A. E. and Good, R. A. (1968). Lymphopenic forms of congenital immunological deficiency diseases. Medicine, 47: 201–226.
- Johnson, J. S., Vaughan, J. H., Hench, P. K. and Blomgren, S. E. (1973). Rheumatoid arthritis, 1970–72. Ann. Intern. Med., 78: 937–953.
- Jose, D. G. (1973). Mechanisms of Immune Defence. Austr. Paediat. J.
- Jose, D. G. (1973). Immunobiology of the cancer patient. Leading article. Med. J Austr., i: 622–624.
- Jose, D. G., Barnes, G., Rossiter, E. J. R., Myers, N. A. and Fitzgerald, M. G. (1974). Reconstitution of cellular immune function in a child with thymic aplasia by foetal thymus grafting. Aust. N.Z. J. Med., in press.
- Jose, D. G., Barry, H., Goldblatt, C., Penfold, J. and Welch, J. S. (1970). Heart-reactive antibody serum enzymes and isoenzymes in the diagnosis of acute rheumatic fever, Aust. Ann Med., 19: 215–219.
- Jose, D. G., Gatti, R. A. and Good, R. A. (1971). Eosinophilia with pneumocystis carinii pneumonia in immune deficiency syndromes. J Paediat., 79: 748–754.
- Jose, D. G. and Good, R. A. (1971). Iridocyclitis and pauciarticular juvenile rheumatoid arthritis. J Paediat., 78: 910–911.
- Jose, D. G. and Sheshadri, R. (1974). The role of circulating immune complexes in blocking host cellular immunity to neuroblastoma in children. Aust. N.Z. J Med., 4: 104.
- Jose, D. G., Welch, J. S. and Doherty, R. L. (1970). Humoral and cellular immune responses to streptococci influenza and other antigens in Australian Aboriginal children, Aust. Paediat J., 6: 192–202.
- Kaplan, M. H. and Meyeserian, M. (1962). An immunological cross-reaction between group-A streptococcal cells and human heart tissue. Lancet, i: 707–710.
- Knowles, M., Saunders, M., Currie, S., Walton, J. N. and Field, E. J. (1969). Lymphocyte transformation in the Guillain-Barré Syndrome. Lancet, ii: 1168–1170.
- Koffler, D., Agnello, V. and Thorburn, R. (1971). Systemic lupus erythematosis: prototype of immune complex nephritis in man. J. Exp. Med. (Suppl.): 134: 169–179.
- Kretschmer, R., Say, B., Brown, D. and Rosen, F. S. (1968). Congenital aplasia of the thymus gland (Di George's Syndrome), New Eng. J Med., 279: 1295–1301.
- Lawrence, H. S. (1968). Transfer factor. Adv Immunology., 11: 195–258.
-
Leading Article (1972). What's new in SSPE
Lancet, ii: 263–264.
10.1016/S0140-6736(72)90653-8 Google Scholar
- Leading Article (1973). Intrauterine infections: Problems and prevention. Lancet, i: 868–869.
- Leading Article (1973). CMI in the C.N.S. Lancet, ii: 541–542.
- Leading Article (1973). Macrophage electrophoretic migration test for cancer. Nature, 244: 130–131.
- Levin, A. S., Spitler, L. E., Stites, D. P. and Fudenberg, H. H. (1970). Wiskott Aldrich Syndrome a genetically determined cellular immunologic deficiency: Clinical and laboratory responses to therapy with transfer factor Proc, Nat. Acad. Sci. (U.S.A.), 67: 821–828.
- Lindblad, J. H. and Farr, R. S. (1961). The incidence of positive intradermal reactions and the demonstration of skin sensitising antibody to extracts of ragweed and dust in humans without history of rhinitis or asthma. J Allergy., 32: 392–401.
- Lodmell, D. L., Niwa, A., Hayashi, K. and Notkins, A. L. (1973). Prevention of cell to cell spread of herpes simplex virus by leukocytes. J. Exp Med., 137: 706–720.
-
Lurie, L. and
Duma, R. J. (1970). Opportunistic infections of the lungs.
Human Pathology., 1: 233–257.
10.1016/S0046-8177(70)80037-5 Google Scholar
- Mackay, I. R. (1969). Autoimmune disease. Med. J Austr., 1: 696–699.
- McLaughlin, J. F., Schaller, J. and Wedgewood, R. A. (1973). Arthritis and immunodeficiency. J Pediatrics, 81: 801–803.
- Marcolongo, R. and DiPaolo, N. (1973). Fetal thymic transplant in patients with Hodgkin's disease. Blood, 41: 625–633.
-
Matthews, T. S. and
Soothill, J. F. (1970). Complement activation after milk feeding in children with cows milk allergy.
Lancet, ii: 893–895.
10.1016/S0140-6736(70)92068-4 Google Scholar
- Notkins, A. L. (1971). Infectious virus-antibody complexes: interaction with anti-immunoglobulins complement and rheumatoid factor, J. Exp. Med., (Suppl.), 134: 41S–51S.
- Phelan, P. D., Landau, L. I. and Williams, H. E. (1973). Lung disease associated with infantile agammaglobulinaemia. Austr. Paed J., 9: 147–151.
- Pincus, T., Schur, P. H. and Rose, J. A. (1969). Measurement of Serum DNA — binding activity in systemic lupus erythematous. New Eng. J Med., 281: 701–705.
- Remington, J. S. (1969). The present status of the IgM-fluorescent antibody technique in the diagnosis of congenital toxoplasmosis. J Paediatrics, 75: 1116–1124.
- Rocklin, R. E., Sheremata, W. A., Feldman, R. G., Kies, M. W. and David, J. R. (1971). The Guillain-Barré syndrome and multiple sclerosis. In-vitro cellular responses to nervous tissue antigens. New Eng. J Med., 284: 803–808.
- Rose, G. A. and Spencer, H. (1957). Polyarteritis nodosa. Quart. J Med., 26: 43–81.
- Shmerling, D. H. and Shiner, M. (1970). The response of the intestinal mucosa to the intraduodenal instillation of gluten in patients with coeliac disease during remission (Abst.) Acta Paediatrica Scand., 59: 461.
- Smith, H., Bannester, B. and O'Shea, M. J. (1973). Cerebrospinal fluid immunoglobulins in meningitis. Lancet, ii: 591–593.
- South, M. A., Cooper, M. D., Wollheim, F. A. and Good, R. A. (1968). The IgA System. II The clinical significance of IgA deficiency: studies of patients with agammaglobulinaemia and ataxia telangiectasia. Amer. J Med., 44: 168–179.
- Steinberg, A. D., Kallreider, H. B., Staples, P. J. (1971). Cyclophosphamide in lupus nephritis: a controlled trial. Ann. Intern Med., 75: 165–171.
- Sterlz, J. and Silverstein, A. M. (1967). Development aspects of immunity. Adv Immunol., 6: 337–459.
- Stiehm, E. R., Amman, A. J., Barnett, E. V., Craddock, C. G., Fudenberg, H. H. and Lawlor, G. J. (1972). Diseases of cellular immunity. Ann. Intern Med., 77: 101–166.
-
Taylor, B.,
Norman, A. P.,
Orgel, H. A.,
Stokes, C. R.,
Turner, M. W. and
Soothill, J. F. (1973). Transient IgA deficiency and pathogenesis of infantile atopy.
Lancet, ii: 111–113.
10.1016/S0140-6736(73)93060-2 Google Scholar
-
Townley, R. R. W.,
Bhathal, P. S.,
Cornell, H. J. and
Mitchell, J. D. (1973). Toxicity of wheat gliadin fractions in coeliac disease.
Lancet, i: 1363–1365.
10.1016/S0140-6736(73)91679-6 Google Scholar
- Wall, A. J., Douglas, A. P., Booth, C. C. and Pearse, A. G. E. (1970). Response of the jejunal mucosa in adult coeliac disease to oral predni-solone. Gut., 11: 7–13.
- Wallace, S. L., Diamond, H. and Kaplan, D. (1972). Recent advances in rheumatic diseases: The connective tissue diseases other than rheumatoid arthritis 1970 and 1971. Ann. Intern. Med., 77: 455–464.
- Walton, K. W. (1968). Hypersensitivity and infection in the pathogenesis of the rheumatoid diseases. Int. Rev. exp Path., 6: 322–374.
-
Weiner, A. S.,
Zieve, T. and
Fries, J. H. (1936). The inheritance of allergic disease.
Ann Eugenics, 7: 141–149.
10.1111/j.1469-1809.1936.tb02135.x Google Scholar
- Weiss, D. W. (1971). Immunological parameters of host-tumour relationships. Academic Press N.Y. .
- Wiederholt, W. C., Mulder, D. W. and Lambert, E. H. (1964). The Landry-Guillain-Barreé-Strohl syndrome or polyradiculo-neuropathy: historical review report on 97 patients and present concepts, Mayo Clin Proc., 39: 427–451.
- Wiggelinkhuizen, J., Kaschula, R. O. C., Uys, C. J., Kuijten, R. H., Dole, J. (1973). Congenital syphilis and glomerulonephritis with evidence for immune pathogenesis. Arch. Dis Child., 48: 375–381.
- Wybran, J. and Fudenberg, H. H. (1972). Cellular immunity to platelets in idiopathic thrombocytopenic purpura. Blood, 40: 856–861.
- Valdimarsson, H., Wood, C. B. S., Hobbs, J. R. and Holt, P. J. L. (1972). Immunological features in a case of chronic granulomatous candidiasis and its treatment with transfer factor. Clin. exp Immunol., 11: 151–163.
- Ziegenfuss, J. F., Miller, J., Rossman, D. (1971). Rheumatoid factor and Australia antigen. New Eng. J Med., 284: 1104.