Frequency distribution of cytokine gene polymorphisms in the healthy North Indian population
G. Kaur
Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
Search for more papers by this authorC. C. Rapthap
Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
Search for more papers by this authorN. Kumar
Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
Search for more papers by this authorS. Kumar
Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
Search for more papers by this authorS. Neolia
Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
Search for more papers by this authorCorresponding Author
N. K. Mehra
Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
Narinder K. MehraDepartment of Transplant Immunology andImmunogeneticsAll India Institute of Medical SciencesAnsari NagarNew Delhi 110029IndiaTel: (91 11) 26588588Fax: (91 11) 26588663e-mail: [email protected]Search for more papers by this authorG. Kaur
Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
Search for more papers by this authorC. C. Rapthap
Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
Search for more papers by this authorN. Kumar
Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
Search for more papers by this authorS. Kumar
Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
Search for more papers by this authorS. Neolia
Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
Search for more papers by this authorCorresponding Author
N. K. Mehra
Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
Narinder K. MehraDepartment of Transplant Immunology andImmunogeneticsAll India Institute of Medical SciencesAnsari NagarNew Delhi 110029IndiaTel: (91 11) 26588588Fax: (91 11) 26588663e-mail: [email protected]Search for more papers by this authorAbstract
The allelic and genotype frequencies corresponding to 22 single nucleotide polymorphisms (SNPs) in 13 cytokine genes interleukin (IL) 1-α (T/C −889), IL1-β (C/T −511, T/C +3962), IL12 (C/A −1188), interferon-γ (A/T UTR 5644), transforming growth factor-β (C/T codon 10, G/C codon 25), tumour necrosis factor-α (G/A −308, G/A −238), IL2 (T/G −330, G/T +160), IL4 (T/G −1098, T/C −590, T/C −33), IL6 (G/C −174, G/A nt 565), IL10 (G/A −1082, C/T −819, C/A −592), IL1R (C/T pst11970), IL1RA (T/C mspa111100) and IL4RA (G/A +1902) were determined in 130 healthy North Indian subjects. All genomic typings were performed with polymerase chain reaction with sequence-specific assays. An analysis of the allelic and haplotype frequencies in the North Indian population showed a good fit with the Hardy–Weinberg equilibrium for most of the SNPs. The data can be used for anthropological comparisons, as well as for association studies with different diseases and for use in transplant situations involving acute and chronic rejection.
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