Polymorphisms of human leucocyte antigen genes in Maonan people in China
S. Ogata
Department of Genetic Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Search for more papers by this authorL. Shi
Institute of Medical Biology, Chinese Academy of Medical Science, Kunming, China
The contributions of Saeko Ogata and Li Shi are equal and the order of authorship is arbitrary.
Search for more papers by this authorM. Matsushita
Institute for Biotechnology Research, Wakunaga Pharmaceutical Co., Hiroshima, Japan
Search for more papers by this authorL. Yu
Institute of Medical Biology, Chinese Academy of Medical Science, Kunming, China
Search for more papers by this authorX. Q. Huang
Institute of Medical Biology, Chinese Academy of Medical Science, Kunming, China
Search for more papers by this authorL. Shi
Institute of Medical Biology, Chinese Academy of Medical Science, Kunming, China
Search for more papers by this authorH. Sun
Institute of Medical Biology, Chinese Academy of Medical Science, Kunming, China
Search for more papers by this authorJ. Ohashi
Institute for Biotechnology Research, Wakunaga Pharmaceutical Co., Hiroshima, Japan
Search for more papers by this authorM. Muramatsu
Department of Genetic Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Search for more papers by this authorCorresponding Author
K. Tokunaga
Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Prof. Jia You ChuInstitute of Medical BiologyChinese Academy of Medical ScienceKunming 650118ChinaTel: 86-871-8334326Fax: 86-871-8334483e-mail: [email protected] andProf. Katsushi TokunagaDepartment of Human GeneticsGraduate School of MedicineUniversity of TokyoTokyo 113-0033JapanTel: +81-3-5841-3692Fax: +81-3-5802-2907e-mail: [email protected]Search for more papers by this authorCorresponding Author
J. Y. Chu
Institute of Medical Biology, Chinese Academy of Medical Science, Kunming, China
Prof. Jia You ChuInstitute of Medical BiologyChinese Academy of Medical ScienceKunming 650118ChinaTel: 86-871-8334326Fax: 86-871-8334483e-mail: [email protected] andProf. Katsushi TokunagaDepartment of Human GeneticsGraduate School of MedicineUniversity of TokyoTokyo 113-0033JapanTel: +81-3-5841-3692Fax: +81-3-5802-2907e-mail: [email protected]Search for more papers by this authorS. Ogata
Department of Genetic Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Search for more papers by this authorL. Shi
Institute of Medical Biology, Chinese Academy of Medical Science, Kunming, China
The contributions of Saeko Ogata and Li Shi are equal and the order of authorship is arbitrary.
Search for more papers by this authorM. Matsushita
Institute for Biotechnology Research, Wakunaga Pharmaceutical Co., Hiroshima, Japan
Search for more papers by this authorL. Yu
Institute of Medical Biology, Chinese Academy of Medical Science, Kunming, China
Search for more papers by this authorX. Q. Huang
Institute of Medical Biology, Chinese Academy of Medical Science, Kunming, China
Search for more papers by this authorL. Shi
Institute of Medical Biology, Chinese Academy of Medical Science, Kunming, China
Search for more papers by this authorH. Sun
Institute of Medical Biology, Chinese Academy of Medical Science, Kunming, China
Search for more papers by this authorJ. Ohashi
Institute for Biotechnology Research, Wakunaga Pharmaceutical Co., Hiroshima, Japan
Search for more papers by this authorM. Muramatsu
Department of Genetic Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Search for more papers by this authorCorresponding Author
K. Tokunaga
Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Prof. Jia You ChuInstitute of Medical BiologyChinese Academy of Medical ScienceKunming 650118ChinaTel: 86-871-8334326Fax: 86-871-8334483e-mail: [email protected] andProf. Katsushi TokunagaDepartment of Human GeneticsGraduate School of MedicineUniversity of TokyoTokyo 113-0033JapanTel: +81-3-5841-3692Fax: +81-3-5802-2907e-mail: [email protected]Search for more papers by this authorCorresponding Author
J. Y. Chu
Institute of Medical Biology, Chinese Academy of Medical Science, Kunming, China
Prof. Jia You ChuInstitute of Medical BiologyChinese Academy of Medical ScienceKunming 650118ChinaTel: 86-871-8334326Fax: 86-871-8334483e-mail: [email protected] andProf. Katsushi TokunagaDepartment of Human GeneticsGraduate School of MedicineUniversity of TokyoTokyo 113-0033JapanTel: +81-3-5841-3692Fax: +81-3-5802-2907e-mail: [email protected]Search for more papers by this authorAbstract
We examined human leucocyte antigen (HLA) gene polymorphisms in the Maonan people from southern China. HLA-A, -B and -DRB1 alleles were determined in 108 healthy unrelated Maonan individuals by the polymerase chain reaction-Luminex method, and haplotype frequencies for HLA-A, -B and -DRB1 loci were estimated. The most frequent HLA-A alleles were A*1101 (35.2%), A*0203 (17.6%), A*0207 (13.4%) and A*2402 (13.4%); HLA-B alleles were B*1301(19.9%), B*1502 (14.8%), B*4601 (13.4%) and B*4001 (13.4%); HLA-DRB1 alleles were DRB1*1202 (17.1%), DRB1*1602 (13.0%) and DRB1*1401 (10.7%). The most common haplotypes were A*0207-B*4601 (10.6%), A*1101-B*1301 (10.0%), A*1101-B*4001 (8.4%), B*1502-DRB1*1202 (12.0%), B*4601-DRB1*1401 (5.8%), A*1101-B*1502-DRB1*1202 (7.1%) and A*0207-B*4601-DRB1*1401 (5.3%), profiles that are also found in populations from the southern region of East Asia. Phylogenetic and principal component analyses revealed that the Maonan people belong to the southeastern Asian group and are most closely related to the Buyi people.
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