The effect of experimental fascioliasis on the pharmacokinetics of antipyrine and sulphadimidine in desert sheep

Corresponding Author

H. A. ELSHEIKH

Department of Veterinary Medicine, Pharmacology and Toxicology, University of Khartoum, PO Box 32, Khartoum North, Sudan

Hatim Ali Elsheikh, Department of Biomedical Sciences, Faculty of Biomedical and Health Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor Darul Ehsan, Malaysia.Search for more papers by this author

B. H. ALI,

B. H. ALI

Desert and Marine Environment Research Center, U.A.E. University, PO Box 17777, Al-Ain, United Arab Emirates

Search for more papers by this author

H. A. ELSHEIKH,

Corresponding Author

H. A. ELSHEIKH

Department of Veterinary Medicine, Pharmacology and Toxicology, University of Khartoum, PO Box 32, Khartoum North, Sudan

B. H. ALI,

B. H. ALI

Desert and Marine Environment Research Center, U.A.E. University, PO Box 17777, Al-Ain, United Arab Emirates

Search for more papers by this author

First published: 14 March 2007

https://doi.org/10.1111/j.1365-2885.1997.tb00091.x

About

PDF

Tools

Share a link

Email
Wechat
Bluesky

Abstract

Healthy adult male desert sheep were experimentally infected with Fasciola gigantica, to investigate the influence of experimental fasciolasis on the pharmacokinetics of antipyrine and sulphadimidine. Each animal received 500 metacercariae orally. The experimental infection was confirmed histologically, by detection of Fasciola eggs in faeces and by measuring the activities of the enzymes sorbitol dehydrogenase (SD), glutamate dehydrogenase (GD) and aspartate aminotransferase (AST) in plasma during the course of the disease. Changes in the pharmacokinetics of antipyrine and sulphadimidine were reported in the experimentally infected animals. Significant prolongation of antipyrine half life was observed 16 weeks after infection. The half-life of sulphadimidine was also significantly prolonged 5, 9 and 16 weeks after infection. Clearance of the sulphonamide was decreased significantly 5 and 9 weeks after infection and it regained its pre-infection value 16 weeks after infection.

References

Baggot, J. D. (1977) Principles of drug disposition in domestic animals. W. B. Saunders, Philadelphia .
Google Scholar
Bratton, A. C. & Marshall, E. K. (1939) A new coupling component for sulphanilamide determination. Journal of Biological Chemistry. 128, 537–550.
CAS Web of Science® Google Scholar
Brodie, B. B., Axelrod, J., Soberman, R. & Levy, B. B. (1949) The estimation of antipyrine in biological materials. Journal of Biological Chemistry. 179, 25–29.
CAS PubMed Web of Science® Google Scholar
Butlers, J. T. M., Zysset, T. & Reichen, J. (1993) Metabolism of antipyrine in vivo in two models of liver Cirrhosis. Biochemical Pharmacology, 46, 983–991.
10.1016/0006-2952(93)90662-G
PubMed Web of Science® Google Scholar
Burrows, G. E., Rasler, G., Borary, J. C. & Egerton, R. (1991) The effect of fascioliasis on drug disposition in sheep. Acta Veterinaria Scandinavica 87 (suppl.). 245–246.
Google Scholar
Duwel D. & Reisenleiter, R. (1984) Fasciola hepatica: Coproscopic diagnosis compared with the worm burden in the sheep. Helminthologia, 21, 151–159.
Google Scholar
Elsheikh, H. A., Ali, B. H., Homeida, A. M., Lufti, A. A. A. & Hapke, H. J. (1992) The effects of fascioliasis on the activities of some drug-metabolizing enzymes in desert sheep. British Veterinary Journal, 148, 249–257.
10.1016/0007-1935(92)90048-6
CAS PubMed Web of Science® Google Scholar
Facino, R. M., Carini, M. & Genchi, C. (1984) Impaired in vitro metabolism of the flukicidal agent nitroxinyl by hepatic microsomal cytochrome P-450 in bovine fascioliasis. Toxicology Letters, 20, 231–236.
10.1016/0378-4274(84)90153-X
CAS PubMed Web of Science® Google Scholar
Ford, E. J. H. (1967) Activity of sorbitol dehydrogenase (S. D) in the serum of sheep and cattle with liver damage. Journal of Comparative Pathology, 77, 405–411.
10.1016/0021-9975(67)90025-4
CAS PubMed Web of Science® Google Scholar
Ford, E. J. H. & Boyd, J. W. (1962) Cellular damage and changes in biliary excretion in a liver lesion of cattle. Journal of Pathology and Bacteriology, 83, 39–47.
10.1002/path.1700830106
CAS PubMed Web of Science® Google Scholar
Gad, S. & Weil, C. S. (1986) Statistics and experimental design for toxicologists. The Telford Press, Caldwell , New Jersey .
Google Scholar
Gibaldi, M. & Perrier, D. (1982) Pharmacokinetics, 2nd edn. Marcel Dekker Inc., New York.
10.1201/b14095
Web of Science® Google Scholar
Howden, C. W. (1989) Drug metabolism in liver diseases. Pharmacology and Therapeutics, 40, 439–474.
10.1016/0163-7258(89)90088-0
CAS PubMed Web of Science® Google Scholar
Haroun, E. M. (1975) Studies On Bovine Fascioliasis In Sudan With Particular Reference To The White Nile Province. Mvsc. Thesis, University Of Khartoum.
Google Scholar
Kato, R. (1977) Drug metabolism under pathological and abnormal physiological states. Xenobiotica, 7, 25–92.
10.3109/00498257709036242
CAS PubMed Web of Science® Google Scholar
Kuttler, K. I. & Marble, D. W. (1960) Serum protein changes in Lambs with naturally acquired nematode infections. American Journal of Veterinary Research, 21, 445–448.
CAS PubMed Web of Science® Google Scholar
Loft, S. T. (1990) Metronidazole and antipyrine as probes for the study of foreign compound metabolism. Pharmacology and Toxicology, 66, (Suppl. VI), 1 - 31.
10.1111/j.1600-0773.1990.tb01611.x
CAS PubMed Google Scholar
Nawaz, M. (1983) Some physiological factors affecting disposition of sulphadimidine in sheep during summer and winter. Pakistan Veterinary Journal, 3, 137–140.
CAS Google Scholar
Reitman, S. & Frankel, S. (1957) A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. American Journal of Clinical Pathology, 28, 56–63.
10.1093/ajcp/28.1.56
CAS PubMed Web of Science® Google Scholar
Sewell, M. M. H. (1967) Serum enzyme activities in acute ovine fascioliasis. Veterinary Record, 80, 577–578.
Web of Science® Google Scholar
Sinclair, K. B. (1975) The resistance of sheep to Fasciola hepatica. Studies on the pathophysiology of challenge infections. Research in Veterinary Science, 19, 296–303.
CAS PubMed Web of Science® Google Scholar
Sotaniemi, E. A., Pelkonen, R. O., Mokka, R. E., Huttunen, R. & Viljakainen, E. (1977) Impairment of drug metabolism in patients with liver cancer. European Journal of Clinical Investigation, 7, 269–274.
10.1111/j.1365-2362.1977.tb01604.x
CAS PubMed Web of Science® Google Scholar
Tekawni, B. L., Shukla, O. P. & Ghatak, S. (1988) Altered drug metabolism in parasitic diseases. Parasitology Today, 4, 4–10.
10.1016/0169-4758(88)90047-6
PubMed Web of Science® Google Scholar
Tufenkji, A. E., Alvinerie, M., Pineau, T., Boulard, C. & Galtier, P. (1988) Incidence of a subclinical fascioliasis on antipyrine clearance and metabolite excretion in sheep. Xenobiotica, 18, 357–364.
10.3109/00498258809041671
CAS PubMed Web of Science® Google Scholar
Vesell, E. S. (1979) The antipyrine test in clinical pharmacology: Conceptions and misconceptions. Clinical Pharmacology and Therapeutics, 26, 275–286.
10.1002/cpt1979263275
CAS PubMed Web of Science® Google Scholar
Wojcicki, J., Sulikowski, T., Wojcicki, M., Drozdzik, M., Gawronska-Szklara, G., Barcew-Wisznieaska, B., Skowron, J. & Rozewicka, L. (1996) Pharmacokinetics of phenazone (antipyrine) in rabbits with experimental common bile duct obstruction. British Journal of Pharmacology, 117, 1–4.
10.1111/j.1476-5381.1996.tb15146.x
CAS PubMed Web of Science® Google Scholar
Youssef, S. A., El-Gendi, A. Y. I., El-Sayed, M. G. A., Ateg, M. & Abdelsalam, S. A. (1981) Some pharmacokinetic and biochemical aspects of sulphadiazine and sulphadimidine in ewes. Journal of Veterinary Pharmacology and Therapeutics, 4, 173–182.
10.1111/j.1365-2885.1981.tb00728.x
CAS PubMed Google Scholar

Volume20, Issue3

June 1997

Pages 167-172

The effect of experimental fascioliasis on the pharmacokinetics of antipyrine and sulphadimidine in desert sheep

Abstract

References

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

The effect of experimental fascioliasis on the pharmacokinetics of antipyrine and sulphadimidine in desert sheep

Abstract

References

References

Related

Information