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DIPHENYLHYDANTOIN AS AN ANTICONVULSANT: PROTEIN BINDING AND FLUCTUATION OF THE SERUM AND CEREBROSPINAL FLUID LEVELS IN FORTY MENTALLY SUBNORMAL EPILEPTICS*
N. M. A. VIUKARI,
P. TAMMISTO,
N. M. A. VIUKARI
Research Department, Rinnekoti Institute for Mentally Retarded, Majalampi, and Department of Neurology, University of Helsinki, Finland
Search for more papers by this authorP. TAMMISTO
Research Department, Rinnekoti Institute for Mentally Retarded, Majalampi, and Department of Neurology, University of Helsinki, Finland
Search for more papers by this authorN. M. A. VIUKARI,
P. TAMMISTO,
N. M. A. VIUKARI
Research Department, Rinnekoti Institute for Mentally Retarded, Majalampi, and Department of Neurology, University of Helsinki, Finland
Search for more papers by this authorP. TAMMISTO
Research Department, Rinnekoti Institute for Mentally Retarded, Majalampi, and Department of Neurology, University of Helsinki, Finland
Search for more papers by this author*
This study has been supported by Rinnekoti Research Foundation.
REFERENCES
- Brodie, B. B. (1965) Displacement of one drug by another from carrier or receptor sites. Proc. ray. Soc. Med., 58, 946.
- Buchthal, F., Svensmark, O. and Schiller, P. J. (1960) Clinical and electroencephalographic correlations with serum levels of diphenylhydantoin. Arch. Neural. (Chic), 2, 624.
- Dili., W. A., Kazenko, A., Wolf, L. and Glazko, A. (1956) Studies on 5,5′-diphenylhydantoin (Dilantin) in animals and man. J. Pharmacol. exp. Ther., 118, 270.
-
Fkantzen, E.,
Hansen, J. M.,
Hansen, O. E. and
Kristensen, M. (1967) Phenytoin (Dilantin) intoxication.
Ada neural. scand., 43, 440.
10.1111/j.1600-0404.1967.tb05749.x Google Scholar
- Frey, H. H. and Kampmann, E. (1965) Tolerance to anticonvulsant drugs. Ada pharmacol. (Kbh.), 22, 159.
- Hansen, J. M. and Kristensen, M. (1965) Tolbutamide in the treatment of Parkinson's disease. A double blind trial. Dan. med. Bull., 12, 181.
- Husby, J. (1963) Delayed toxicity and serum concentrations of phenytoin. Dan. med. Bull., 10, 236.
- Jensen, B. N, and Grynderup, V. (1966) Studies on the metabolism of phenytoin. Epilepsia (Amst.) 7, 238.
- Kristensen, M., Hansen, J. M., Hansen, O. E. and Lund, V. (1967) Sources of error in the determination of phenytoin (Dilantin) by Svensmark & Kristensen's method. Atta neurol. scand., 43, 447.
- Kutt, H., Winters, W., Kokenge, R. and Mcdowell, F. (1964) Diphenylhydantoin metabolism, blood levels, and toxicity. Arch. Neurol. (Chic.), 11, 642.
- Kutt, H., Haynes, J. and Mcdowell, F. (1966) Some causes of ineffectiveness of diphenylhydantoin. Arch. Neural. (Chic), 14, 489.
- Levy, L. L. and Fenichel, G. M. (1965) Diphenylhydantoin activated seizures. Neurology (Minneap), 15, 716.
- Loeser, E. W. (1961) Studies on the metabolism of diphenylhydantoin (Dilantin). Neurology (Minneap), 11, 424.
- Porter, I. H. (1966) The genetics of drug susceptibility. Dis. nerv. Syst., 27, 25.
- Schreiner, G. E. (1958) The role of hemodialysis (artificial kidney) in acute poisoning. Arch. intern. Med., 102, 896.
- Stensrud, P. A. and Palmer, H. (1964) Serum phenytoin determinations in epileptics. Epilepsia (Amst), 5, 364.
- Svensmark, O. and Kristensen, P. (1963) Determination of diphenylhydantoin and pheno-barbital in small amounts of serum. J. Lab. clin. Med., 61, 501.
- Triedman, M. H., Fishman, R. A. and Yahr, M. D. (1960) Determination of plasma and cerebrospinal fluid levels of Dilantin in the human. Trans. Amer. neural. Ass., 85, 166.
- Tveten, L. (1963) Quantitative determinations of diphenylhydantoin in patients with epilepsy. T. norske Laegeforen., 83, 1785.
- Viukari, N. M. A. (1969) Diphenylhydantoin as an anticonvulsant: evaluation of treatment in forty mentally subnormal epileptics. J. ment. Defic. Res., 13, 212.
