SERUM CONCENTRATIONS OF GENTAMICIN IN PATIENTS WITH MYELOMENINGOCELE

Corresponding Author

M. C. Nahata

² College of Pharmacy, Ohio State University, 500 West 12th Avenue, Columbus, OH 43210, U.S.A.Search for more papers by this author

D. C. McComb,

D. C. McComb

Colleges of Pharmacy and Medicine, The Ohio State University; and Wexner Institute for Pediatric Research, Children's Hospital, Columbus, Ohio, U.S.A.

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P. R. Schad,

P. R. Schad

Colleges of Pharmacy and Medicine, The Ohio State University; and Wexner Institute for Pediatric Research, Children's Hospital, Columbus, Ohio, U.S.A.

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M. C. Nahata,

Corresponding Author

M. C. Nahata

² College of Pharmacy, Ohio State University, 500 West 12th Avenue, Columbus, OH 43210, U.S.A.Search for more papers by this author

D. C. McComb,

D. C. McComb

Colleges of Pharmacy and Medicine, The Ohio State University; and Wexner Institute for Pediatric Research, Children's Hospital, Columbus, Ohio, U.S.A.

Search for more papers by this author

P. R. Schad,

P. R. Schad

Colleges of Pharmacy and Medicine, The Ohio State University; and Wexner Institute for Pediatric Research, Children's Hospital, Columbus, Ohio, U.S.A.

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First published: August 1991

https://doi.org/10.1111/j.1365-2710.1991.tb00315.x

Citations: 1

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Summary

Gentamicin serum concentrations were studied in 18 paediatric and adult patients. The doses of gentamicin had to be adjusted for 6 of 18 patients to keep peak and trough serum concentrations below 8 and 2 (μg/ml, respectively. Thus, serum concentrations monitoring of gentamicin may be useful to individualize doses in patients with myelomeningocele. Additional studies are needed to define specific dosage guidelines in patients of varying ages and disease severity for optimal therapy.

References

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SERUM CONCENTRATIONS OF GENTAMICIN IN PATIENTS WITH MYELOMENINGOCELE

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