Journal of Clinical Pharmacy and Therapeutics

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SIMULTANEOUS HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF DAPSONE AND MONOACETYLDAPSONE IN HUMAN PLASMA AND URINE

Corresponding Author

M. A. Abuirjeie

¹ Department of Medicinal Chemistry, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, JordanSearch for more papers by this author

Y. M. Irshaid,

Y. M. Irshaid

*Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan

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H. F. A1-Hadidi,

H. F. A1-Hadidi

*Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan

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N. M. Rawashdeh,

N. M. Rawashdeh

*Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan

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M. A. Abuirjeie,

Corresponding Author

M. A. Abuirjeie

¹ Department of Medicinal Chemistry, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, JordanSearch for more papers by this author

Y. M. Irshaid,

Y. M. Irshaid

*Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan

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H. F. A1-Hadidi,

H. F. A1-Hadidi

*Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan

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N. M. Rawashdeh,

N. M. Rawashdeh

*Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan

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First published: August 1991

https://doi.org/10.1111/j.1365-2710.1991.tb00311.x

Citations: 5

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Summary

A rapid, specific and a one-stage protein precipitation method for simultaneous estimation of dapsone (DDS) and monoacetyldapsone (MAD) concentration in plasma and urine using high performance liquid chromatography (HPLC) is described. The applicability of the method for monitoring DDS and MAD blood levels in two different acetylator phenotype volunteers following the administration of 100-mg oral dose of DDS was shown. Cumulative urinary excretion of DDS and MAD were studied in the same volunteers.

References

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SIMULTANEOUS HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF DAPSONE AND MONOACETYLDAPSONE IN HUMAN PLASMA AND URINE

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SIMULTANEOUS HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF DAPSONE AND MONOACETYLDAPSONE IN HUMAN PLASMA AND URINE

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