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AN INVESTIGATION OF POLYMORPHISM IN THE INTERLEUKIN-10 GENE PROMOTER
Mr. D. M. Turner,
D. M. Williams,
D. Sankaran,
M. Lazarus,
P. J. Sinnott,
I. V. Hutchinson,
Corresponding Author
Mr. D. M. Turner
Tissue Typing, St Mary's Hospital, Stopford Building, University of Manchester, UK
Tissue Typing Laboratory, St Mary's Hospital, Hathersage Rd, Manchester M13 OJH, UK.Search for more papers by this authorD. M. Williams
School of Biological Sciences, Stopford Building, University of Manchester, UK
Search for more papers by this authorD. Sankaran
School of Biological Sciences, Stopford Building, University of Manchester, UK
Search for more papers by this authorM. Lazarus
School of Biological Sciences, Stopford Building, University of Manchester, UK
Search for more papers by this authorP. J. Sinnott
Tissue Typing, St Mary's Hospital, Stopford Building, University of Manchester, UK
Search for more papers by this authorI. V. Hutchinson
School of Biological Sciences, Stopford Building, University of Manchester, UK
Search for more papers by this authorMr. D. M. Turner,
D. M. Williams,
D. Sankaran,
M. Lazarus,
P. J. Sinnott,
I. V. Hutchinson,
Corresponding Author
Mr. D. M. Turner
Tissue Typing, St Mary's Hospital, Stopford Building, University of Manchester, UK
Tissue Typing Laboratory, St Mary's Hospital, Hathersage Rd, Manchester M13 OJH, UK.Search for more papers by this authorD. M. Williams
School of Biological Sciences, Stopford Building, University of Manchester, UK
Search for more papers by this authorD. Sankaran
School of Biological Sciences, Stopford Building, University of Manchester, UK
Search for more papers by this authorM. Lazarus
School of Biological Sciences, Stopford Building, University of Manchester, UK
Search for more papers by this authorP. J. Sinnott
Tissue Typing, St Mary's Hospital, Stopford Building, University of Manchester, UK
Search for more papers by this authorI. V. Hutchinson
School of Biological Sciences, Stopford Building, University of Manchester, UK
Search for more papers by this authorFirst published: 02 February 2011
Citations: 1,312
SUMMARY
Interleukin-10 (IL-10) has been described as an anti-inflammatory cytokine and B-cell proliferation factor and has been implicated in autoimmunity, tumorigenesis and transplantation tolerance. We have identified three single base pair substitutions in the IL-10 gene promoter and have investigated whether this polymorphism correlates with IL-10 protein production in vitro.
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