Volume 19, Issue 6 pp. 816-819

VEGF mRNA expression in jugulotympanic paraganglioma

X. ZHANG medical postgraduate ,

X. ZHANG medical postgraduate

Department of ENT, Anhui provincial Hospital, Anhui Medical University, Hefei, Anhui

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W. XU md ,

Corresponding Author

W. XU md

Department of ENT, Anhui provincial Hospital, Anhui Medical University, Hefei, Anhui

Dr. Weiqing Xu, Department of Otolaryngology Head and Neck Surgery, Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui Province Anhui Province 23001, China (e-mail: [email protected]). Search for more papers by this author

J. SUN md ,

J. SUN md

Department of ENT, Anhui provincial Hospital, Anhui Medical University, Hefei, Anhui

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K. ZHANG chief physician ,

K. ZHANG chief physician

Department of ENT, Hefei No.1 Hospital, Anhui Medical University, Hefei, Anhui, China

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X. ZHANG medical postgraduate ,

X. ZHANG medical postgraduate

Department of ENT, Anhui provincial Hospital, Anhui Medical University, Hefei, Anhui

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W. XU md ,

Corresponding Author

W. XU md

Department of ENT, Anhui provincial Hospital, Anhui Medical University, Hefei, Anhui

J. SUN md ,

J. SUN md

Department of ENT, Anhui provincial Hospital, Anhui Medical University, Hefei, Anhui

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K. ZHANG chief physician ,

K. ZHANG chief physician

Department of ENT, Hefei No.1 Hospital, Anhui Medical University, Hefei, Anhui, China

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First published: 17 December 2009

https://doi.org/10.1111/j.1365-2354.2009.01098.x

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Abstract

ZHANG X., XU W., SUN J. & ZHANG. K. (2010) European Journal of Cancer Care19, 816–819
VEGF mRNA expression in jugulotympanic paraganglioma

The vascular endothelial growth factor (VEGF) family are essential regulators of angiogenesis and vascular permeability. VEGF protein was found in the jugulotympanic paraganglioma, but it wasn't confirmed on mRNA level. Our aim of this study is the mRNA expression of VEGF in jugulotympanic paraganglioma. We chose six cases of primary jugulotympanic paraganglioma wax specimen by hybridisation in situ. It suggested that VEGF mRNA had significant expression in the tumour cytoplasm of jugulotympanic paraganglioma. The correlation is not yet clear. It could be suggested the higher degree of malignancy, the stronger expression of VEGF mRNA in cytoplasm, but not found in the cellular nucleus.

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VEGF mRNA expression in jugulotympanic paraganglioma

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