Chemometrics assisted investigation of variations in infrared spectra of blood samples obtained from women with breast cancer: a new approach for cancer diagnosis
Corresponding Author
M. KHANMOHAMMADI phd
Department of Chemistry, Faculty of Science, IKIU, Qazvin
Mohammadreza Khanmohammadi, Department of Chemistry, Faculty of Science, IKIU, Qazvin, PO Box 288, Iran (e-mail: [email protected]). Search for more papers by this authorF.H. RAJABI phd
Department of Chemistry, Faculty of Science, IKIU, Qazvin
Search for more papers by this authorA.B. GARMARUDI msc
Department of Chemistry, Faculty of Science, IKIU, Qazvin, Department of Chemistry & Polymer Laboratories, Engineering Research Institute, Tehran
Search for more papers by this authorR. MOHAMMADZADEH msc
Department of Chemistry, Faculty of Science, IKIU, Qazvin
Search for more papers by this authorR. MOHAMMADZADEH md
Cardiac Surgery and Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorCorresponding Author
M. KHANMOHAMMADI phd
Department of Chemistry, Faculty of Science, IKIU, Qazvin
Mohammadreza Khanmohammadi, Department of Chemistry, Faculty of Science, IKIU, Qazvin, PO Box 288, Iran (e-mail: [email protected]). Search for more papers by this authorF.H. RAJABI phd
Department of Chemistry, Faculty of Science, IKIU, Qazvin
Search for more papers by this authorA.B. GARMARUDI msc
Department of Chemistry, Faculty of Science, IKIU, Qazvin, Department of Chemistry & Polymer Laboratories, Engineering Research Institute, Tehran
Search for more papers by this authorR. MOHAMMADZADEH msc
Department of Chemistry, Faculty of Science, IKIU, Qazvin
Search for more papers by this authorR. MOHAMMADZADEH md
Cardiac Surgery and Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorAbstract
KHANMOHAMMADI M., RAJABI F.H., GARMARUDI A.B., MOHAMMADZADEH R. & MOHAMMADZADEH R. (2010) European Journal of Cancer Care19, 352–359Chemometrics assisted investigation of variations in infrared spectra of blood samples obtained from women with breast cancer: a new approach for cancer diagnosis
Fourier transform infrared spectra of blood samples obtained from healthy women and those affected by breast cancer have been analysed statistically. Several spectral differences were detected in the N–H stretching signals of amides I and II bands. The position of α-helix and β-sheet amide I bands would shift in cancerous blood samples during stage development. Investigating the absorbance bands in the Fourier transform infrared spectra during the different stages of cancer, many changes are clearly observed in the intensity of a single band or the absorbance ratio of signals, indicating the changes that would occur in blood ingredients during cancer stages. These observations imply that the information is useful for diagnostic study of breast cancer and malignant abnormalities by infrared spectroscopy of whole blood samples. Finally, linear discriminant analysis was applied for classification of cancer case and normal case blood samples. The accuracy of the proposed method was 97.9%.
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