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Erythrocytes of patients with paroxysmal nocturnal haemoglobinuria acquire resistance to complement attack by purified 20-kD homologous restriction factor
N. OKADA,
R. HARADA,
H. OKADA,
N. OKADA
Department of Microbiology, Fukuoka University School of Medicine, Nanakuma, Fukuoka
Search for more papers by this authorR. HARADA
Department of Microbiology, Fukuoka University School of Medicine, Nanakuma, Fukuoka
Search for more papers by this authorCorresponding Author
H. OKADA
Department of Molecular Biology, Nagoya City University School of Medicine, Nagoya, Japan
Dr Noriko Okada, Department of Microbiology, Fukuoka University School of Medicine, Nanakuma 7-45-1, Fukuoka 814-01, Japan.Search for more papers by this authorN. OKADA,
R. HARADA,
H. OKADA,
N. OKADA
Department of Microbiology, Fukuoka University School of Medicine, Nanakuma, Fukuoka
Search for more papers by this authorR. HARADA
Department of Microbiology, Fukuoka University School of Medicine, Nanakuma, Fukuoka
Search for more papers by this authorCorresponding Author
H. OKADA
Department of Molecular Biology, Nagoya City University School of Medicine, Nagoya, Japan
Dr Noriko Okada, Department of Microbiology, Fukuoka University School of Medicine, Nanakuma 7-45-1, Fukuoka 814-01, Japan.Search for more papers by this authorSUMMARY
A 20-kD homologous restriction factor (HRF20) which is a membrane inhibitor of the terminal stage of human complement action can be detected by the monoclonal antibody IF5, and is deficient on abnormal erythrocytes as well as leucocytes from patients with paroxysmal nocturnal haemoglobinuria (PNH). The erythrocytes of PNH patients significantly improved their resistance to homologous complement after adsorption of purified HRF20.
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