Absolute lymphocyte count predicts overall survival in follicular lymphomas
Kay Ristow
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorSvetomir N. Markovic
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorThomas E. Witzig
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorThomas M. Habermann
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorJoseph P. Colgan
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorDavid J. Inwards
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorWilliam L. White
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorStephen M. Ansell
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorIvana N. Micallef
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorPatrick B. Johnston
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorTimothy G. Call
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorLuis F. Porrata
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorKay Ristow
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorSvetomir N. Markovic
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorThomas E. Witzig
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorThomas M. Habermann
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorJoseph P. Colgan
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorDavid J. Inwards
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorWilliam L. White
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorStephen M. Ansell
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorIvana N. Micallef
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorPatrick B. Johnston
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorTimothy G. Call
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorLuis F. Porrata
Division of Hematology/Department Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorSummary
The peripheral blood absolute lymphocyte count (ALC) recovery after autologous stem cell transplantation has been shown to be an independent prognostic factor for survival for different haematologic malignancies. The role of ALC at diagnosis for follicular (grades 1 and 2) lymphomas (FL) on survival is not well described. The primary objective of this study was to assess the role of ALC on overall survival (OS) in FL patients. Of 1104 FL patients, 228 patients were originally diagnosed, followed, and had all treatment at the Mayo Clinic from 1984 and 1999, were evaluated. The median follow-up was 89 months (range: 8·35–248). ALC as a continuous variable was identified as a predictor for OS [Hazard ratio (HR) = 0·74, P < 0·04]. ALC ≥ 1·0 × 109/l (n = 164) predicted a longer OS versus ALC < 1·0 × 109/l (n = 64; 175 vs. 73 months respectively, P < 0·0001). When compared with the Follicular Lymphoma International Prognostic Index (FLIPI), ALC was an independent prognostic factor for OS by multivariate analysis (HR = 0·677, P < 0·0001). These data suggest a critical role of FL patients’ immune status at diagnosis on survival.
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