DERMATOPATHOLOGY
p75 Neurotrophin receptor differentiates between morphoeic basal cell carcinoma and desmoplastic trichoepithelioma: insights into the histogenesis of adnexal tumours based on embryology and hair follicle biology
D. Krahl, K. Sellheyer,
K. Sellheyer
Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, U.S.A.
Nelson Dermatopathology Associates, 5755 Dupree Dr NW, Atlanta, GA 30327, U.S.A.
Search for more papers by this authorD. Krahl, K. Sellheyer,
K. Sellheyer
Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, U.S.A.
Nelson Dermatopathology Associates, 5755 Dupree Dr NW, Atlanta, GA 30327, U.S.A.
Search for more papers by this authorKlaus Sellheyer.E-mail: [email protected]
Conflicts of interestNone declared.
Summary
Background Tumour development is frequently described in the basic pathology literature as a recapitulation of embryogenesis. However, a link between the embryology of the skin and the histogenesis of adnexal tumours has been largely overlooked. The low-affinity p75 neurotrophin receptor (p75NTR) has a profound role in hair follicle biology. We therefore speculated that it is involved in the histogenesis of follicular adnexal tumours. One of the most challenging diagnoses in dermatopathology is differentiating morphoeic basal cell carcinoma from desmoplastic trichoepithelioma.
Objectives To describe the expression pattern of p75NTR during cutaneous embryogenesis, in the adult hair follicle and in morphoeic basal cell carcinoma and desmoplastic trichoepithelioma.
Methods Evaluation of the staining pattern for p75NTR was performed using standard immunohistochemical techniques. For comparison, we examined staining for cytokeratin 20 which highlights Merkel cells.
Results All 17 desmoplastic trichoepitheliomas were immunoreactive with > 80% of the cells stained, whereas 12 of the 14 (86%) morphoeic basal cell carcinomas were p75NTR negative. In the two positive cases of morphoeic basal cell carcinoma < 30% of cells were labelled. In the late bulbous hair peg stage and in the postnatal anagen hair follicle p75NTR highlights the outer root sheath.
Conclusions Our results support the classification of desmoplastic trichoepithelioma as a follicular hamartoma mimicking the outer root sheath. In contrast, the lack of p75NTR expression in morphoeic basal cell carcinoma favours a concept of this tumour as a more primitive follicular lesion with the characteristics of a carcinoma and not a hamartoma. We suggest including p75NTR as a tool in the differential diagnosis between morphoeic basal cell carcinoma and desmoplastic trichoepithelioma.
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