Molecular aetiology and pathogenesis of basal cell carcinoma
C.M.L.J. Tilli,
M.A.M. Van Steensel,
G.A.M. Krekels,
H.A.M. Neumann,
F.C.S. Ramaekers,
C.M.L.J. Tilli
Research Institute of Growth & Development (GROW)
Dermatology
Molecular Cell Biology, University of Maastricht, The Netherlands
Search for more papers by this authorM.A.M. Van Steensel
Research Institute of Growth & Development (GROW)
Dermatology
Search for more papers by this authorG.A.M. Krekels
Research Institute of Growth & Development (GROW)
Dermatology
Search for more papers by this authorH.A.M. Neumann
Research Institute of Growth & Development (GROW)
Department of Dermatology & Venereology, Erasmus University Rotterdam, The Netherlands
Search for more papers by this authorF.C.S. Ramaekers
Research Institute of Growth & Development (GROW)
Molecular Cell Biology, University of Maastricht, The Netherlands
Search for more papers by this authorC.M.L.J. Tilli,
M.A.M. Van Steensel,
G.A.M. Krekels,
H.A.M. Neumann,
F.C.S. Ramaekers,
C.M.L.J. Tilli
Research Institute of Growth & Development (GROW)
Dermatology
Molecular Cell Biology, University of Maastricht, The Netherlands
Search for more papers by this authorM.A.M. Van Steensel
Research Institute of Growth & Development (GROW)
Dermatology
Search for more papers by this authorG.A.M. Krekels
Research Institute of Growth & Development (GROW)
Dermatology
Search for more papers by this authorH.A.M. Neumann
Research Institute of Growth & Development (GROW)
Department of Dermatology & Venereology, Erasmus University Rotterdam, The Netherlands
Search for more papers by this authorF.C.S. Ramaekers
Research Institute of Growth & Development (GROW)
Molecular Cell Biology, University of Maastricht, The Netherlands
Search for more papers by this authorFCS Ramaekers.
E-mail: [email protected]
Conflicts of interest: None declared.
Summary
Recent insights into the cell biology of the epidermis and its appendages are transforming our understanding of the pathogenesis of basal cell carcinoma (BCC). The significant progress that has been made warrants a comprehensive review of the molecular and cellular pathology of BCC. The items addressed include environmental and genetic risk factors, the biology of the putative precursor cell(s), and the contribution of aberrations in processes such as apoptosis, cell proliferation, differentiation and signalling to carcinogenesis. Furthermore, established and novel treatment modalities are discussed with particular attention to future biological approaches.
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