In vivo effects of interferon-γ and anti-interferon-γ antibody on the experimentally induced lichenoid tissue reaction
Corresponding Author
T. SHIOHARA
Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan
Tetsuo Shiohara, Department of Dermatology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, Japan.Search for more papers by this authorB. J. NICKOLOFF
Departments of Pathology and Dermatology, University of Michigan Medical Center, Ann Arbor, U.S.A.
Search for more papers by this authorN. MORIYA
Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan
Search for more papers by this authorC. GOTOH
Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan
Search for more papers by this authorM. NAGASHIMA
Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan
Search for more papers by this authorCorresponding Author
T. SHIOHARA
Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan
Tetsuo Shiohara, Department of Dermatology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, Japan.Search for more papers by this authorB. J. NICKOLOFF
Departments of Pathology and Dermatology, University of Michigan Medical Center, Ann Arbor, U.S.A.
Search for more papers by this authorN. MORIYA
Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan
Search for more papers by this authorC. GOTOH
Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan
Search for more papers by this authorM. NAGASHIMA
Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan
Search for more papers by this authorSUMMARY
We investigated the in vivo effect of recombinant interferon-γ (IFN-γ) and tumour necrosis factor α (TNF-α) treatment of mice on the development of the delayed-type hypersensitivity (DTH) reaction and lichenoid tissue reaction (LTR) following the local injection of cloned autoreactive T cells. Both the DTH reaction and the LTR were significantly enhanced by pre-treatment with IFN-γ, but not with TNF-ã. Induction of class II MHC antigens on keratinocytes was not essential for the enhancement by IFN-γ. Administration of anti-IFN-γ antibody reduced the DTH reaction and LTR, although complete inhibition was not observed with our treatment regimen. The ability of IFN-γ to increase the number of the cloned T cells invading the epidermis in vivo, is in keeping with our previous observation that IFN-γ treatment of cultured keratinocytes markedly increased the adherence reaction between T cells and keratinocytes in vitro.
REFERENCES
- 1 Trinchieri G, Perussia B. Immune interferon: a pleiotropic lymphokine with multiple effects. Immunol Today 1985; 6: 131–6.
- 2 Basham TY, Nickoloff BJ, Merigan TC, Morhenn VB. Recombinant gamma interferon induces HLA-DR expression on cultured human keratinocytes. J Invest Dermatol 1984; 83: 88–91.
- 3 Metzer SJ, Faller DV, Burakoff SJ. Interferon-γ induction of LFA-I-mediated homotypic adhesion of human monocytes. J Immunol 1986; 137: 108–13.
- 4 Schulz RM, Kleinschmidt WJ. Functional identity between murine recombinant gamma interferon (IFN-γ) and macrophage activating factor. Nature 1983; 305: 239–40.
- 5 Shalaby MR, Aggarwal BB, Rinderknecht E et al. Activation of human polymorphonuclear neutrophil functions by interferon-γ and tumor necrosis factors. J Immunol 1985; 135: 2060–73.
- 6 Londei M, Bottazzo GF, Feldmann M. Human T-cell clones from autoimmune thyroid glands: specific recognition of autologous thyroid cells. Science 1985; 228: 85–9.
- 7 Rosenberg YJ, Steinberg AD, Santoro TJ. The basis of autoimmunity in MRL-lpr/lpr mice: a role for self Iareactive T cells. Immunol Today 1984; 5: 64–7.
- 8 Shiohara T, Moriya N, Mochizuki T, Nagashima M. Lichenoid tissue reaction (LTR) induced by local transfer ofIa-reactive T cell clones. II. LTR by epidermal invasion of cytotoxic lymphokine-producing autoreactive T cells. J Invest Dermatol 1987; 89: 8–14.
- 9 Shiohara T, Ruddle NH, Horowitz M et al. Anti-tumor activity of class II MHC antigen-restricted cloned autoreactive T cells. I. Destruction of B16 melanoma cells mediated by bystander cytolysis in vitro J Immunol 1987; 138: 1971–8.
- 10 Shiohara T, Moellmann G, Jacobson K et al. Anti-tumor activity of class II MHC antigen-restricted cloned autoreactive T cells. II. Novel immunotherapy of B16 melanomas by local and systemic adoptive transfer. J Immunol 1987; 138: 1979–86.
- 11 Nickoloff BJ, Lewinsohn DM, Butcher EC. Enhanced binding of peripheral blood mononuclear leukocytes to γ interferon-treated cultured keratinocytes. Am J Dermatopathol 1987; 9: 413–8.
- 12 Roberts LK, Spangrude GJ, Daynes RA et al. Correlation between keratinocyte expression of Ia and the intensity and duration of contact hypersensitivity responses in mice. J Immunol 1985; 135: 2929–36.
- 13 Nickoloff BJ, Basham TY, Merigan TC et al. Keratinocyte class II histocompatibility antigen expression. Br J Dermatol 1985; 112: 373.
- 14 Morhenn VB. The etiology of lichen planus. A hypothesis. Am J Dcrmatapathol 1986; 8: 154–6.
- 15 Gaspari AA, Katz SI. Induction and functional characterization of class II antigens on murine keratinocytes. J Invest Dermatol 1987; 88: 490 (abstract).
- 16 Tsujimoto M, Yip YM, Viocek J. Interferon-γ enhances expression of cellular receptors for tumor necrosis factor. J Immunol 1986; 136: 2442–4.
- 17 Arenzana-seisdedos F, Virelizeir JL, Fiers W. Interferons as macrophage-activating factors. III. Preferential effects of interferon-γ on the interleukin I secretory potential of fresh or aged human monocytes. J Immunol 1985; 134: 2444–8.
- 18 Sauder DN, Monick MM, Hunninghake GW. Epidermal cell-derived thymocyte activating factor (ETAF) is a potent T-cell chemoattractant. J Invest Dermatol 1985; 85: 431–3.
- 19 Nickoloff BJ, Lewinsohn DM, Butcher EC et al. Recombinant gamma interferon increases the binding of peripheral blood mononuclear leukocytes and a Leu-3+ T lymphocyte cell clone to cultured keratinocytes and a malignant cutaneous squamous carcinoma celt line which is blocked by antibody against the LFA-I molecule. J Invest Dermatol 1988; 90: 17–22.
- 20 Old LJ. Tumor necrosis factor (TNF). Science 1985; 230: 630–2.
- 21 Dustin ML, Rothlein R, Bhan AK et al. Induction by IL I and interferon: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-l). J Immunol 1986; 137: 1270–4.
- 22 Lee SH, Aggarwal BB, Rinderknecht E et at. The synergistic anti-proliferative effect of y-interferon and human lymphotoxin. J Immunol 1984; 133: 1083–6.
- 23 Tite JP, Powell MB, Ruddle NH. Protein-antigen specific la-restricted cytolytic T cells; analysis of frequency, target cell susceptibility, and mechanism of cytolysis. J Immunol 1985; 135: 24–33.
- 24 Ruddle NH. Tumor necrosis factor and related cytotoxins. Immunol Today 1987; 8: 129–30.
- 25 Wofsy D, Seaman WE. Reversal of advanced murine lupus in NZB/NZW F1 mice by treatment with monoclonal antibody to L3T4. J Immunol 1987; 138: 3247–53.
