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Hypersensitivity of scleroderma cutaneous vascular smooth muscle to 5-hydroxytryptamine
R.K. WINKELMANN,
MARC E. GOLDYNEAND,
RONALD L. LINSCHEID,
Corresponding Author
R.K. WINKELMANN
Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901, U.S.A.
Reprint requests to Dr Winkelmann, Mayo Clinic, Rochester, Minnesota 55901, U.S.A.Search for more papers by this authorMARC E. GOLDYNEAND
Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901, U.S.A.
Search for more papers by this authorRONALD L. LINSCHEID
Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901, U.S.A.
Search for more papers by this authorR.K. WINKELMANN,
MARC E. GOLDYNEAND,
RONALD L. LINSCHEID,
Corresponding Author
R.K. WINKELMANN
Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901, U.S.A.
Reprint requests to Dr Winkelmann, Mayo Clinic, Rochester, Minnesota 55901, U.S.A.Search for more papers by this authorMARC E. GOLDYNEAND
Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901, U.S.A.
Search for more papers by this authorRONALD L. LINSCHEID
Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901, U.S.A.
Search for more papers by this authorSUMMARY
Vascular smooth muscle strips from subcutaneous wrist vessels of patients with scleroderma (systemic sclerosis) were studied in an isolated system. No difference between catecholamine response of scleroderma or control vessel strips was observed. Three of four patients demonstrated significant hypersensitivity to 5-hydroxytryptamine as compared to control values. Serotonin hypersensitivity may play a role in the evolution of Raynaud's phenomenon and vascular scleroderma.
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