First-trimester fetal heart rate in mothers with opioid addiction

Corresponding Author

Maximilian Schmid

Department of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Austria and

Maximilian Schmid, Department of Obstetrics and Feto-maternal Medicine, Medical University of Vienna General Hospital, Waehringer Guertel 18-20, A-1090 Vienna, Austria. E-mail: [email protected]Search for more papers by this author

Lorenz Kuessel,

Lorenz Kuessel

Department of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Austria and

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Katharina Klein,

Katharina Klein

Department of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Austria and

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Verena Metz,

Verena Metz

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria

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Gabriele Fischer,

Gabriele Fischer

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria

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Elisabeth Krampl-Bettelheim,

Elisabeth Krampl-Bettelheim

Department of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Austria and

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Maximilian Schmid,

Corresponding Author

Maximilian Schmid

Department of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Austria and

Lorenz Kuessel,

Lorenz Kuessel

Department of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Austria and

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Katharina Klein,

Katharina Klein

Department of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Austria and

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Verena Metz,

Verena Metz

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria

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Gabriele Fischer,

Gabriele Fischer

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria

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Elisabeth Krampl-Bettelheim,

Elisabeth Krampl-Bettelheim

Department of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Austria and

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First published: 08 June 2010

https://doi.org/10.1111/j.1360-0443.2010.02982.x

Citations: 26

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ABSTRACT

Aim To investigate the difference in fetal heart rate of opioid-dependent mothers compared to non-dependent mothers in the first trimester of pregnancy.

Design The data of 74 consecutive singleton pregnancies of mothers enrolled in a maintenance programme for opioid-dependent women was matched to 74 non-exposed singleton pregnancies by maternal age, crown–rump length, smoking status, ethnic background and mode of conception.

Measurement Fetal heart rate measured as part of first-trimester screening by Doppler ultrasound between 11+0 and 13+6 gestational weeks was compared retrospectively.

Findings The mean fetal heart rate in opioid-dependent mothers was 156.0 beats per minute (standard deviation 7.3) compared to 159.6 (6.5) in controls. The difference in fetal heart rate was significant (P = 0.02). There was a significant difference in mean maternal body mass index (P = 0.01) but not in mean nuchal translucency (P = 0.3), gestational age (0.5), fetal gender (P = 0.3) and parity (P = 0.3) between both groups. Fifty-five per cent (41 of 74) of cases were taking methadone, 30% (22 of 74) buprenorphine and 15% (11 of 74) were taking slow-release morphines throughout the pregnancy.

Conclusions In fetuses of opioid-dependent mothers a decreased fetal heart rate can already be observed between 11+0 and 13+6 gestational weeks. The effect of opioid intake needs to be taken into consideration when interpreting fetal heart rate in opioid-dependent mothers at first-trimester screening.

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Volume105, Issue7

July 2010

Pages 1265-1268

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First-trimester fetal heart rate in mothers with opioid addiction

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