Combined Effects of Differentiation-inducing Factor and Other Cytokines on Induction of Differentiation of Mouse Myeloid Leukemic Cells
Yuri Yamamoto-Yamaguchi
Department of Chemotherapy, Saitama Cancer Center Research Institute, Ina-machi, Kita-adachi-gun, Saitama-ken 362, Japan
Search for more papers by this authorMikio Tomida
Department of Chemotherapy, Saitama Cancer Center Research Institute, Ina-machi, Kita-adachi-gun, Saitama-ken 362, Japan
Search for more papers by this authorMotoo Hozumi
Department of Chemotherapy, Saitama Cancer Center Research Institute, Ina-machi, Kita-adachi-gun, Saitama-ken 362, Japan
Search for more papers by this authorHans Rainer Maurer
Institute für Pharmazie der Freien Universität Berlin, Königin-Luise-Straβe 2±4, D-1000, Berlin 33, Federal Republic of Germany
Search for more papers by this authorTetsuro Okabe
The Third Department of Internal Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan
Search for more papers by this authorFumimaro Takaku
The Third Department of Internal Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan
Search for more papers by this authorYuri Yamamoto-Yamaguchi
Department of Chemotherapy, Saitama Cancer Center Research Institute, Ina-machi, Kita-adachi-gun, Saitama-ken 362, Japan
Search for more papers by this authorMikio Tomida
Department of Chemotherapy, Saitama Cancer Center Research Institute, Ina-machi, Kita-adachi-gun, Saitama-ken 362, Japan
Search for more papers by this authorMotoo Hozumi
Department of Chemotherapy, Saitama Cancer Center Research Institute, Ina-machi, Kita-adachi-gun, Saitama-ken 362, Japan
Search for more papers by this authorHans Rainer Maurer
Institute für Pharmazie der Freien Universität Berlin, Königin-Luise-Straβe 2±4, D-1000, Berlin 33, Federal Republic of Germany
Search for more papers by this authorTetsuro Okabe
The Third Department of Internal Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan
Search for more papers by this authorFumimaro Takaku
The Third Department of Internal Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan
Search for more papers by this authorA recipient of a Guest Foreign Research Fellowship of the Foundation for Promotion of Cancer Research of Japan. 4 Abbreviations used are: D-factor, differentiation-inducing factor; G-CSF, granulocyte colony-stimulating factor; rG-CSF, recombinant granulocyte colony-stimulating factor; TNF, tumor necrosis factor; rTNF, recombinant tumor necrosis factor; IL-1, interleukin 1; rIL-1, recombinant interleukin 1; LT, lymphotoxin; rLT, recombinant lymphotoxin.
Abstract
Mouse myeloid leukemic M1 cells are induced to differentiate into macrophage-like cells by differentiation-inducing factors (D-factors) and granulocyte colony-stimulating factor. We examined the effects of recombinant human tumor necrosis factor (rTNF), lymphotoxin (rLT) and interleukin 1 (rIL-1) on the induction of differentiation of M1 cells, compared with the effects of D-factor purified from the conditioned medium of mouse Ehrlich as cites tumor cells and recombinant human granulocyte colony-stimulating factor (rG-CSF). rIL-1 induced phagocytic activity, a typical marker of cell differentiation, in at most 30% of M1 cells at concentrations ranging from 10-10M to 10-7M. The differentiation-inducing activity of rIL-1 was similar to that of rG-CSF and less than that of D-factor. rTNF induced phagocytic activity in 14% of M1 cells only at a high concentration (10-7M). rLT did not induce differentiation of the cells even at 10-7M. rTNF stimulated induction of differentiation of M1 cells by D-factor, rG-CSF or rIL-1 by two or three fold. The combination of any two of the cytokines D-factor, rG-CSF and rIL-1 induced differentiation of M1 cells more efficiently than any of these cytokines alone. Moreover, the combination of three cytokines rG-CSF, rIL-1 and rTNF, all of which are known to be produced by macrophages, was more effective than the combination of any two of these cytokines in induction of differentiation of M1 cells.
REFERENCES
- 1 ) Ichikawa , Y. Further studies on the differentiation of a cell line of myeloid leukemia . J. Cell. Physiol. , 76 , 175 – 184 ( 1970 ).
- 2 ) Hozumi , M. Fundamentals of chemotherapy of myeloid leukemia by induction of leukemia cell differentiation . Adv. Cancer Res. , 38 , 121 – 169 ( 1983 ).
- 3 ) Tomida , M. , Yamamoto-Yamaguchi , Y. and Hozumi , M. Purification of a factor inducing differentiation of mouse myeloid leukemic M1 cells from conditioned medium of mouse flbroblast L929 cells . J. Biol. Chem. , 259 , 10978 – 10982 ( 1984 ).
- 4 ) Tomida , M. , Yamamoto-Yamaguchi , Y. and Hozumi , M. Characterization of a factor inducing differentiation of mouse myeloid leukemic cells purified from conditioned medium of mouse Ehrlich ascites tumor cells . FEBS Lett. , 178 , 291 – 296 ( 1984 ).
- 5 ) Tomida , M. , Yamamoto-Yamaguchi , Y. and Hozumi , M. Preparation and neutralization characteristics of an antibody to the factor inducing differentiation of mouse myeloid leukemic cells . FEBS Lett. , 151 , 281 – 285 ( 1983 ).
- 6 ) Tomida , M. Regulation of differentiation of normal and leukemic precursors of macrophages . In “ Mononuclear Phagocytes: Physiology and Pathology ,” ed. R. T. Dean and W. Jessup , pp. 243 – 264 ( 1985 ). Elsevier , Amsterdam , New York .
- 7 ) Gearing , D. P. , Gough , N. M. , King , J. A. , Hilton , D. J. , Nicola , N. A. , Simpson , R. J. , Nice , E. C. , Kelso , A. and Metcalf , D. Molecular cloning and expression of cDNA encoding a murine myeloid leukemia inhibitory factor (LIF) . EMBO J. , 6 , 3995 – 4002 ( 1987 ).
- 8 ) Olsson , I. L. , Sarngadharan , M. G. , Breitman , T. R. and Gallo , R. C. Isolation and characterization of a T lymphocyte-derived differentiation inducing factor for the myeloid leukemic cell line HL-60 . Blood , 63 , 510 – 517 ( 1984 ).
- 9 ) Leung , K. and Chiao , J. W. Human leukemia cell maturation induced by a T-cell lymphokine isolated from medium conditioned by normal lymphocytes . Proc. Natl. Acad. Sci. USA , 82 , 1209 – 1213 ( 1985 ).
- 10 ) Trinchieri , G. , Kobayashi , M. , Rosen , M. , Loudon , R. , Murphy , M. and Perussia , B. Tumor necrosis factor and lymphotoxin induce differentiation of human myeloid cell lines in synergy with immune interferon . J. Exp. Med. , 164 , 1206 – 1225 ( 1986 ).
- 11 ) Takeda , K. , Iwamoto , S. , Sugimoto , H. , Takuma , T. , Kawatani , N. , Noda , M. , Masaki , A. , Morise , H. , Arimura , H. and Konno , K. Identity of differentiation inducing factor and tumor necrosis factor . Nature , 323 , 338 – 340 ( 1986 ).
- 12 ) Hemmi , H. , Nakamura , T. , Tamura , K. , Shimizu , Y. , Kato , S. , Miki , T. , Takahashi , N. , Muramatsu , M. , Numao , N. and Sugamura , K. Lymphotoxin: induction of terminal differentiation of the human myeloid leukemia cell lines HL-60 and THP-1 . J. Immunol. , 138 , 664 – 666 ( 1987 ).
- 13 ) Gullberg , U. , Lantz , M. , Nilsson , E. , Peetre , C. , Adolf , G. and Olsson , I. Characterization of a relationship between the T-lymphocyte derived differentiation inducing factor (DIP) and lymphotoxin: a common receptor system for DIP, lymphotoxin and tumor necrosis factor downregulated by phorbol diesters . Eur. J. Haematol. , 39 , 241 – 251 ( 1987 ).
- 14 ) Ralph , P. , Harris , P. E , Punjabi , C. J. , Welter , K. , Litcofsky , P. B. , Ho , M-K. , Rubin , B. Y. , Moore , M. A. S. and Springer , T. A. Lymphokine inducing “terminal differentiation” of the human monoblast leukemia line U937: a role for γ-interferon . Blood , 62 , 1169 – 1175 ( 1983 ).
- 15 ) Ball , E. D. , Guy re , P. M. , Shen , L. , Glynn , J. M. , Maliszewski , C. R. , Baker , P. E. and Fanger , M. W. Gamma interferon induces monocytoid differentiation in the HL-60 cell line . J. Clin. Invest. , 73 , 1072 – 1077 ( 1984 ).
- 16 ) Nicola , N. A. , Metcalf , D. , Matsumoto , M. and Johnson , G. R. Purification of a factor inducing differentiation in murine myelomonocytic leukemia cells. Identification as granulocyte colony-stimulating factor . J. Biol. Chem. , 258 , 9017 – 9023 ( 1983 ).
- 17 ) Souza , L. M. , Boone , T. C. , Gabrilove , J. , Lai , P. H. , Zsebo , K. M. , Murdock , D. C. , Chazin , V. R. , Bruszewski , J. , Lu , H. , Chen , K. K. , Barendt , J. , Platzer , E. , Moore , M. A. S. , Mertelsmann , R. and Welte , K. Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells . Science , 232 , 61 – 65 ( 1986 ).
- 18 ) Tomida , M. , Yamamoto-Yamaguchi , Y. , Hozumi , M. , Okabe , T. and Takaku , F. Induction by recombinant human granulocyte colony-stimulating factor of differentiation of mouse myeloid leukemic M1 cells . FEBS Lett. , 207 , 271 – 275 ( 1986 ).
- 19 ) Tamatani , T. , Urawa , H. , Hashimoto , T. , and Onozaki , K. Tumor necrosis factor as an interleukin 1-dependent differentiation inducing factor (D-factor) for mouse myeloid leukemic cells . Biochem. Biophys. Res. Commun. , 143 , 390 – 397 ( 1987 ).
- 20 ) Bachwich , P. R. , Bhensue , S. W. , Larrick , J. W. and Kunkel , S. L. Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages . Biochem. Biophys. Res. Commun. , 136 , 94 – 101 ( 1986 ).
- 21 ) Browning , J. L. and Ribolini , A. Interferon blocks interleukin 1-induced prostaglandin release from human peripheral monocytes . J. Immunol. , 138 , 2857 – 2863 ( 1987 ).
- 22 ) Honma , Y. , Kasukabe , T. and Hozumi , M. Inhibition of differentiation of cultured mouse myeloid leukemia cells by nonsteroidal antiinflammatory agents and counteraction of the inhibition by prostaglandin E . Cancer Res. , 39 , 2190 – 2194 ( 1979 ).
- 23 ) Metcalf , D. and Nicola , N. A. Synthesis by mouse peritoneal cells of G-CSF, the differentiation inducer for myeloid leukemia cells: stimulation by endotoxin, M-CSF and Multi-CSF . Leuk. Res. , 9 , 35 – 50 ( 1985 ).
- 24 ) Nathan , C. F. Secretory products of macrophages . J. Clin. Inv. , 19 , 319 – 326 ( 1987 ).
- 25 ) Trinchieri , G. , Rosen , M. and Perussia , B. Retinoic acid cooperates with tumor necrosis factor and immune inter-feron in inducing differentiation and growth inhibition of the human promyelocytic leukemic cell line HL-60 . Blood , 69 , 1218 – 1224 ( 1987 ).
- 26 ) Trinchieri , G. , Rosen , M. and Perussia , B. Induction of differentiation of human myeloid cell lines by tumor necrosis factor in cooperation with 1a, 25-dihydroxyvitamin D3 . Cancer Res. , 47 , 2236 – 2242 ( 1987 ).
- 27 ) Onozaki , K. , Tamatani , T. , Hashimoto , T. and Matsushima , K. Growth inhibition and augmentation of mouse myeloid leukemic cell line differentiation by interleukin 1 . Cancer Res. , 47 , 2397 – 2402 ( 1987 ).
- 28 ) Miyaura , C. , Onozaki , K. , Akiyama , Y. , Taniyama , T. , Hirano , Kishimoto , T. and Suda , T. Recombinant human interleukin-6 (B-cell stimulatory factor 2) is a potent inducer of differentiation of mouse myeloid leukemia cells (M1) . FEBS Lett. , 234 , 17 – 21 ( 1988 ).
