Assessment of cardiovascular risk in an Italian psychiatric outpatient sample: A chart review of patients treated with second-generation antipsychotics
Elena Severi MD
Department of Mental Health and Drug Abuse, Azienda Unità Sanitaria Locale Modena, Modena, Italy
Search for more papers by this authorMaria Ferrara MD
Department of Mental Health and Drug Abuse, Azienda Unità Sanitaria Locale Modena, Modena, Italy
Search for more papers by this authorEnrico Tedeschini MD
Department of Mental Health and Drug Abuse, Azienda Unità Sanitaria Locale Modena, Modena, Italy
Search for more papers by this authorFrancesca Vacca MD
Department of Mental Health and Drug Abuse, Azienda Unità Sanitaria Locale Modena, Modena, Italy
Search for more papers by this authorCorresponding Author
Francesco Mungai MD
Department of Mental Health and Drug Abuse, Azienda Unità Sanitaria Locale Modena, Modena, Italy
Correspondence: Francesco Mungai, Department of Mental Health and Drug Abuse, AUSL Modena, Viale Muratori 201 Modena 41124, Italy. Email: [email protected]Search for more papers by this authorRocco Amendolara MD
Department of Mental Health and Drug Abuse, Azienda Unità Sanitaria Locale Modena, Modena, Italy
Search for more papers by this authorFlavia Baccari MD
Department of Mental Health and Drug Abuse, Azienda Unità Sanitaria Locale Modena, Modena, Italy
Search for more papers by this authorFabrizio Starace MD, MPh
Department of Mental Health and Drug Abuse, Azienda Unità Sanitaria Locale Modena, Modena, Italy
Search for more papers by this authorElena Severi MD
Department of Mental Health and Drug Abuse, Azienda Unità Sanitaria Locale Modena, Modena, Italy
Search for more papers by this authorMaria Ferrara MD
Department of Mental Health and Drug Abuse, Azienda Unità Sanitaria Locale Modena, Modena, Italy
Search for more papers by this authorEnrico Tedeschini MD
Department of Mental Health and Drug Abuse, Azienda Unità Sanitaria Locale Modena, Modena, Italy
Search for more papers by this authorFrancesca Vacca MD
Department of Mental Health and Drug Abuse, Azienda Unità Sanitaria Locale Modena, Modena, Italy
Search for more papers by this authorCorresponding Author
Francesco Mungai MD
Department of Mental Health and Drug Abuse, Azienda Unità Sanitaria Locale Modena, Modena, Italy
Correspondence: Francesco Mungai, Department of Mental Health and Drug Abuse, AUSL Modena, Viale Muratori 201 Modena 41124, Italy. Email: [email protected]Search for more papers by this authorRocco Amendolara MD
Department of Mental Health and Drug Abuse, Azienda Unità Sanitaria Locale Modena, Modena, Italy
Search for more papers by this authorFlavia Baccari MD
Department of Mental Health and Drug Abuse, Azienda Unità Sanitaria Locale Modena, Modena, Italy
Search for more papers by this authorFabrizio Starace MD, MPh
Department of Mental Health and Drug Abuse, Azienda Unità Sanitaria Locale Modena, Modena, Italy
Search for more papers by this authorAbstract
Despite the call by the scientific community for a systematic monitoring of physical health in people with psychiatric illnesses, national and international audits have reported poor quality of cardiovascular risk assessments and management in this vulnerable population. Available evidence indicates that in people affected by mental illness, life expectancy is reduced by 10–20 years, mainly due to cardiovascular accidents and metabolic syndrome (MetS)-related diseases. The primary aim of the present study was to evaluate the accuracy of cardiovascular risk monitoring in an outpatient sample of patients taking second-generation antipsychotics. The sample consisted of 200 patients consecutively recruited from two community mental health centres. A clinical chart review was performed on the following laboratory tests: total cholesterol, high- and low-density lipoprotein, serum triglycerides, fasting blood glucose, γ-glutamyl transpeptidase. Blood pressure and waist circumference were measured. A complete cardiovascular risk assessment was available only in 60 patients out of 200 (33.3%). The only variable associated with laboratory tests for MetS was receiving three or more psychotropic medications, which increased fourfold the probability of metabolic screening. In the subsample of patients with full screening, the prevalence of MetS was 33.3%. Our findings suggest that mental health professionals working in community mental health services should incorporate a more systematic assessment of physical health in their practice, and intervene proactively to reduce the significant cardiovascular burden carried by people with several mental illness.
References
- Alberti, K. G. (2006). Metabolic syndrome – a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabetic Medicine, 23, 469–480.
- Brunero, S., Lamont, S., & Fairbrother, G. (2009). Prevalence and predictors of metabolic syndrome among patients attending an outpatient clozapine clinic in Australia. Archives of Psychiatric Nursing, 23, 261–268.
- Casula, M., Poli, A., Tragni, E. et al. (2009). Prevalence of metabolic syndrome in Italy: The Check Study. Nutrition, Metabolism and Cardiovascular Diseases, 19, s5–s6.
- Cohn, T. A. & Sernyak, M. J. (2006). Metabolic monitoring for patients treated with antipsychotic medications. Canadian Journal of Psychiatry, 51, 492–501.
- Crabb, J., McAllister, M. & Blair, A. (2009). Who should swing the stethoscope? An audit of baseline physical examination and blood monitoring on new patients accepted by an early intervention in psychosis team. Early Intervention in Psychiatry, 3, 312–316.
- Cuerda, C., Velasco, C., Merchàn-Naranjo, J., Garcìa-Peris, P. & Arango, C. (2014). The effects of second-generation antipsychotics on food intake, resting energy expenditure and physical activity. European Journal of Clinical Nutrition, 68, 146–152.
- Curtis, J., Newall, H. D. & Samaras, K. (2012). The heart of the matter: Cardiometabolic care in youth with psychosis. Early Intervention in Psychiatry, 6, 347–353.
- De Hert, M., Dekker, J. M., Wood, D., Kahl, K. G., Holt, R. I. G. & Möller, H. J. (2011). Cardiovascular disease and diabetes in people with severe mental illness position statement from the European Psychiatric Association (EPA). Giornale Italiano di Psicopatologia, 17, 62–77.
- De Hert, M., Detraux, J., Winkel, R., Weiping, Y. & Correll, C. U. (2012). Metabolic and cardiovascular adverse effects associated with antipsychotic drugs. Nature Reviews Endocrinology, 8, 114–126.
- Druss, B. G., Bradford, D. & Rosenheck, R. A. (2001). Quality of medical care and excess mortality in older patients with mental disorders. Archives of General Psychiatry, 58, 565–572.
- Genuth, S., Alberti, K. G., Bennett, P. et al; Committee Expert on the Diagnosis and Classification of Diabetes Mellitus (2003). Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care, 26, 3160–3167.
- Grover, S., Nebhinani, N., Chakrabarti, S., Parakh, P. & Ghormode, D. (2012). Metabolic syndrome in antipsychotic naïve patients diagnosed with schizophrenia. Early Intervention in Psychiatry, 6, 326–331.
- Happel, B., Scott, D., Platania-Phung, C. & Nankivell, J. (2011). Nurses views on physical activity for people with serious mental illness. Mental Health and Physical Activity, 5, 4–12.
10.1016/j.mhpa.2012.02.005 Google Scholar
- Happell, B., Ewart, S. B., Platania-Phung, C. & Stanton, R. (2016). Participative mental health consumer research for improving physical health care: An integrative review. International Journal of Mental Health Nursing, 25, 399–408.
- Holt, R. I., Preveler, R. C. & Byrne, C. D. (2004). Schizophrenia, the metabolic syndrome and diabetes. Diabetic Medicine, 21, 515–523.
- Lambert, T. J., Chapman, L. H. & Consensus Working Group (2004). Diabetes, psychotic disorders and antipsychotic therapy: A consensus statement. Medical Journal of Australia, 181, 544–548.
- Leucht, S., Burkard, T., Henderson, J., Maj, M. & Sartorius, N. (2007). Physical illness and schizophrenia: A review of the literature. Acta Psychiatrica Scandinavica, 116, 317–333.
- Levesque, J. & Lamarche, B. (2008). The metabolic syndrome: Definitions, prevalence and management. Journal of Nutrigenet and Nutrigenomics, 1, 100–108.
- Liu, N. H., Daumit, G. L., Dua, T. et al. (2017). Excess mortality in persons with severe mental disorders: A multilevel intervention framework and priorities for clinical practice, policy and research agendas. World Psychiatry, 16, 30–40.
- Maj, M. (2009). Physical health in persons with severe mental illness: A public health and ethical priority. World Psychiatry, 8, 1–2.
- Malhotra, N., Grover, S., Chakrabarti, S. & Kulhara, P. (2013). Metabolic syndrome in schizophrenia. Indian Journal Psychological Medicine, 35, 227–240.
- Miccoli, R., Bianchi, C., Odoguardi, L. et al. (2005). Prevalence of the metabolic syndrome among Italian adults according to ATP III definition. Nutrition, Metabolism and Cardiovascular Diseases, 15, 250–254.
- National Cholesterol Education Program (NCEP): Expert Panel on Detection and Treatment of High Blood Cholesterol in Adults (2002). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation, 106, 3143–3421.
- O'Callaghan, C., Liew, A., Yusof, M. et al. (2011). Screening for metabolic syndrome in long-term psychiatric illness: Audit of patients receiving depot antipsychotic medication at a psychiatry clinic. The European Journal of Psychiatry, 25, 213–222.
- Pallava, A., Chadda, R. K., Sood, M. & Lakshmy, R. (2012). Metabolic syndrome in schizophrenia: A comparative study of antipsychotic-free/naïve and antipsychotic-treated patients from India. Nordic Journal of Psychiatry, 66, 215–221.
- Parks, J., Svendsen, D., Singer, P. & Foti, M. E. (2006). Morbidity and Mortality in People with Serious Mental Illness. Alexandria: National Association of State Mental Health Program Directors (NASMHPD), Medical Directors Council.
- Piccinelli, M., Politi, P. & Barale, F. (2002). Focus on psychiatry in Italy. The British Journal of Psychiatry, 181, 538–544.
- Reist, C., Mintz, J., Albers, L., Jamal, M., Szabo, S. & Ozdemir, V. (2007). Second-generation antipsychotic exposure and metabolic-related disorders in patients with schizophrenia: An observational pharmacoepidemiology study from 1988 to 2002. Journal of Psychopharmacology, 27, 46–51.
- Rosenbaum, S., Nijjar, S., Watkins, A. et al. (2014). Nurse-assessed metabolic monitoring: A file audit of risk factor prevalence and impact of an intervention to enhance measurement of waist circumference. International Journal of Mental Health Nursing, 23, 252–256.
- Saha, S., Chant, D. & McGrath, J. A. (2007). Systematic review of mortality in schizophrenia: Is the differential mortality gap worsening over time?. Archives of General Psychiatry, 64, 1123–1131.
- Sahoo, S., Ameen, S. & Akhtar, S. (2007). Metabolic syndrome in drug-naïve first episode psychosis treated with atypical antipsychotics. Australian and New Zealand Journal of Psychiatry, 41, 629.
- Santini, I., Stratta, P., D'onofrio, S. et al. (2016). The metabolic syndrome in an Italian psychiatric sample: A retrospective chart review of inpatients treated with antipsychotics. Rivista di Psichiatria, 51, 37–42.
- Smith, D. J., Langan, J., McLean, G., Guthrie, B. & Mercer, S. W. (2013). Schizophrenia is associated with excess multiple physical-health comorbidities but low levels of recorded cardiovascular disease in primary care: Cross-sectional study. British Medical Journal Open, 3, e002808.
- Stahl, S. M., Mignon, L. & Meyer, J. M. (2009). Which comes first: Atypical antipsychotic treatment or cardiometabolic risk? Acta Psychiatrica Scandinavica, 119, 171–179.
- Thornicroft, G. (2011). Physical health disparities and mental illness: The scandal of premature mortality. The British Journal of Psychology, 199, 441–442.
10.1192/bjp.bp.111.092718 Google Scholar
- Vampfort, D., Probst, M., Scheewe, T. W. et al. (2013). Relationships between physical fitness, physical activity, smoking and metabolic and mental health parameters in people with schizophrenia. Psychiatry Research, 207, 25–32.
- Vreeland, B. (2007). Treatment decisions in major mental illness: Weighing the outcomes. Journal of Clinical Psychiatry, 68, 5–11.
- Werneke, U., Taylor, D. & Sanders, T. A. B. (2013). Behavioural interventions for antipsychotic induced appetite changes. Current Psychiatric Reports, 15, 347.
- World Health Organization (2010). Global Recommendations on Physical Activity for Health. Geneva: World Health Organization.
- Wu, R. R., Zhao, J. P., Jin, H. et al. (2008). Lifestyle intervention and metformin for treatment of antipsychotic-induced weight gain: A randomized control trial. JAMA, 299, 185–193.