STroke imAging pRevention and treatment (START): A longitudinal stroke cohort study: Clinical trials protocol
Corresponding Author
Leeanne M. Carey
National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
Department of Occupational Therapy, School of Allied Health, La Trobe University, Bundoora, Vic., Australia
Correspondence: Leeanne M. Carey, National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre-Austin Campus, 245 Burgundy Street, Heidelberg, Vic. 3084, Australia.
E-mail: [email protected]
Search for more papers by this authorSheila Crewther
National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
School of Psychological Sciences, La Trobe University, Bundoora, Vic., Australia
Search for more papers by this authorOlivier Salvado
Preventative Health National Research Flagship, The Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Herston, Qld, Australia
Search for more papers by this authorThomas Lindén
National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
Search for more papers by this authorAlan Connelly
Brain Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
Search for more papers by this authorWilliam Wilson
Preventative Health National Research Flagship, Neurodegenerative Diseases, Mental Disorders and Brain Health, CSIRO, North Ryde, NSW, Australia
Search for more papers by this authorDavid W. Howells
National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
Search for more papers by this authorLeonid Churilov
National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
Search for more papers by this authorHenry Ma
National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
Stroke Unit, Monash Medical Centre, Department of Medicine, Monash University, Clayton, Vic., Australia
Search for more papers by this authorTamara Tse
National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
Department of Occupational Therapy, School of Allied Health, La Trobe University, Bundoora, Vic., Australia
Search for more papers by this authorStephen Rose
Preventative Health National Research Flagship, The Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Herston, Qld, Australia
Search for more papers by this authorSusan Palmer
National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
Search for more papers by this authorPierrick Bougeat
Preventative Health National Research Flagship, The Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Herston, Qld, Australia
Search for more papers by this authorBruce C. V. Campbell
Department of Medicine, Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
Search for more papers by this authorSoren Christensen
Department of Medicine, Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
Search for more papers by this authorS. Lance Macaulay
Preventative Health National Research Flagship, Neurodegenerative Diseases, Mental Disorders and Brain Health, CSIRO, Parkville, Vic., Australia
Search for more papers by this authorJenny Favaloro
National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
Search for more papers by this authorVictoria O' Collins
National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
Search for more papers by this authorSimon McBride
Preventative Health National Research Flagship, The Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Herston, Qld, Australia
Search for more papers by this authorSusan Bates
Neuroscience Trials Australia, Melbourne Brain Centre – Austin Campus, Heidelberg, Vic., Australia
Search for more papers by this authorElise Cowley
Neuroscience Trials Australia, Melbourne Brain Centre – Austin Campus, Heidelberg, Vic., Australia
Search for more papers by this authorHelen Dewey
Department of Neurology, Austin Health, Heidelberg, Vic., Australia
Search for more papers by this authorTissa Wijeratne
Department of Neurology, Western Hospital, Western Health, Melbourne, Vic., Australia
Search for more papers by this authorThanh G. Phan
Stroke Unit, Monash Medical Centre, Department of Medicine, Monash University, Clayton, Vic., Australia
Search for more papers by this authorBernard Yan
Department of Medicine, Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
Search for more papers by this authorMark W. Parsons
Department of Neurology, John Hunter Hospital, University of Newcastle, Newcastle, NSW, Australia
Search for more papers by this authorChris Bladin
Department of Neurology, Box Hill Hospital, Eastern Health, Melbourne, Vic., Australia
Search for more papers by this authorP. Alan Barber
Department of Neurology, Auckland City Hospital, Auckland, New Zealand
Search for more papers by this authorStephen Read
Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Qld, Australia
Search for more papers by this authorAndrew Wong
Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Qld, Australia
Search for more papers by this authorAndrew Lee
Flinders Comprehensive Stroke Centre, Flinders Medical Centre and University, Adelaide, SA
Search for more papers by this authorTim Kleinig
Department of Neurology, Royal Adelaide Hospital, Adelaide, SA, Australia
Search for more papers by this authorGraeme J. Hankey
School of Medicine and Pharmacology, The University of Western Australia, Perth, WA, Australia
Department of Neurology, Sir Charles Gairdner Hospital, Perth, WA, Australia
Search for more papers by this authorDavid Blacker
Department of Neurology, Sir Charles Gairdner Hospital, Perth, WA, Australia
Search for more papers by this authorRomesh Markus
Department of Neurology, St. Vincent's Hospital, Sydney, NSW, Australia
Search for more papers by this authorJames Leyden
Department of Neurology, Lyell McEwin Hospital, Adelaide, SA, Australia
Search for more papers by this authorMartin Krause
Department of Neurology, Royal North Shore Hospital, Sydney, NSW, Australia
Search for more papers by this authorRohan Grimley
Department of Neurology, Nambour General Hospital, Nambour, Qld, Australia
Search for more papers by this authorNeil Mahant
Department of Neurology, Westmead Hospital, Sydney, NSW, Australia
Search for more papers by this authorJim Jannes
Department of Neurology, The Queen Elizabeth Hospital, SA
Search for more papers by this authorJonathan Sturm
Department of Neurology, Gosford Hospital, Gosford, NSW, Australia
Search for more papers by this authorStephen M. Davis
Department of Medicine, Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
Co-chair of START collaborative study group.Search for more papers by this authorGeoffrey A. Donnan
National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
Co-chair of START collaborative study group.Search for more papers by this authorCorresponding Author
Leeanne M. Carey
National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
Department of Occupational Therapy, School of Allied Health, La Trobe University, Bundoora, Vic., Australia
Correspondence: Leeanne M. Carey, National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre-Austin Campus, 245 Burgundy Street, Heidelberg, Vic. 3084, Australia.
E-mail: [email protected]
Search for more papers by this authorSheila Crewther
National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
School of Psychological Sciences, La Trobe University, Bundoora, Vic., Australia
Search for more papers by this authorOlivier Salvado
Preventative Health National Research Flagship, The Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Herston, Qld, Australia
Search for more papers by this authorThomas Lindén
National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
Search for more papers by this authorAlan Connelly
Brain Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
Search for more papers by this authorWilliam Wilson
Preventative Health National Research Flagship, Neurodegenerative Diseases, Mental Disorders and Brain Health, CSIRO, North Ryde, NSW, Australia
Search for more papers by this authorDavid W. Howells
National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
Search for more papers by this authorLeonid Churilov
National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
Search for more papers by this authorHenry Ma
National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
Stroke Unit, Monash Medical Centre, Department of Medicine, Monash University, Clayton, Vic., Australia
Search for more papers by this authorTamara Tse
National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
Department of Occupational Therapy, School of Allied Health, La Trobe University, Bundoora, Vic., Australia
Search for more papers by this authorStephen Rose
Preventative Health National Research Flagship, The Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Herston, Qld, Australia
Search for more papers by this authorSusan Palmer
National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
Search for more papers by this authorPierrick Bougeat
Preventative Health National Research Flagship, The Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Herston, Qld, Australia
Search for more papers by this authorBruce C. V. Campbell
Department of Medicine, Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
Search for more papers by this authorSoren Christensen
Department of Medicine, Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
Search for more papers by this authorS. Lance Macaulay
Preventative Health National Research Flagship, Neurodegenerative Diseases, Mental Disorders and Brain Health, CSIRO, Parkville, Vic., Australia
Search for more papers by this authorJenny Favaloro
National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
Search for more papers by this authorVictoria O' Collins
National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
Search for more papers by this authorSimon McBride
Preventative Health National Research Flagship, The Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Herston, Qld, Australia
Search for more papers by this authorSusan Bates
Neuroscience Trials Australia, Melbourne Brain Centre – Austin Campus, Heidelberg, Vic., Australia
Search for more papers by this authorElise Cowley
Neuroscience Trials Australia, Melbourne Brain Centre – Austin Campus, Heidelberg, Vic., Australia
Search for more papers by this authorHelen Dewey
Department of Neurology, Austin Health, Heidelberg, Vic., Australia
Search for more papers by this authorTissa Wijeratne
Department of Neurology, Western Hospital, Western Health, Melbourne, Vic., Australia
Search for more papers by this authorThanh G. Phan
Stroke Unit, Monash Medical Centre, Department of Medicine, Monash University, Clayton, Vic., Australia
Search for more papers by this authorBernard Yan
Department of Medicine, Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
Search for more papers by this authorMark W. Parsons
Department of Neurology, John Hunter Hospital, University of Newcastle, Newcastle, NSW, Australia
Search for more papers by this authorChris Bladin
Department of Neurology, Box Hill Hospital, Eastern Health, Melbourne, Vic., Australia
Search for more papers by this authorP. Alan Barber
Department of Neurology, Auckland City Hospital, Auckland, New Zealand
Search for more papers by this authorStephen Read
Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Qld, Australia
Search for more papers by this authorAndrew Wong
Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Qld, Australia
Search for more papers by this authorAndrew Lee
Flinders Comprehensive Stroke Centre, Flinders Medical Centre and University, Adelaide, SA
Search for more papers by this authorTim Kleinig
Department of Neurology, Royal Adelaide Hospital, Adelaide, SA, Australia
Search for more papers by this authorGraeme J. Hankey
School of Medicine and Pharmacology, The University of Western Australia, Perth, WA, Australia
Department of Neurology, Sir Charles Gairdner Hospital, Perth, WA, Australia
Search for more papers by this authorDavid Blacker
Department of Neurology, Sir Charles Gairdner Hospital, Perth, WA, Australia
Search for more papers by this authorRomesh Markus
Department of Neurology, St. Vincent's Hospital, Sydney, NSW, Australia
Search for more papers by this authorJames Leyden
Department of Neurology, Lyell McEwin Hospital, Adelaide, SA, Australia
Search for more papers by this authorMartin Krause
Department of Neurology, Royal North Shore Hospital, Sydney, NSW, Australia
Search for more papers by this authorRohan Grimley
Department of Neurology, Nambour General Hospital, Nambour, Qld, Australia
Search for more papers by this authorNeil Mahant
Department of Neurology, Westmead Hospital, Sydney, NSW, Australia
Search for more papers by this authorJim Jannes
Department of Neurology, The Queen Elizabeth Hospital, SA
Search for more papers by this authorJonathan Sturm
Department of Neurology, Gosford Hospital, Gosford, NSW, Australia
Search for more papers by this authorStephen M. Davis
Department of Medicine, Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
Co-chair of START collaborative study group.Search for more papers by this authorGeoffrey A. Donnan
National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic., Australia
Co-chair of START collaborative study group.Search for more papers by this authorAbstract
Rationale
Stroke and poststroke depression are common and have a profound and ongoing impact on an individual's quality of life. However, reliable biological correlates of poststroke depression and functional outcome have not been well established in humans.
Aims
Our aim is to identify biological factors, molecular and imaging, associated with poststroke depression and recovery that may be used to guide more targeted interventions.
Design
In a longitudinal cohort study of 200 stroke survivors, the START – STroke imAging pRevention and Treatment cohort, we will examine the relationship between gene expression, regulator proteins, depression, and functional outcome. Stroke survivors will be investigated at baseline, 24 h, three-days, three-months, and 12 months poststroke for blood-based biological associates and at days 3–7, three-months, and 12 months for depression and functional outcomes. A sub-group (n = 100), the PrePARE: Prediction and Prevention to Achieve optimal Recovery Endpoints after stroke cohort, will also be investigated for functional and structural changes in putative depression-related brain networks and for additional cognition and activity participation outcomes. Stroke severity, diet, and lifestyle factors that may influence depression will be monitored. The impact of depression on stroke outcomes and participation in previous life activities will be quantified.
Study Outcomes
Clinical significance lies in the identification of biological factors associated with functional outcome to guide prevention and inform personalized and targeted treatments. Evidence of associations between depression, gene expression and regulator proteins, functional and structural brain changes, lifestyle and functional outcome will provide new insights for mechanism-based models of poststroke depression.
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Citing Literature
