The Distribution of HLA-DRB4 Alleles Among HLA-DRB1*07:01-Positive Haplotypes in Saudi Arabia
Sheerin A. Alandejani
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City—Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Search for more papers by this authorFatma Aytül Uyar
Department of Physiology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
Search for more papers by this authorAbdullah Alrasheed
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City—Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Search for more papers by this authorMohammed Alghamdi
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City—Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Search for more papers by this authorAsma Albaihed
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City—Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Search for more papers by this authorAbdullah S. Matyuri
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City—Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Search for more papers by this authorAbdulrahman Alkhaibari
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City—Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Search for more papers by this authorAishah Alanazi
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City—Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Search for more papers by this authorMohammed Alzahrani
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City—Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Search for more papers by this authorAbdullah Alshubaili
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City—Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Search for more papers by this authorHanan Anazi
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City—Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Search for more papers by this authorCorresponding Author
Ali H. Hajeer
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City—Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
RAK Medical & Health Sciences University, Ras Al Khaimah, UAE
Search for more papers by this authorSheerin A. Alandejani
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City—Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Search for more papers by this authorFatma Aytül Uyar
Department of Physiology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
Search for more papers by this authorAbdullah Alrasheed
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City—Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Search for more papers by this authorMohammed Alghamdi
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City—Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Search for more papers by this authorAsma Albaihed
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City—Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Search for more papers by this authorAbdullah S. Matyuri
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City—Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Search for more papers by this authorAbdulrahman Alkhaibari
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City—Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Search for more papers by this authorAishah Alanazi
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City—Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Search for more papers by this authorMohammed Alzahrani
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City—Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Search for more papers by this authorAbdullah Alshubaili
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City—Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Search for more papers by this authorHanan Anazi
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City—Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Search for more papers by this authorCorresponding Author
Ali H. Hajeer
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City—Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
RAK Medical & Health Sciences University, Ras Al Khaimah, UAE
Search for more papers by this authorFunding: The authors received no specific funding for this work.
ABSTRACT
This study investigates the distribution of human leukocyte antigen (HLA)-DRB4 alleles in HLA-DRB1*07:01-positive haplotypes within a Saudi cohort of 313 individuals. It identifies strong linkage disequilibrium between HLA-DRB1*07:01 and specific alleles. The most prevalent HLA-DRB1∼DQB1 combination identified is DRB1*07:01∼DQB1*02:02. Additionally, for the HLA-DRB1*07:01∼DQB1*03:03 association, DRB4*01:01 was found to be more common than the DRB4*01:03N allele. The most frequently observed extended haplotype is HLA-A*02:01∼C*06:02∼B*50:01∼DRB1*07:01∼DRB4*01:03∼DQA1*02:01∼DQB1*02:02∼DPA1*01:03∼DPB1*04:01. These findings emphasize the distinct genetic characteristics of the Saudi population and contribute to understanding haplotypic diversity, particularly the prevalence of HLA-DR7-related alleles and their implications for disease susceptibility and transplantation compatibility.
Conflicts of Interest
The authors declare no conflicts of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
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