Immunopathology of Kikuchi–Fujimoto disease: A reappraisal using novel immunohistochemistry markers
Correction(s) for this article
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Correction to ‘Immunopathology of Kikuchi–Fujimoto disease: A reappraisal using novel immunohistochemistry markers’
- Volume 84Issue 4Histopathology
- pages: 719-719
- First Published online: January 16, 2024
Narittee Sukswai
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TV, USA
Department of Pathology, Chulalongkorn University, Bangkok, Thailand
Search for more papers by this authorHye Ra Jung
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TV, USA
Department of Pathology, Keimyung University, Dongsan Medical Center, Seoul, South Korea
Search for more papers by this authorSamir S Amr
Department of Pathology, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia
Search for more papers by this authorSiok Bian Ng
Department of Pathology, National University Hospital, Singapore
Search for more papers by this authorSalwa S Sheikh
Department of Pathology, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia
Search for more papers by this authorKirill Lyapichev
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TV, USA
Search for more papers by this authorSiba El Hussein
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TV, USA
Search for more papers by this authorSanam Loghavi
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TV, USA
Search for more papers by this authorRose Lou Marie C Agbay
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TV, USA
Department of Pathology, The Medical City Hospital, Manila, Philippines
Search for more papers by this authorRoberto N Miranda
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TV, USA
Search for more papers by this authorL Jeffrey Medeiros
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TV, USA
Search for more papers by this authorCorresponding Author
Joseph D Khoury
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TV, USA
Address for correspondence author: Address for correspondence author: Joseph D. Khoury, MD, The University of Texas MD Anderson Cancer Center, Department of Hematopathology, 1515 Holcombe Boulevard, MS-072, Houston, TX 77030, USA. e-mail: [email protected]
Search for more papers by this authorNarittee Sukswai
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TV, USA
Department of Pathology, Chulalongkorn University, Bangkok, Thailand
Search for more papers by this authorHye Ra Jung
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TV, USA
Department of Pathology, Keimyung University, Dongsan Medical Center, Seoul, South Korea
Search for more papers by this authorSamir S Amr
Department of Pathology, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia
Search for more papers by this authorSiok Bian Ng
Department of Pathology, National University Hospital, Singapore
Search for more papers by this authorSalwa S Sheikh
Department of Pathology, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia
Search for more papers by this authorKirill Lyapichev
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TV, USA
Search for more papers by this authorSiba El Hussein
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TV, USA
Search for more papers by this authorSanam Loghavi
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TV, USA
Search for more papers by this authorRose Lou Marie C Agbay
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TV, USA
Department of Pathology, The Medical City Hospital, Manila, Philippines
Search for more papers by this authorRoberto N Miranda
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TV, USA
Search for more papers by this authorL Jeffrey Medeiros
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TV, USA
Search for more papers by this authorCorresponding Author
Joseph D Khoury
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TV, USA
Address for correspondence author: Address for correspondence author: Joseph D. Khoury, MD, The University of Texas MD Anderson Cancer Center, Department of Hematopathology, 1515 Holcombe Boulevard, MS-072, Houston, TX 77030, USA. e-mail: [email protected]
Search for more papers by this authorAbstract
Aims
Kikuchi–Fujimoto disease (KFD) is a self-limited disease characterised by destruction of the lymph node parenchyma. Few studies have assessed the immunohistological features of KFD, and most employed limited antibody panels that lacked many of the novel immunohistochemistry markers currently available.
Methods and results
We used immunohistochemistry to reappraise the microanatomical distribution of plasmacytoid dendritic cells (pDCs), follicular helper T cells and cytotoxic T cells, B cells, follicular dendritic cell (FDC) meshworks, and histiocytes in lymph nodes involved by KFD. The study group consisted of 138 KFD patients (89 women; 64.5%) with a median age of 27 years (range, 3–50 years). Cervical lymph nodes were most commonly involved, in 108 (78.3%) patients. The numbers of pDCs were increased, predominantly around and within apoptotic areas and the paracortex, and tapering off within xanthomatous areas. pDCs formed sizeable tight clusters, most notably around apoptotic/necrotic areas. T cells consisted mostly of CD8-positive cells with predominant expression of T-cell receptor-β. There were notable increases in the numbers of CD8-positive T cells within lymphoid follicles, and their numbers correlated with alterations in FDC meshworks (P < 0.001). The number of follicular helper T cells was decreased within distorted FDC meshworks. CD21 highlighted frequent distortion of FDC meshworks, even in lymph node tissue that was distant from apoptotic/necrotic areas. Distorted FDC meshworks spanned all morphological patterns, and FDC meshwork characteristics (intact; distorted; remnant/nearly absent) correlated with morphological patterns (P < 0.01).
Conclusions
The immunohistological landscape of KFD is complex and characterised by increased numbers of pDCs that frequently cluster around apoptotic/necrotic foci, increased numbers of cytotoxic T cells, and substantial distortion of FDC meshworks.
Conflicts of interest
None of the authors has declared any competing financial interests.
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