Reciprocal relationship of Tn/NF-κB and sTn as an indicator of the prognosis of oral squamous cell carcinoma
Chi-Yu Lin
Graduate Institute of Life Sciences, National Defense Medical Centre, Taipei, Taiwan
Department of Biochemistry, Medical College, Taipei Medical University, Taipei, Taiwan
Search for more papers by this authorJar-Yi Ho
Graduate Institute of Life Sciences, National Defense Medical Centre, Taipei, Taiwan
Department of Pathology and Graduate School of Pathology, National Defense Medical Centre and Tri-Service General Hospital, Taipei, Taiwan
Search for more papers by this authorMeng-Ti Hsieh
Institute of Cancer Biology and Drug Discovery, Taipei Medical University, Taipei, Taiwan
Search for more papers by this authorHsiao-Ling Chiang
Graduate Institute of Life Sciences, National Defense Medical Centre, Taipei, Taiwan
Department of Biochemistry, Medical College, Taipei Medical University, Taipei, Taiwan
Search for more papers by this authorJei-Min Chuang
Department of Biochemistry, Medical College, Taipei Medical University, Taipei, Taiwan
Search for more papers by this authorJacqueline Whang-Peng
Centre of Excellence for Cancer Research, Taipei Medical University, Taipei, Taiwan
Search for more papers by this authorYun-Ching Chang
Department of Medical Research and Education, Taipei Veterans General Hospital, Taichung, Taiwan
Search for more papers by this authorYi-Han Tseng
Department of Pathology and Graduate School of Pathology, National Defense Medical Centre and Tri-Service General Hospital, Taipei, Taiwan
Search for more papers by this authorCorresponding Author
Su-Feng Chen
Department of Dental Hygiene, China Medical University, Taichung, Taiwan
Address for correspondence: J Hwang, Department of Biochemistry, Medical College, Taipei Medical University, No. 250, Wusing Street, Sinyi District, Taipei, Taiwan 11031, Taiwan. e-mail: [email protected]
Co-correspondence: Su-Feng Chen. e-mail: [email protected], Shin Nieh. e-mail: [email protected]
Search for more papers by this authorCorresponding Author
Shin Nieh
Department of Pathology and Graduate School of Pathology, National Defense Medical Centre and Tri-Service General Hospital, Taipei, Taiwan
Address for correspondence: J Hwang, Department of Biochemistry, Medical College, Taipei Medical University, No. 250, Wusing Street, Sinyi District, Taipei, Taiwan 11031, Taiwan. e-mail: [email protected]
Co-correspondence: Su-Feng Chen. e-mail: [email protected], Shin Nieh. e-mail: [email protected]
Search for more papers by this authorCorresponding Author
Jaulang Hwang
Department of Biochemistry, Medical College, Taipei Medical University, Taipei, Taiwan
Address for correspondence: J Hwang, Department of Biochemistry, Medical College, Taipei Medical University, No. 250, Wusing Street, Sinyi District, Taipei, Taiwan 11031, Taiwan. e-mail: [email protected]
Co-correspondence: Su-Feng Chen. e-mail: [email protected], Shin Nieh. e-mail: [email protected]
Search for more papers by this authorChi-Yu Lin
Graduate Institute of Life Sciences, National Defense Medical Centre, Taipei, Taiwan
Department of Biochemistry, Medical College, Taipei Medical University, Taipei, Taiwan
Search for more papers by this authorJar-Yi Ho
Graduate Institute of Life Sciences, National Defense Medical Centre, Taipei, Taiwan
Department of Pathology and Graduate School of Pathology, National Defense Medical Centre and Tri-Service General Hospital, Taipei, Taiwan
Search for more papers by this authorMeng-Ti Hsieh
Institute of Cancer Biology and Drug Discovery, Taipei Medical University, Taipei, Taiwan
Search for more papers by this authorHsiao-Ling Chiang
Graduate Institute of Life Sciences, National Defense Medical Centre, Taipei, Taiwan
Department of Biochemistry, Medical College, Taipei Medical University, Taipei, Taiwan
Search for more papers by this authorJei-Min Chuang
Department of Biochemistry, Medical College, Taipei Medical University, Taipei, Taiwan
Search for more papers by this authorJacqueline Whang-Peng
Centre of Excellence for Cancer Research, Taipei Medical University, Taipei, Taiwan
Search for more papers by this authorYun-Ching Chang
Department of Medical Research and Education, Taipei Veterans General Hospital, Taichung, Taiwan
Search for more papers by this authorYi-Han Tseng
Department of Pathology and Graduate School of Pathology, National Defense Medical Centre and Tri-Service General Hospital, Taipei, Taiwan
Search for more papers by this authorCorresponding Author
Su-Feng Chen
Department of Dental Hygiene, China Medical University, Taichung, Taiwan
Address for correspondence: J Hwang, Department of Biochemistry, Medical College, Taipei Medical University, No. 250, Wusing Street, Sinyi District, Taipei, Taiwan 11031, Taiwan. e-mail: [email protected]
Co-correspondence: Su-Feng Chen. e-mail: [email protected], Shin Nieh. e-mail: [email protected]
Search for more papers by this authorCorresponding Author
Shin Nieh
Department of Pathology and Graduate School of Pathology, National Defense Medical Centre and Tri-Service General Hospital, Taipei, Taiwan
Address for correspondence: J Hwang, Department of Biochemistry, Medical College, Taipei Medical University, No. 250, Wusing Street, Sinyi District, Taipei, Taiwan 11031, Taiwan. e-mail: [email protected]
Co-correspondence: Su-Feng Chen. e-mail: [email protected], Shin Nieh. e-mail: [email protected]
Search for more papers by this authorCorresponding Author
Jaulang Hwang
Department of Biochemistry, Medical College, Taipei Medical University, Taipei, Taiwan
Address for correspondence: J Hwang, Department of Biochemistry, Medical College, Taipei Medical University, No. 250, Wusing Street, Sinyi District, Taipei, Taiwan 11031, Taiwan. e-mail: [email protected]
Co-correspondence: Su-Feng Chen. e-mail: [email protected], Shin Nieh. e-mail: [email protected]
Search for more papers by this authorAbstract
Aims
In order to determine whether the expression of tumour-associated carbohydrate antigens (Tn/sTn) and a representative inflammation marker, nuclear factor-κB (NF-κB), is associated with the invasiveness of oral squamous cell carcinoma (OSCC), this study has attempted to investigate the correlation of the aforementioned markers with the well-established invasive pattern grading score (IPGS) and clinicopathological parameters.
Methods and results
Specimens from 143 OSCC patients with classified clinicopathological parameters and IPGS were stained immunohistochemically using anti-Tn, sTn and NF-κB antibodies. Our results showed that the expression of both Tn and NF-κB was correlated positively with staging (P = 0.036; P = 0.015), recurrence (P < 0.001; P < 0.001) and distant metastasis (P = 0.005; P = 0.009), as well as with IPGS, while the expression of sTn was correlated inversely. In addition, poor survival was associated with overexpression of Tn and NF-κB but not with expression of sTn.
Conclusions
Our results indicate that a reciprocal relationship between Tn and sTn expression may serve as a reliable indicator for OSCC prognostic evaluation. In addition, expression of Tn rather than sTn may play an important role in deeply invasive OSCC via regulation of NF-κB signalling.
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