ORIGINAL ARTICLE: EPIDEMIOLOGY, CLINICAL PRACTICE AND HEALTH

Relationships between serum brain-derived neurotrophic factor concentration and parameters for health scores in community-dwelling older adults

Corresponding Author

Mitsugu Hachisu

[email protected]

orcid.org/0000-0002-1240-1157

Department of Pharmaceutical therapeutics, Division of Clinical Pharmacy, Pharmacy School, Showa University, Tokyo, Japan

Correspondence: Dr Mitsugu Hachisu PhD, Department of Pharmaceutical Therapeutics, Division of Clinical Pharmacy, Pharmacy School, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. Email: [email protected]Search for more papers by this author

Masahiro Hashizume,

Masahiro Hashizume

Department of Psychosomatic Medicine, School of Medicine, Toho University, Tokyo, Japan

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Hisashi Kawai,

Hisashi Kawai

Human Care Research Team, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

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Hirohiko Hirano,

Hirohiko Hirano

Department of Dentistry, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

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Motonaga Kojima,

Motonaga Kojima

Human Care Research Team, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

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Yoshinori Fujiwara,

Yoshinori Fujiwara

Research Team for Social Participation and Community Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

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Shuichi Obuchi,

Shuichi Obuchi

Human Care Research Team, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

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Kazushige Ihara,

Kazushige Ihara

Department of Public Health, School of Medicine, Toho University, Tokyo, Japan

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Mitsugu Hachisu,

Corresponding Author

Mitsugu Hachisu

[email protected]

orcid.org/0000-0002-1240-1157

Department of Pharmaceutical therapeutics, Division of Clinical Pharmacy, Pharmacy School, Showa University, Tokyo, Japan

Masahiro Hashizume,

Masahiro Hashizume

Department of Psychosomatic Medicine, School of Medicine, Toho University, Tokyo, Japan

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Hisashi Kawai,

Hisashi Kawai

Human Care Research Team, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

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Hirohiko Hirano,

Hirohiko Hirano

Department of Dentistry, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

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Motonaga Kojima,

Motonaga Kojima

Human Care Research Team, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

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Yoshinori Fujiwara,

Yoshinori Fujiwara

Research Team for Social Participation and Community Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

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Shuichi Obuchi,

Shuichi Obuchi

Human Care Research Team, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

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Kazushige Ihara,

Kazushige Ihara

Department of Public Health, School of Medicine, Toho University, Tokyo, Japan

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First published: 08 December 2017

https://doi.org/10.1111/ggi.13210

Citations: 6

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Abstract

Aim

Brain-derived neurotrophic factor (BDNF) have been implicated in the progression of neuronal survival, phenotyping differentiation and maintenance of various neurons, as well as neurogenesis. We studied how BDNF affects health parameters of older adults by carrying out a health examination of community-dwelling older adults.

Methods

We measured the serum BDNF concentration of 898 older adults aged 65–84 years who participated in regional health examinations in the Tokyo area and also measured various parameters, such as the thickness of the quadriceps femoris, percentage of body fat, body mass index, grip strength, frequency of walking, and use of sleeping drugs and steroidal anti-inflammatory drugs.

Results

We obtained significant relationships between serum BDNF values and thickness of the quadriceps muscle, body mass index or percentage of body fat. Individuals holding onto something when they stood up had lower serum BDNF values than individuals not holding onto something when they stood up. Smokers had higher serum BDNF values than non-smokers.

Conclusions

Older adults who had higher serum BDNF had bigger quadriceps muscles, higher body mass index and higher body fat rate, and were also able to stand up without holding onto something from a sitting position. Geriatr Gerontol Int 2018; 18: 456–461.

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Volume18, Issue3

March 2018

Pages 456-461

Relationships between serum brain-derived neurotrophic factor concentration and parameters for health scores in community-dwelling older adults

Abstract

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References

Citing Literature

References

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Relationships between serum brain-derived neurotrophic factor concentration and parameters for health scores in community-dwelling older adults

Abstract

Aim

Methods

Results

Conclusions

References

Citing Literature

References

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