Correspondence: R. Linker, Department of Neurology, Schwabachanlage 6, 91054 Erlangen, Germany (tel.: +49-9131-85-42187; fax: +49-9131-85-34510; e-mail: [email protected]).Search for more papers by this author

D.-H. Lee,

D.-H. Lee

Department of Neurology, University of Erlangen, Erlangen, Germany

Search for more papers by this author

K. Huhn,

K. Huhn

Department of Neurology, University of Erlangen, Erlangen, Germany

These authors contributed equally.Search for more papers by this author

R. Lämmer,

R. Lämmer

Department of Ophthalmology, University of Erlangen, Erlangen, Germany

These authors contributed equally.Search for more papers by this author

T. Oberwahrenbrock,

T. Oberwahrenbrock

NeuroCure Clinical Research Center, Max Delbrück Center for Molecular Medicine, University of Berlin, Berlin, Germany

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A. Lämmer,

A. Lämmer

Department of Neurology, University of Erlangen, Erlangen, Germany

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A. Waschbisch,

A. Waschbisch

Department of Neurology, University of Erlangen, Erlangen, Germany

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D. Gosar,

D. Gosar

Department of Neurology, University of Erlangen, Erlangen, Germany

University Medical Centre Ljubljana, Ljubljana, Slovenia

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A. Brandt,

A. Brandt

NeuroCure Clinical Research Center, Max Delbrück Center for Molecular Medicine, University of Berlin, Berlin, Germany

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F. Paul,

F. Paul

NeuroCure Clinical Research Center, Max Delbrück Center for Molecular Medicine, University of Berlin, Berlin, Germany

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R. A. Linker,

Corresponding Author

R. A. Linker

Department of Neurology, University of Erlangen, Erlangen, Germany

D.-H. Lee,

D.-H. Lee

Department of Neurology, University of Erlangen, Erlangen, Germany

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First published: 07 August 2014

https://doi.org/10.1111/ene.12532

Citations: 9

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Abstract

Background and purpose

Some 3%−10% of patients with multiple sclerosis (MS) experience disease onset before the age of 18 years (‘early’ onset MS, EOMS). Optical coherence tomography is a non-invasive method to measure retinal nerve fibre layer thickness (RNFLT) and total macular volume (TMV) and may be useful to differentiate axonal and neuronal damage in the retina of patients with a history of EOMS. Here RNFLT and TMV in EOMS patients after a mean disease duration of 11.6 years were compared with patients with age- or disease-duration-matched later onset MS (LOMS) and healthy controls (HCs).

Methods

In this observational cross-sectional study at two German academic MS centres, RNFLT and TMV were measured by spectral-domain optical coherence tomography in 32 HCs, 36 EOMS (mean age at onset 15.5 ± 2.0 years) and 58 LOMS patients.

Results

In comparison with HCs, EOMS patients displayed a significant reduction of RNFLT and TMV independently of a history of optic neuritis. In particular, RNFLT loss in EOMS was similar to that in LOMS and TMV loss was slightly higher compared with disease-duration-matched LOMS. In a generalized estimating model, the EOMS group also displayed a similar correlation between disease duration and RNFLT or TMV loss to LOMS patients.

Conclusions

These data argue for a significant amount of axonal and neuronal damage in the retina of EOMS patients and may provide a structural basis for the observation that EOMS patients reach states of irreversible disability at a younger age than patients with LOMS.

Supporting Information

References

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Citing Literature

Volume22, Issue1

January 2015

Pages 86-92

Filename	Description
ene12532-sup-0001-AppendixS1.docWord document, 30 KB	Appendix S1. Supplemental methods of optical coherence tomography.
ene12532-sup-0002-FigureS1.tifimage/tif, 3.2 MB	Figure S1. Representative OCT data from a patient with a history of optic neuritis in the right eye.
ene12532-sup-0003-TableS1.docWord document, 51 KB	Table S1. Results for OCT parameters and visual acuity in the different cohorts.
ene12532-sup-0004-TableS2.docWord document, 49.5 KB	Table S2. Comparison of OCT parameters and visual acuity of EOMS and age- and duration-of-disease-matched LOMS.

Optical coherence tomography in patients with a history of juvenile multiple sclerosis reveals early retinal damage

Abstract

Background and purpose

Methods

Results

Conclusions

Supporting Information

References

Citing Literature

References

Information

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Optical coherence tomography in patients with a history of juvenile multiple sclerosis reveals early retinal damage

Abstract

Background and purpose

Methods

Results

Conclusions

Supporting Information

References

Citing Literature

References

Related

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