Insulin may affect breast cancer (BC) risk and prognosis. Exercise reduces insulin in obese BC survivors. We designed a randomised controlled trial to test the effect of an aerobic exercise intervention (AEI) on insulin parameters and body composition in non-obese BC women without insulin resistance. Thirty-eight BC women were randomised into an intervention group (IG = 18) or control group (CG = 20). IG participated in a structured AEI for 3 months, while CG received only the Word Cancer Research Fund/American Institute Cancer Research (WCRF/AICR) recommendation to be physically active. Fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR) index, metabolic parameters and body composition were collected at baseline and after the AEI. IG reduced insulin and HOMA-IR index by 15% and 14%, while CG increased these parameters (+12% and +16%). Insulin changed differently over time in the two randomised groups (p_interaction = .04). The between-group differences in the change of insulin (IG = −1.2 μU/ml versus CG = +0.8 μU/ml) and HOMA-IR index (IG = −0.26 versus CG = +0.25) were respectively significant (p = .04) and non-significant (p = .06). IG significantly improved lower limb muscle mass in comparison with CG (p = .03). A structured AEI may improve insulin, HOMA-IR index and body composition in non-obese BC survivors without insulin resistance.

References

Abrahamson, P. E., Gammon, M. D., Lund, M. J., Flagg, E. W., Porter, P. L., Stevens, J., … & Coates, R. J. (2006). General and abdominal obesity and survival among young women with breast cancer. Cancer Epidemiology, Biomarkers and Prevention, 15, 1871–1877.
10.1158/1055-9965.EPI-06-0356
PubMed Web of Science® Google Scholar
Aleman-Mateo, H., Lopez Teros, M. T., Ramirez, F. A., & Astiazaran-Garcia, H. (2014). Association between insulin resistance and low relative appendicular skeletal muscle mass: Evidence from a cohort study in community-dwelling older men and women participants. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 69, 871–877.
10.1093/gerona/glt193
CAS PubMed Web of Science® Google Scholar
Bacigalupo, R., Cudd, P., Littlewood, C., Bissell, P., Hawley, M. S., & Buckley, W. H. (2013). Interventions employing mobile technology for overweight and obesity: An early systematic review of randomized controlled trials. Obesity Reviews, 14, 279–291.
10.1111/obr.12006
CAS PubMed Web of Science® Google Scholar
Ballard-Barbash, R., Friedenreich, C. M., Courneya, K. S., Siddiqi, S. M., McTiernan, A., & Alfano, C. M. (2012). Physical activity, biomarkers, and disease outcomes in cancer survivors: A systematic review. Journal of the National Cancer Institute, 104, 815–840.
10.1093/jnci/djs207
PubMed Web of Science® Google Scholar
Beasley, J. M., Kwan, M. L., Chen, W. Y., Weltzien, E. K., Kroenke, C. H., Lu, W., … & Caan, B. J. (2012). Meeting the physical activity guidelines and survival after breast cancer: Findings from the after breast cancer pooling project. Breast Cancer Research and Treatment, 131, 637–643.
10.1007/s10549-011-1770-1
PubMed Web of Science® Google Scholar
Berrino, F., Villarini, A., Traina, A., Bonanni, B., Panico, S., Mano, M. P., … & Pasanisi, P. (2014). Metabolic syndrome and breast cancer prognosis. Breast Cancer Research and Treatment, 147, 159–165.
10.1007/s10549-014-3076-6
PubMed Web of Science® Google Scholar
Bruno, E., Gargano, G., Villarini, A., Traina, A., Johansson, H., Mano, M. P., … & Pasanisi, P. (2016). Adherence to WCRF/AICR cancer prevention recommendations and metabolic syndrome in breast cancer patients. International Journal of Cancer, 138, 237–244.
10.1002/ijc.29689
CAS PubMed Web of Science® Google Scholar
Courneya, K. S., Segal, R. J., Mackey, J. R., Gelmon, K., Reid, R. D., Friedenreich, C. M., … & McKenzie, D. C. (2007). Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: A multicenter randomized controlled trial. Journal of Clinical Oncology, 25, 4396–4404.
10.1200/JCO.2006.08.2024
PubMed Web of Science® Google Scholar
DeNysschen, C. A., Brown, J. K., Cho, M. H., & Dodd, M. J. (2011). Nutritional symptom and body composition outcomes of aerobic exercise in women with breast cancer. Clinical Nursing Research, 20, 29–46.
10.1177/1054773810379402
PubMed Web of Science® Google Scholar
Drenowatz, C., Hand, G. A., Sagner, M., Shook, R. P., Burgess, S., & Blair, S. N. (2015). The prospective association between different types of exercise and body composition. Medicine and Science in Sports and Exercise, 47, 2535–2541.
10.1249/MSS.0000000000000701
PubMed Web of Science® Google Scholar
Fairey, A. S., Courneya, K. S., Field, C. J., Bell, G. J., Jones, L. W., & Mackey, J. R. (2003). Effects of exercise training on fasting insulin, insulin resistance, insulin-like growth factors, and insulin-like growth factor binding proteins in postmenopausal breast cancer survivors: A randomized controlled trial. Cancer Epidemiology, Biomarkers and Prevention, 12, 721–727.
CAS PubMed Web of Science® Google Scholar
Formica, V., Tesauro, M., Cardillo, C., & Roselli, M. (2012). Insulinemia and the risk of breast cancer and its relapse. Diabetes, Obesity and Metabolism, 14, 1073–1080.
10.1111/j.1463-1326.2012.01614.x
CAS PubMed Web of Science® Google Scholar
Frank, L. L., Sorensen, B. E., Yasui, Y., Tworoger, S. S., Schwartz, R. S., Ulrich, C. M., … & McTiernan, A. (2005). Effects of exercise on metabolic risk variables in overweight postmenopausal women: A randomized clinical trial. Obesity Research, 13, 615–625.
10.1038/oby.2005.66
CAS PubMed Web of Science® Google Scholar
Ghose, A., Kundu, R., Toumeh, A., Hornbeck, C., & Mohamed, I. (2015). A review of obesity, insulin resistance, and the role of exercise in breast cancer patients. Nutrition and Cancer, 67, 197–202.
10.1080/01635581.2015.990569
CAS PubMed Web of Science® Google Scholar
Giallauria, F., Maresca, L., Vitelli, A., De Santucci, M. M., Chiodini, P., Mattiello, A., … & Vigorito, C. (2015). Exercise training improves heart rate recovery in women with breast cancer. Springerplus, 4, 388.
10.1186/s40064-015-1179-0
PubMed Web of Science® Google Scholar
Giallauria, F., Vitelli, A., Maresca, L., De Santucci, M. M., Chiodini, P., Mattiello, A., … & Vigorito, C. (2016). Exercise training improves cardiopulmonary and endothelial function in women with breast cancer: Findings from the Diana-5 dietary intervention study. Internal and Emergency Medicine, 11, 183–189.
10.1007/s11739-015-1259-8
PubMed Web of Science® Google Scholar
Goodwin, P. J., Ennis, M., Pritchard, K. I., Trudeau, M. E., Koo, J., Madarnas, Y., … & Hood, N. (2002). Fasting insulin and outcome in early-stage breast cancer: Results of a prospective cohort study. Journal of Clinical Oncology, 20, 42–51.
10.1200/JCO.2002.20.1.42
CAS PubMed Web of Science® Google Scholar
Goodwin, P. J., Ennis, M., Pritchard, K. I., Trudeau, M. E., Koo, J., Taylor, S. K., & Hood, N. (2012). Insulin- and obesity-related variables in early-stage breast cancer: Correlations and time course of prognostic associations. Journal of Clinical Oncology, 30, 164–171.
10.1200/JCO.2011.36.2723
PubMed Web of Science® Google Scholar
Harris, J. A., & Benedict, F. G. (1918). A biometric study of human basal metabolism. Proceedings of the National Academy of Sciences of the United States of America, 4, 370–373.
10.1073/pnas.4.12.370
CAS PubMed Google Scholar
Hawley, J. A. (2004). Exercise as a therapeutic intervention for the prevention and treatment of insulin resistance. Diabetes/Metabolism Research and Reviews, 20, 383–393.
10.1002/dmrr.505
CAS PubMed Web of Science® Google Scholar
Holick, C. N., Newcomb, P. A., Trentham-Dietz, A., Titus-Ernstoff, L., Bersch, A. J., Stampfer, M. J., … & Willett, W. C. (2008). Physical activity and survival after diagnosis of invasive breast cancer. Cancer Epidemiology, Biomarkers and Prevention, 17, 379–386.
PubMed Web of Science® Google Scholar
Holmes, M. D., Chen, W. Y., Feskanich, D., Kroenke, C. H., & Colditz, G. A. (2005). Physical activity and survival after breast cancer diagnosis. JAMA, 293, 2479–2486.
10.1001/jama.293.20.2479
CAS PubMed Web of Science® Google Scholar
Ibrahim, E. M., & Al-Homaidh, A. (2011). Physical activity and survival after breast cancer diagnosis: Meta-analysis of published studies. Medical Oncology, 28, 753–765.
10.1007/s12032-010-9536-x
PubMed Web of Science® Google Scholar
Irwin, M. L., Alvarez-Reeves, M., Cadmus, L., Mierzejewski, E., Mayne, S. T., Yu, H., … & Dipietro, L. (2009). Exercise improves body fat, lean mass, and bone mass in breast cancer survivors. Obesity(Silver Spring), 17, 1534–1541.
10.1038/oby.2009.18
PubMed Web of Science® Google Scholar
Irwin, M. L., Varma, K., Alvarez-Reeves, M., Cadmus, L., Wiley, A., Chung, G. G., … & Yu, H. (2009). Randomized controlled trial of aerobic exercise on insulin and insulin-like growth factors in breast cancer survivors: The Yale Exercise and Survivorship study. Cancer Epidemiology, Biomarkers and Prevention, 18, 306–313.
10.1158/1055-9965.EPI-08-0531
CAS PubMed Web of Science® Google Scholar
Jakicic, J. M., Marcus, M., Gallagher, K. I., Randall, C., Thomas, E., Goss, F. L., & Robertson, R. J. (2004). Evaluation of the SenseWear Pro Armband to assess energy expenditure during exercise. Medicine and Science in Sports and Exercise, 36, 897–904.
10.1249/01.MSS.0000126805.32659.43
PubMed Web of Science® Google Scholar
Kleinberg, D. L., Wood, T. L., Furth, P. A., & Lee, A. V. (2009). Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions. Endocrine Reviews, 30, 51–74.
10.1210/er.2008-0022
CAS PubMed Web of Science® Google Scholar
Knobf, M. T., Insogna, K., Dipietro, L., Fennie, C., & Thompson, A. S. (2008). An aerobic weight-loaded pilot exercise intervention for breast cancer survivors: Bone remodeling and body composition outcomes. Biological Research for Nursing, 10, 34–43.
10.1177/1099800408320579
PubMed Web of Science® Google Scholar
Lebrasseur, N. K., Achenbach, S. J., Melton, L. J. III, Amin, S., & Khosla, S. (2012). Skeletal muscle mass is associated with bone geometry and microstructure and serum insulin-like growth factor binding protein-2 levels in adult women and men. Journal of Bone and Mineral Research, 27, 2159–2169.
10.1002/jbmr.1666
CAS PubMed Web of Science® Google Scholar
Lewis, Z. H., Lyons, E. J., Jarvis, J. M., & Baillargeon, J. (2015). Using an electronic activity monitor system as an intervention modality: A systematic review. BMC Public Health, 15, 585.
10.1186/s12889-015-1947-3
PubMed Web of Science® Google Scholar
Ligibel, J. A., Campbell, N., Partridge, A., Chen, W. Y., Salinardi, T., Chen, H., … & Winer, E. P. (2008). Impact of a mixed strength and endurance exercise intervention on insulin levels in breast cancer survivors. Journal of Clinical Oncology, 26, 907–912.
10.1200/JCO.2007.12.7357
CAS PubMed Web of Science® Google Scholar
Lof, M., Bergstrom, K., & Weiderpass, E. (2012). Physical activity and biomarkers in breast cancer survivors: A systematic review. Maturitas, 73, 134–142.
10.1016/j.maturitas.2012.07.002
CAS PubMed Web of Science® Google Scholar
Lopez Teros, M. T., Ramirez, C. F., & Aleman-Mateo, H. (2015). Hyperinsulinemia is associated with the loss of appendicular skeletal muscle mass at 4.6 year follow-up in older men and women. Clinical Nutrition, 34, 931–936.
10.1016/j.clnu.2014.09.022
CAS PubMed Web of Science® Google Scholar
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985). Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28, 412–419.
10.1007/BF00280883
CAS PubMed Web of Science® Google Scholar
Pasanisi, P., Villarini, A., Bruno, E., Raimondi, M., Gargano, G., & Berrino, F. (2010). Nutritional advice to breast cancer survivors. Supportive Care in Cancer, 18(Suppl 2), S29–S33.
10.1007/s00520-009-0701-8
PubMed Web of Science® Google Scholar
Perez-Martin, A., Raynaud, E., & Mercier, J. (2001). Insulin resistance and associated metabolic abnormalities in muscle: Effects of exercise. Obesity Reviews, 2, 47–59.
10.1046/j.1467-789x.2001.00024.x
CAS PubMed Google Scholar
Rock, C. L., Doyle, C., Demark-Wahnefried, W., Meyerhardt, J., Courneya, K. S., Schwartz, A. L., … & Gansler, T. (2012). Nutrition and physical activity guidelines for cancer survivors. CA: A Cancer Journal for Clinicians, 62, 243–274.
10.3322/caac.21142
PubMed Web of Science® Google Scholar
Roveda, E., Vitale, J. A., Bruno, E., Montaruli, A., Pasanisi, P., Villarini, A., … & Carandente, F. (2016). Protective effect of aerobic physical activity on sleep behavior in breast cancer survivors. Integrative Cancer Therapies, ePub. doi: 10.1177/1534735416651719
10.1177/1534735416651719
PubMed Web of Science® Google Scholar
Schmitz, K. H., Ahmed, R. L., Hannan, P. J., & Yee, D. (2005). Safety and efficacy of weight training in recent breast cancer survivors to alter body composition, insulin, and insulin-like growth factor axis proteins. Cancer Epidemiology, Biomarkers and Prevention, 14, 1672–1680.
10.1158/1055-9965.EPI-04-0736
CAS PubMed Web of Science® Google Scholar
Schulz, K. F., Altman, D. G., & Moher, D. (2010). CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials. BMJ, 340, c332.
10.1136/bmj.c332
PubMed Web of Science® Google Scholar
Shafer, K. J., Siders, W. A., Johnson, L. K., & Lukaski, H. C. (2009). Validity of segmental multiple-frequency bioelectrical impedance analysis to estimate body composition of adults across a range of body mass indexes. Nutrition, 25, 25–32.
10.1016/j.nut.2008.07.004
PubMed Web of Science® Google Scholar
Shishikura, K., Tanimoto, K., Sakai, S., Tanimoto, Y., Terasaki, J., & Hanafusa, T. (2014). Association between skeletal muscle mass and insulin secretion in patients with type 2 diabetes mellitus. Endocrine Journal, 61, 281–287.
10.1507/endocrj.EJ13-0375
CAS PubMed Web of Science® Google Scholar
Tanaka, H., Monahan, K. D., & Seals, D. R. (2001). Age-predicted maximal heart rate revisited. Journal of the American College of Cardiology, 37, 153–156.
10.1016/S0735-1097(00)01054-8
CAS PubMed Web of Science® Google Scholar
van, H. K., Mortelmans, P., & Lefevre, J. (2014). Validation of the SenseWear Pro3 Armband using an incremental exercise test. Journal of Strength and Conditioning Research, 28, 2806–2814.
10.1519/JSC.0b013e3182a1f836
PubMed Web of Science® Google Scholar
Villarini, A., Pasanisi, P., Traina, A., Mano, M. P., Bonanni, B., Panico, S., … & Berrino, F. (2012). Lifestyle and breast cancer recurrences: The DIANA-5 trial. Tumori, 98, 1–18.
10.1177/030089161209800101
CAS PubMed Web of Science® Google Scholar
Villasenor, A., Ballard-Barbash, R., Baumgartner, K., Baumgartner, R., Bernstein, L., McTiernan, A., & Neuhouser, M. L. (2012). Prevalence and prognostic effect of sarcopenia in breast cancer survivors: The HEAL Study. Journal of Cancer Survivorship, 6, 398–406.
10.1007/s11764-012-0234-x
PubMed Web of Science® Google Scholar
World Cancer Research Fund. (2014). Diet, nutrition, physical acivity and breast cancer survivors. Available from: http://www.wcrf.org/sites/default/files/Breast-Cancer-Survivors-2014-Report.pdf. [last accessed 25 August 2016]
Google Scholar
World Cancer Research Fund & American Institute for Cancer Research. (2007). Food, nutrition, physical activity and the prevention of cancer: A global perspective. Washington, DC: AICR.
Google Scholar
Wu, Y., Zhang, D., & Kang, S. (2013). Physical activity and risk of breast cancer: A meta-analysis of prospective studies. Breast Cancer Research and Treatment, 137, 869–882.
10.1007/s10549-012-2396-7
PubMed Web of Science® Google Scholar
Zhong, S., Jiang, T., Ma, T., Zhang, X., Tang, J., Chen, W., Lv, M., & Zhao, J. (2014). Association between physical activity and mortality in breast cancer: A meta-analysis of cohort studies. European Journal of Epidemiology, 29, 391–404.
10.1007/s10654-014-9916-1
PubMed Web of Science® Google Scholar

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