Cutaneous nodular fasciitis with genetic analysis: a case series
Correction(s) for this article
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Corrigendum
- Volume 44Issue 5Journal of Cutaneous Pathology
- pages: 512-512
- First Published online: April 6, 2017
Erica Kumar
Department of Pathology, Regional Medical Laboratory, Tulsa, OK, USA
Search for more papers by this authorNimesh R. Patel
Department of Pathology and Laboratory Medicine, Rhode Island Hospital, Brown University, Providence, USA
Search for more papers by this authorElizabeth G. Demicco
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, New York, NY, USA
Search for more papers by this authorJudith V.M.G. Bovee
Leiden University Medical Center, Leiden, the Netherlands
Search for more papers by this authorAndre M. Olivera
Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN, USA
Search for more papers by this authorDolores H. Lopez-Terrada
Department of Pathology, Immunology and Pediatrics, Texas Children's Hospital/Baylor College of Medicine, Houston, TX, USA
Search for more papers by this authorSteven D. Billings
Department of Pathology, Cleveland Clinic Hospitals, Cleveland, OH, USA
Search for more papers by this authorAlexander J. Lazar
Department of Pathology and Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Search for more papers by this authorCorresponding Author
Wei-Lien Wang
Department of Pathology and Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Wei-Lien Wang, MD,
Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 085, Houston, TX 77030, USA
Tel: +713 792 4240
fax: +713 745 8228
e-mail: [email protected]
Search for more papers by this authorErica Kumar
Department of Pathology, Regional Medical Laboratory, Tulsa, OK, USA
Search for more papers by this authorNimesh R. Patel
Department of Pathology and Laboratory Medicine, Rhode Island Hospital, Brown University, Providence, USA
Search for more papers by this authorElizabeth G. Demicco
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, New York, NY, USA
Search for more papers by this authorJudith V.M.G. Bovee
Leiden University Medical Center, Leiden, the Netherlands
Search for more papers by this authorAndre M. Olivera
Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN, USA
Search for more papers by this authorDolores H. Lopez-Terrada
Department of Pathology, Immunology and Pediatrics, Texas Children's Hospital/Baylor College of Medicine, Houston, TX, USA
Search for more papers by this authorSteven D. Billings
Department of Pathology, Cleveland Clinic Hospitals, Cleveland, OH, USA
Search for more papers by this authorAlexander J. Lazar
Department of Pathology and Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Search for more papers by this authorCorresponding Author
Wei-Lien Wang
Department of Pathology and Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Wei-Lien Wang, MD,
Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 085, Houston, TX 77030, USA
Tel: +713 792 4240
fax: +713 745 8228
e-mail: [email protected]
Search for more papers by this authorAbstract
Nodular fasciitis is a benign self-limited myofibroblastic neoplasm, which usually involves the upper extremities and trunk of young patients. These tumors have been shown to harbor a translocation involving the MYH9 and USP6 genes, leading to overexpression of the latter. We report seven cases of nodular fasciitis with cutaneous presentations. All cases involved the dermis, with six involving the superficial subcutis, and one auricular tumor extending into cartilage. All cases showed USP6 rearrangement by fluorescence in situ hybridization; in two of three cases, the characteristic MYH9-USP6 fusion was shown by RT-PCR. All patients underwent conservative resection. Nodular fasciitis is an uncommon mesenchymal neoplasm that can occasionally present in superficial locations and is sometimes mistaken for a malignant process. Molecular testing can be useful to distinguish this entity from other cutaneous spindle cell tumors.
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