The histopathologic spectrum of decorative tattoo complications
Corresponding Author
Michi M. Shinohara
Department of Medicine, Division of Dermatology, University of Washington, Seattle, WA, USA
Michi M Shinohara, MD
Division of Dermatology, Department of Medicine
University of Washington
Box 356524
Seattle, Washington DC 98195, USA
Tel: +1 206 543 5290
Fax: +1 206 543 2489
e-mail: [email protected]
Search for more papers by this authorJennifer Nguyen
Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA
Search for more papers by this authorJennifer Gardner
Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA
Search for more papers by this authorMisha Rosenbach
Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA
Search for more papers by this authorRosalie Elenitsas
Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA
Search for more papers by this authorCorresponding Author
Michi M. Shinohara
Department of Medicine, Division of Dermatology, University of Washington, Seattle, WA, USA
Michi M Shinohara, MD
Division of Dermatology, Department of Medicine
University of Washington
Box 356524
Seattle, Washington DC 98195, USA
Tel: +1 206 543 5290
Fax: +1 206 543 2489
e-mail: [email protected]
Search for more papers by this authorJennifer Nguyen
Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA
Search for more papers by this authorJennifer Gardner
Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA
Search for more papers by this authorMisha Rosenbach
Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA
Search for more papers by this authorRosalie Elenitsas
Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA
Search for more papers by this authorAbstract
Tattooing for ornamental purposes is an ancient practice that remains popular in modern times. Tattoos are encountered by the dermatopathologist either as incidental findings on skin biopsies or because of complications specific to the tattoo. A range of neoplasms and inflammatory conditions are seen in association with tattoos, many of which may be attributed to hypersensitivity to tattoo inks. The composition of tattoo inks is highly variable, and inks can contain numerous potentially allergenic or carcinogenic compounds. Infections with bacterial, viral and fungal species can occur after tattooing, sometimes after substantial delay. Atypical mycobacterial infections in particular are increasingly reported; special stains for mycobacteria should be performed and cultures recommended particularly when dense, mixed or granulomatous infiltrates are present.
References
- 1Sperry K. Tattoos and tattooing. Part I: history and methodology. Am J Forensic Med Pathol 1991; 12: 313.
- 2Armstrong ML, Murphy KP. Tattooing: another adolescent risk behavior warranting health education. Appl Nurs Res 1997; 10: 181.
- 3Laumann AE, Derik AJ. Tattoos and body piercings in the United States: a national data set. J Am Acad Dermatol 2006; 55: 413.
- 4Kazandjieva J, Tsankov N. Tattoos: dermatological complications. Clin Dermatol 2007; 25: 375.
- 5Forte G, Petrucci F, Cristaudo A, Bocca B. Market survey on toxic metals contained in tattoo inks. Sci Total Environ 2009; 407: 5997.
- 6Engel E, Santarelli F, Vasold R, et al. Modern tattoos cause high concentrations of hazardous pigments in skin. Contact Dermatitis 2008; 58: 228.
- 7Engel E, Vasold R, Santarelli F, et al. Tattooing of skin results in transportation and light-induced decomposition of tattoo pigments – a first quantification in vivo using a mouse model. Exp Dermatol 2009; 19: 54.
- 8Sperry K. Tattoos and tattooing. Part II: gross pathology, histopathology, medical complications, and applications. Am J Forensic Med Pathol 1992; 13: 7.
- 9Granstein RD, Sober AJ. Drug- and heavy metal-induced hyperpigmentation. J Am Acad Dermatol 1981; 5: 1.
- 10McGrae JD Jr, Zelickson AS. Skin pigmentation secondary to minocycline therapy. Arch Dermatol 1980; 116: 1262.
- 11Puri PK, Lountzis NI, Tyler W, Ferringer T. Hydroxychloroquine-induced hyperpigmentation: the staining pattern. J Cutan Pathol 2008; 35: 1134.
- 12Ammoury A, Michaud S, Paul C, et al. Photodistribution of blue-gray hyperpigmentation after amiodarone treatment: molecular characterization of amiodarone in the skin. Arch Dermatol 2008; 144: 92.
- 13http://www.fda.gov[accessed on 12 February 2012]
- 14Timko AL, Miller CH, Johnson FB, Ross EV. In vitro quantitative chemical analysis of tattoo pigments. Arch Dermatol 2001; 137: 143.
- 15Lehner K, Santarelli F, Vasold R, König B, Landthaler M, Bäumler W. Black tattoo inks are a source of problematic substances such as dibutyl phthalate. Contact Dermatitis 2011; 65: 231.
- 16Cui Y, Spann AP, Couch LH, et al. Photodecomposition of pigment yellow 74, a pigment used in tattoo inks. Photochem Photobiol 2004; 80: 175.
- 17Hogsberg T, Loeschner K, Lof D, Serup J. Tattoo inks of general usage contain nanoparticles. Br J Dermatol 2011 Epub ahead of print. DOI: 10.1111/j.1365-2133.2011.10561.x.
- 18Birnie AJ, Kulkarni K, Varma S. Basal cell carcinoma arising in a tattoo. Clin Exp Dermatol 2006; 31: 820.
- 19Sarma DP, Dentlinger RB, Forystek AM, Stevens T, Huerter C. Poorly differentiated squamous cell carcinoma arising in tattooed skin. Case Report Med 2010; 2010: 431813 Epub 13 January 2011.
- 20West CC, Morritt AN, Pedelty L, Lam DG. Cutaneous leiomyosarcoma arising in a tattoo – 'a tumour with no humour'. J Plast Reconstr Aesthet Surg 2009; 62: e79.
- 21Kluger N, Minier-Thoumin C, Plantier F. Keratoacanthoma occurring within the red dye of a tattoo. J Cutan Pathol 2008; 35: 504.
- 22Koh MJA, Teo RYL, Liu TT. Multiple epidermal cysts occurring in a tattoo. Singapore Med J 2009; 50: e376.
- 23Regensburger J, Lehner K, Maisch T, et al. Tattoo inks contain polycyclic aromatic hydrocarbons that additionally generate deleterious singlet oxygen. Exp Dermatol 2010; 19: e275.
- 24Kirsch N. Malignant melanoma developing in a tattoo. Arch Dermatol 1969; 99: 596.
- 25Paradisi A, Capizzi R, De Simone C, Fossati B, Proietti I, Amerio PL. Malignant melanoma in a tattoo: case report and review of the literature. Melanoma Res 2006; 16: 375.
- 26Persechino S, Caperchi C, Bartolazzi A. Melanoma mimicry on a tattoo: an autograft hypothesis. J Am Acad Dermatol 2007; 57: S122.
- 27Singh RS, Hafeez Diwan A, Prieto VG. Potential diagnostic pitfalls in melanoma arising in a cutaneous tattoo. Histopathology 2007; 51: 283.
- 28Dominguez E, Alegre V, Garcia-Melgares ML, et al. Tattoo pigment in two lymph nodes in a patient with melanoma. J Eur Acad Dermatol Venereol 2008; 22: 101.
- 29Bordea C, Latifaj B, Jaffe W. Delayed presentation of tattoo lymphadenopathy mimicking malignant melanoma lymphadenopathy. J Plast Reconstr Aesthet Surg 2009; 62: e282.
10.1016/j.bjps.2007.11.039 Google Scholar
- 30Horner KL, Chien AJ, Edenholm M, Hornung RL. Winnie the Pooh and psoriasis too: an isomorphic response of guttate psoriasis in a tattoo. Pediatr Dermatol 2007; 24: E70.
- 31Kluger N. Cutaneous complications related to permanent decorative tattooing. Expert Rev Clin Immunol 2010; 6: 363.
- 32Corraza M, Zampino MR, Montanari A, Pagnoni A, Virgili A. Lichenoid reaction from a permanent red tattoo: has nickel a possible aetiologic role? Contact Dermatitis 2002; 46: 114.
- 33Wenzel SM, Welzel J, Hafner C, Landthaler M, Bäumler W. Permanent make-up colorants may cause severe skin reactions. Contact Dermatitis 2010; 63: 223.
- 34La Placa M, Passarini B. Subacute cutaneous lupus erythematosus after a tattoo. Clin Exp Dermatol 2009; 34: 632.
- 35Winkelmann RK, Harris RB. Lichenoid delayed hypersensitivity reactions in tattoos. J Cutan Pathol 1979; 6: 59.
- 36Mortimer NJ, Chave T, Johnstone GA. Red tattoo reactions. Clin Exp Dermatol 2003; 28: 508.
- 37Litak J, Ke MS, Gutierrez MA, Soriano T, Lask GP. Generalized lichenoid reaction from tattoo. Dermatol Surg 2007; 33: 736.
- 38Dang M, Hsu S, Bernstein E. Lichen planus or lichenoid tattoo reaction? Int J Dermatol 1998; 37: 860.
- 39Ramos-Casals M, Mana J, Nardi N, et al. Sarcoidosis in patients with chronic hepatitis C virus infection. Medicine 2005; 84: 69.
- 40Hurst EA, Mauro T. Sarcoidosis associated with pegylated interferon alfa and ribavirin treatment for chronic hepatitis C. Arch Dermatol 2005; 141: 865.
- 41Perera GK, Calonje E. Systemic sarcoidosis presenting in a tattooed man undergoing treatment for hepatitis C. Clin Exp Dermatol 2006; 31: 387.
- 42Bagwan IN, Walker M, Theaker JM. Granuloma annulare-like tattoo reaction. J Cutan Pathol 2007; 34: 804.
- 43Bethune GC, Miller RA, Murray SJ, Walsh NM. A novel inflammatory reaction in a tattoo: challenge. Am J Dermatopathol 2011; 33: 740.
- 44Bethune GC, Miller RA, Murray SJ, et al. A novel inflammatory reaction in a tattoo: answer. Am J Dermatopathol 2011; 33: 749.
10.1097/DAD.0b013e318225372c Google Scholar
- 45Shin JB, Seo SH, Kim BK, Kim IH, Son SW. Cutaneous T cell pseudolymphoma at the site of a semipermanent lip-liner tattoo. Dermatology 2009; 218: 75.
- 46Kahofer P, El Shabrawi-Caelen L, Horn M, Kern T, Smolle J. Pseudolymphoma occurring in a tattoo. Eur J Dermatol 2003; 13: 209.
- 47Sangueza OP, Yadav S, White CR Jr, Braziel RM. Evolution of B-cell lymphoma from pseudolymphoma. A multidisciplinary approach using histology, immunohistochemistry, and Southern blot analysis. Am J Dermatopathol 1992; 14: 408.
- 48Patrizi A, Raone B, Savoia F, et al. Tattoo-associated pseudolymphomatous reaction and its successful treatment with hydroxychloroquine. Acta Derm Venereol 2009; 89: 327.
- 49Mahalingam M, Kim E, Bhawan J. Morphea-like tattoo reaction. Am J Dermatopathol 2002; 24: 392.
- 50Kluger N, Mathelier-Fusade P, Moguelet P. Scleroderma-like reaction restricted to the red parts of a tattoo. Acta Derm Venereol 2009; 89: 95.
- 51Bechara C, Macheras E, Heym B, Pages A, Auffret N. Mycobacterium abscessus skin infection after tattooing: first case report and review of the literature. Dermatology 2010; 221: 1.
- 52Wong HW, Tay YK, Sim CS. Papular eruption on a tattoo: a case of primary inoculation tuberculosis. Australas J Dermatol 2005; 46: 84.
- 53Ghorpade A. Tattoo inoculation lupus vulgaris in two Indian ladies. J Eur Acad Dermatol Venereol 2006; 20: 476.
- 54Ghorpade A. Inoculation (tattoo) leprosy: a report of 31 cases. J Eur Acad Dermatol Venereol 2002; 16: 494.
- 55Trefzer U, Schmollack KP, Stockfleth E, Sterry W, Kolde G. Verrucae in a multicolored decorative tattoo. J Am Acad Dermatol 2004; 50: 478.
- 56Brajac I, Loncarek K, Stoinic-Sosa L, Gruber F. Delayed onset of warts over a tattoo mark provoked by sunburn. J Eur Acad Dermatol Venereol 2005; 19: 247.
- 57Parker C, Kaminski G, Hill D. Zygomycosis in a tattoo, caused by Saksenaea vasiformis. Australas J Dermatol 1986; 87: 107.
10.1111/j.1440-0960.1986.tb00304.x Google Scholar
- 58Centers for Disease Control and Prevention (CDC). Tattoo-associated nontuberculous mycobacterial skin infections–multiple states, 2011–2012. MMWR Morb Mortal Wkly Rep 2012; 61: 653.