A quantification of regenerated bone tissue in human sinus biopsies: influences of anatomical region, age and sex
Karoline Maria Reich
Karl Donath Laboratory for Hard Tissue and Biomaterial Research, Department of Oral Surgery, Medical University of Vienna, Vienna, Austria
Austrian Cluster for Tissue Regeneration, Vienna, Austria
Search for more papers by this authorChristian Domitian Huber
Karl Donath Laboratory for Hard Tissue and Biomaterial Research, Department of Oral Surgery, Medical University of Vienna, Vienna, Austria
Austrian Cluster for Tissue Regeneration, Vienna, Austria
Search for more papers by this authorPatrick Heimel
Karl Donath Laboratory for Hard Tissue and Biomaterial Research, Department of Oral Surgery, Medical University of Vienna, Vienna, Austria
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the Trauma Research Center of AUVA, Vienna, Austria
Search for more papers by this authorChristian Ulm
Department of Oral Surgery, Medical University of Vienna, Vienna, Austria
Search for more papers by this authorHeinz Redl
Austrian Cluster for Tissue Regeneration, Vienna, Austria
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the Trauma Research Center of AUVA, Vienna, Austria
Search for more papers by this authorCorresponding Author
Stefan Tangl
Karl Donath Laboratory for Hard Tissue and Biomaterial Research, Department of Oral Surgery, Medical University of Vienna, Vienna, Austria
Austrian Cluster for Tissue Regeneration, Vienna, Austria
Corresponding author:
Stefan Tangl
Karl Donath Laboratory for Hard Tissue and Biomaterial Research, Department of Oral Surgery
Medical University of Vienna
Sensengasse 2a, 1090 Vienna
Austria
Tel.: +43 1 40070/2628
Fax: +43 1 40070/4109
e-mail: [email protected]
Search for more papers by this authorKaroline Maria Reich
Karl Donath Laboratory for Hard Tissue and Biomaterial Research, Department of Oral Surgery, Medical University of Vienna, Vienna, Austria
Austrian Cluster for Tissue Regeneration, Vienna, Austria
Search for more papers by this authorChristian Domitian Huber
Karl Donath Laboratory for Hard Tissue and Biomaterial Research, Department of Oral Surgery, Medical University of Vienna, Vienna, Austria
Austrian Cluster for Tissue Regeneration, Vienna, Austria
Search for more papers by this authorPatrick Heimel
Karl Donath Laboratory for Hard Tissue and Biomaterial Research, Department of Oral Surgery, Medical University of Vienna, Vienna, Austria
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the Trauma Research Center of AUVA, Vienna, Austria
Search for more papers by this authorChristian Ulm
Department of Oral Surgery, Medical University of Vienna, Vienna, Austria
Search for more papers by this authorHeinz Redl
Austrian Cluster for Tissue Regeneration, Vienna, Austria
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the Trauma Research Center of AUVA, Vienna, Austria
Search for more papers by this authorCorresponding Author
Stefan Tangl
Karl Donath Laboratory for Hard Tissue and Biomaterial Research, Department of Oral Surgery, Medical University of Vienna, Vienna, Austria
Austrian Cluster for Tissue Regeneration, Vienna, Austria
Corresponding author:
Stefan Tangl
Karl Donath Laboratory for Hard Tissue and Biomaterial Research, Department of Oral Surgery
Medical University of Vienna
Sensengasse 2a, 1090 Vienna
Austria
Tel.: +43 1 40070/2628
Fax: +43 1 40070/4109
e-mail: [email protected]
Search for more papers by this authorAbstract
Objectives
Sinus augmentation is a standard procedure to increase vertical bone supply for dental implants in the atrophic posterior maxilla. Despite the longstanding application of this method, information about some basic factors that could potentially influence bone regeneration after sinus augmentation is rare. The objective of this study was therefore to quantify the impact of the maxillary region (premolar/molar) and patients' age and sex on bone regeneration after sinus grafting.
Material and methods
Sinus augmentation procedures were performed in 107 patients (66 female: 52.8 ± 11.0 years, 41 male: 50.6 ± 11.3 years). After 6 ± 1 months, 201 sinus biopsies were harvested and histomorphometrically analysed. Height (oldHt) and bone volume fraction of pristine bone (oldBV/TV), as well as the amount of new bone (newBV/TV) and bone-to-bone substitute contact (BBSC) in the augmentation area, were assessed.
Results
In women, newBV/TV in the augmented sinus decreased significantly by 0.22 ± 0.08% per year. In men, no similar trend was observed. There were strong influences of the maxillary region and the dimensions of the host bone. In the premolar region, newBV/TV was 23.1 ± 7.9% and 25.1 ± 10.1%; in the molar region, newBV/TV averaged 20.4 ± 9.4% and 17.8 ± 8.8% for women and men, respectively. The greater the thickness of the wall of the sinus floor (mainly in the former premolar region), the greater was the amount of new bone tissue formed in the spaces in-between bone substitute particles.
Conclusions
These empirical results derived from a large human sample, link factors that influence the quality of biomaterial integration to the known clinical risks for the success of dental implants.
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