Pre-augmentation soft tissue expansion: an overview
Farah Asa'ad
Department of Biomedical, Surgical and Dental Sciences, Foundation IRCCS Ca' Granda Polyclinic, University of Milan, Milan, Italy
Search for more papers by this authorCorresponding Author
Giulio Rasperini
Department of Biomedical, Surgical and Dental Sciences, Foundation IRCCS Ca' Granda Polyclinic, University of Milan, Milan, Italy
Corresponding author:
Giulio Rasperini
Dental Clinic, University of Milan, Via della Commenda, 10, I-20122 Milan, Italy
Tel.: + +39 02 5032 0244
Fax: +39 0523 335523
e-mail: [email protected]
Search for more papers by this authorGiorgio Pagni
Department of Biomedical, Surgical and Dental Sciences, Foundation IRCCS Ca' Granda Polyclinic, University of Milan, Milan, Italy
Search for more papers by this authorHector F. Rios
Department of Periodontics and Oral Medicine, Michigan Center for Oral Health Research, University of Michigan School of Dentistry, Ann Arbor, MI, USA
Search for more papers by this authorAldo B. Giannì
Department of Biomedical, Surgical and Dental Sciences, Foundation IRCCS Ca' Granda Polyclinic, University of Milan, Milan, Italy
Search for more papers by this authorFarah Asa'ad
Department of Biomedical, Surgical and Dental Sciences, Foundation IRCCS Ca' Granda Polyclinic, University of Milan, Milan, Italy
Search for more papers by this authorCorresponding Author
Giulio Rasperini
Department of Biomedical, Surgical and Dental Sciences, Foundation IRCCS Ca' Granda Polyclinic, University of Milan, Milan, Italy
Corresponding author:
Giulio Rasperini
Dental Clinic, University of Milan, Via della Commenda, 10, I-20122 Milan, Italy
Tel.: + +39 02 5032 0244
Fax: +39 0523 335523
e-mail: [email protected]
Search for more papers by this authorGiorgio Pagni
Department of Biomedical, Surgical and Dental Sciences, Foundation IRCCS Ca' Granda Polyclinic, University of Milan, Milan, Italy
Search for more papers by this authorHector F. Rios
Department of Periodontics and Oral Medicine, Michigan Center for Oral Health Research, University of Michigan School of Dentistry, Ann Arbor, MI, USA
Search for more papers by this authorAldo B. Giannì
Department of Biomedical, Surgical and Dental Sciences, Foundation IRCCS Ca' Granda Polyclinic, University of Milan, Milan, Italy
Search for more papers by this authorAbstract
Objectives
The aim of this study was to explore the development of soft tissue expanders, their different types and their potential applications prior to bone augmentation and implant placement.
Material and Methods
A review of pertinent literature was performed using PubMed to comprehend the dynamics of soft tissue expanders and determine the current position of their pre-augmentation applications.
Results
There is promising, albeit preliminary information regarding the benefits of pre-augmentation soft tissue expansion. Findings cannot be generalised due to relatively small sample size.
Conclusions
Further clinical trials with larger sample sizes and long-term follow-up are needed before soft tissue expanders can be confidently applied in everyday clinical practice.
References
- Abrahamsson, P., Isaksson, S. & Andersson, G. (2011) Guided bone generation in a rabbit mandible model after periosteal expansion with an osmotic tissue expander. Clinical Oral Implants Research 22: 1282–1288.
- Abrahamsson, P., Isaksson, S., Gordh, M. & Andersson, G. (2009) Periosteal expansion of rabbit mandible with an osmotic self-inflatable expander. Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery 43: 121–125.
- Abrahamsson, P., Isaksson, S., Gordh, M. & Andersson, G. (2010) Onlay bone grafting of the mandible after periosteal expansion with an osmotic tissue expander: an experimental study in rabbits. Clinical Oral Implants Research 21: 1404–1410.
- Abrahamsson, P., Wälivaara, D.Å., Isaksson, S. & Andersson, G. (2012) Periosteal expansion before local bone reconstruction using a new technique for measuring soft tissue profile stability: a clinical study. Journal of Oral and Maxillofacial Surgery 70: e521–e530.
- Adler, N., Dorafshar, A.H., Bauer, B.S., Hoadley, S. & Tournell, M. (2009) Tissue expander infections in pediatric patients: management and outcomes. Plastic Reconstructive Surgery 124: 484–489.
- Allen, M.R., Hock, J.M. & Burr, D.B. (2004) Periosteum: biology, regulation, and response to osteoporosis therapies. Bone 35: 1003–1012.
- Antonyshyn, O., Gruss, J.S., Mackinnon, S.E. & Zuker, R. (1988a) Complications of soft tissue expansion. British Journal of Plastic Surgery 41: 239–250.
- Antonyshyn, O., Gruss, J.S., Zuker, R. & MacKinnon, S.E. (1988b) Tissue expansion in head and neck reconstruction. Plastic and Reconstructive Surgery 82: 58–68.
- Anwander, T., Schneider, M., Gloger, W., Reich, R.H., Appel, T., Martini, M., Wenghoefer, M., Merkx, M. & Berge, S. (2007) Investigation of the expansion properties of osmotic expanders with and without silicone shell in animals. Plastic and Reconstructive Surgery 120: 590–595.
- Argenta, L.C., Marks, M.W. & Grabb, W.C. (1983) Selective use of serial expansion in breast reconstruction. Annals of Plastic Surgery 11: 188–195.
- Argenta, L.C., Marks, M.W. & Pasyk, K.A. (1985) Advances in tissue expansion. Clinical Plastic Surgery 12: 159–171.
- Argenta, L.C. & VanderKolk, C.A. (1987) Tissue expansion in craniofacial surgery. Clinical Plastic Surgery 14: 143–153.
- Ashman, A. (2000) Ridge preservation: important buzzwords in dentistry. General Dentistry 48: 304–312.
- Austad, E.D., Pasyk, K.A., Mc Clatchey, K.D. & Cherry, G.W. (1982) Histomorphologic evaluation of guinea pig skin and soft tissue after controlled tissue expansion. Plastic Reconstructive Surgery 70: 704–710.
- Austad, E.D. & Rose, G.L. (1982) A self-inflating tissue expander. Plastic and Reconstructive Surgery 70: 588–594.
- Bahat, O. & Handelsman, M. (1991) Controlled tissue expansion in reconstructive periodontal surgery. The International Journal of Periodontics & Restorative Dentistry 11: 32–47.
- Bascom, D.A. & Wax, K.A. (2002) Tissue expansion in the head and neck: current state of the art. Current Opinion in Otolaryngology & Head and Neck Surgery 10: 273–277.
10.1097/00020840-200208000-00005 Google Scholar
- Belghith, A., Jeblaoui, Y., Njah, H., Zairi, I., Zitouni, K. & Adouani, A. (2012) Complications of head and neck skin expansion. Revue de Stomatologie et de Chirurgie Maxillo-faciale 113: 411–414. [Article in French]
- Bell, C.L. & Peppas, N.A. (1996) Water, solute and protein diffusion in physiologically responsive hydrogels of poly(methacrylic acid-g-ethylene glycol). Biomaterials 17: 1203–1218.
- Bell, R.B., Blakey, G.H., White, R.P., Hillebrand, D.G. & Molina, A. (2002) Staged reconstruc-tion of the severely atrophic mandible with autogenous bone graft and endosteal implants. Journal of Oral & Maxillofacial Surgery 60: 1135–1141.
- Bennett, R.G. & Hirt, M. (1993) A history of tissue expansion: concepts, controversies, and complications. The Journal of Dermatologic Surgery and Oncology 19: 1066–1073.
- Berge, S.J., Wiese, K.G., von Lindern, J.J., Niederhagen, B., Appel, T. & Reich, R.H. (2001) Tissue expansion using osmotically active hydrogel systems for direct closure of the donor defect of the radial forearm flap. Plastic and Reconstructive Surgery 108: 1–5, discussion 6–7.
- Brobmann, G.F. & Huber, J. (1985) Effects of different shaped tissue expanders on transluminal pressure, oxygen tension, histopathologic changes, and skin expansion in pigs. Plastic and Reconstructive Surgery 76: 731–736.
- Burkhardt, R. & Lang, N.P. (2010) Role of flap tension in primary wound closure of mucoperiosteal flaps: a prospective cohort study. Clinical Oral Implants Research 21: 50–54.
- Caffesse, R.G., Castelli, W.A. & Nasjleti, C.E. (1981) Vascular response to modified widman flap surgery in monkeys. Journal of Periodontology 52: 1–7.
- Carlsson, G.E. (2004) Responses of jawbone to pressure. Gerodontology 21: 65–70.
- Chanavaz, M. (1995) Anatomy and histophysiology of the periosteum: quantification of the periosteal blood supply to the adjacent bone with 85Sr and gamma spectrometry. Journal of Oral Implantology 21: 214–219.
- Chiapasco, M., Romeo, E., Casentini, P. & Rimondini, L. (2004) Alveolar distraction osteogenesis vs. vertical guided bone regeneration for the correction of vertically deficient edentulous ridges: a 1–3-year prospective study on humans. Clinical Oral Implants Research 15: 82–95.
- Chiapasco, M., Romeo, E., Coggiola, A. & Brusati, R. (2011) Long-term outcome of dental implants placed in revascularized fibula free flaps used for the reconstruction of maxillo-mandibular defects due to extreme atrophy. Clinical Oral Implants Research 22: 83–91.
- Chiapasco, M., Zaniboni, M. & Boisco, M. (2006) Augmentation procedures for the rehabilitation of deficient edentulous ridges with oral implants. Clinical Oral Implants Research 17: 136–159.
- Chummun, S., Addison, P. & Stewart, K.J. (2010) The osmotic tissue expander: a 5-year experience. Journal of Plastic, Reconstructive & Aesthetic Surgery 63: 2128–2132.
- Copeland, L.B., Krall, E.A., Brown, L.J., Garcia, R.I. & Streckfus, C.F. (2004) Predictors of tooth loss in two US adult populations. Journal of Public Health Dentistry 64: 31–37.
- Cordaro, L., Amadé, D.S. & Cordaro, M. (2002) Clinical results of alveolar ridge augmentation with mandibular block bone grafts in partially edentulous patients prior to implant placement. Clinical Oral Implants Research 13: 103–111.
- De Agustin, J.C., Morris, S.F. & Zuker, R.M. (1993) Tissue expansion in pediatric burn reconstruction. Journal of Burn Care & rehabilitation 14: 43–50.
- De Santis, G., Nocini, P.F., Chiarini, L. & Bedogni, A. (2004) Functional rehabilitation of the atrophic mandible and maxilla with fibula flaps and implant-supported prosthesis. Plastic and Reconstructive Surgery 113: 88–98, discussion 99-100.
- Degidi, M., Scarano, A. & Piattelli, A. (2003) Regeneration of the alveolar crest using titanium micromesh with autologous bone and a resorbable membrane. Journal of Oral Implantology 29: 86–90.
- Downes, R., Lavin, M. & Collin, R. (1992) Hydrophilic expanders for the congenital anophthalmic socket. Advances in Ophthalmic Plastic and Reconstructive Surgery 9: 57–61.
- Edington, H.D., Mooney, M.P., Losken, A., Hurwitz, D.J. & Siegel, M.I. (1998) The effects of soft-tissue expansion on lip repair and midfacial growth in a rabbit cleft lip model. Annals of Plastic Surgery 41: 171–179.
- Eke, P.I., Dye, B.A., Wei, L., Thornton-Evans, G.O. & Genco, R.J., CDC Periodontal Disease Surveillance workgroup: James Beck (University of North Carolina, Chapel Hill, USA), Gordon Douglass (Past President, American Academy of Periodontology), Roy Page (University of Washington) (2012) Prevalence of periodontitis in adults in the United States: 2009 and 2010. Journal of Dental Research 91: 914–920.
- El-Saadi, M.M. & Nasr, M.A. (2008) The effect of tissue expansion on skull bones in the paediatric age group from 2 to 7 years. Journal of Plastic, Reconstructive & Aesthetic Surgery 61: 413–418.
- Esposito, M., Cannizarro, G., Soardi, E., Pellegrino, G., Pistilli, R. & Felice, P. (2011) A 3-year post-loading report of a randomised controlled trial on the rehabilitation of posterior atrophic mandibles: short implants or longer implants in vertically augmented bone? European Journal of Oral Implantology 4: 301–311.
- Esposito, M., Grusovin, M.G., Felice, P., Karatzo- poulos, G., Worthington, H.V. & Coulthard, P. (2009) Interventions for replacing missing teeth: horizontal and vertical bone augmentation techniques for dental implant treatment. Cochrane Database of Systematic Reviews 7: CD003607.
- Esposito, M., Grusovin, M.G., Maghaireh, H., Coulthard, P. & Worthington, H.V. (2007) Interventions for replacing missing teeth: management of soft tissues for dental implants. Cochrane Database of Systematic Reviews 3: CD006697.
- Fang, L., Zhou, C. & Yang, M. (2013) “Expansion in-situ” concept as a new technique for expanding skin and soft tissue. Experimental and Therapeutic Medicine 6: 1295–1299.
- Formby, P., Flint, J., Gordon, W.T., Fleming, M. & Andersen, R.C. (2013) Use of a continuous external tissue expander in the conversion of a type IIIB fracture to a type IIIA fracture. Orthopedics 36: e249–e251.
- Friedman, R.M., Ingram, A.E., Rohrich, R.J., Byrd, H.S., Hodges, P.L., Burns, A.J. & Hobar, P.C. (1996) Risk factors for complications in pediatric tissue expansion. Plastic and Reconstructive Surgery 98: 1242–1246.
- Fudem, G.M. & Orgel, M.G. (1988) Full-thickness erosion of the skull secondary to tissue expansion for scalp reconstruction. Plastic and Reconstructive Surgery 82: 368–369.
- Gibstein, L.A., Abramson, D.L., Bartlett, R.A., Orgill, D.P., Upton, J. & Mulliken, J.B. (1997) Tissue expansion in children: a retrospective study of complications. Annals of Plastic Surgery 38: 358–364.
- Greenstein, G., Greenstein, B., Cavallaro, J., Elian, N. & Tarnow, D. (2009) Flap advancement: practical techniques to attain tension-free primary closure. Journal of Periodontology 80: 4–15.
- Hemmer, K.M., Marsh, J.L. & Picker, S. (1987) Calvarial erosion after scalp expansion. Annals of Plastic Surgery 19: 454–459.
- Huo, R., Yang, W., Shangbin, L., Tingting L, Yang.Z., Feng, G., Qinping, Y. & Wehao, Z. (2009) A microscopic and biomechanical study of skin and soft tissue after repeated expansion. Dermatologic Surgery 35: 72–79.
- Hurvitz, K.A., Rosen, H. & Meara, J.G. (2005) Pediatric cervicofacial tissue expansion. International Journal of Pediatric Otorhinolaryngology 69: 1509–1513.
- Iconomou, T.G., Michelow, B.J. & Zuker, R.M. (1993) Tissue expansion in the pediatric patient. Annals of Plastic Surgery 31: 134–140.
- Jenkins, W.M., MacFarlane, T.W. & Gilmour, W.H. (1988) Longitudinal study of untreated periodontitis (I). Clinical findings. Journal of Clinical Periodontology 15: 324–330.
- Jensen, S.S. & Terheyden, H. (2009) Bone augmentation procedures in localized defects in the alveolar ridge: clinical results with different bone grafts and bone-substitute materials. International Journal of Oral & Maxillofacial Implants 24: 218–236.
- Jivraj, S. & Chee, W. (2006) Treatment planning of implants in the aesthetic zone. British Dental Journal 201: 77–89.
- Johnson, T.M., Lowe, L., Brown, M.D., Sullivan, M.J. & Nelson, B.R. (1993) Histology and physiology of tissue expansion. The Journal of Dermatologic Surgery and Oncology 12: 1074–1078.
10.1111/j.1524-4725.1993.tb01002.x Google Scholar
- Jung, G.U., Pang, E.K. & Park, C.J. (2014) Anterior maxillary defect reconstruction with a staged bilateral rotated palatal graft. Journal of Periodontal and Implant Science 44: 147–155.
- Kaner, D. & Friedmann, A. (2011) Soft tissue expansion with self-filling osmotic tissue expanders before vertical ridge augmentation: a proof of principle study. Journal of Clinical Periodontology 38: 95–101.
- Kaner, D., Zhao, H., Terheyden, H. & Friedmann, A. (2014) Submucosal implantation of soft tissue expanders does not affect microcirculation. Clinical Oral Implants Research 25: 867–870.
- Kaner, D., Zhao, H., Terheyden, H. & Friedmann, A. (2015) Improvement of microcirculation and wound healing in vertical ridge augmentation after pre-treatment with self-inflating soft tissue expanders - a randomized study in dogs. Clinical Oral Implants Research 26: 720–724.
- Kessler, P., Bumiller, L., Schlegel, A., Birkholz, T., Neukam, F.W. & Wiltfang, J. (2007) Dynamic periosteal elevation. British Journal of Oral and Maxillofacial Surgery 45: 284–287.
- Kobus, K.F. (2007) Cleft palate repair with the use of osmotic expanders: a preliminary report. Journal of Plastic, Reconstructive and Aesthetic Surgery 60: 414–421.
- Kowalski, M.J., Schemitsch, E.H., Kregor, P.J., Senft, D. & Swiontkowski, M.F. (1996) Effect of periosteal stripping on cortical bone perfusion: a laser Doppler study in sheep. Calcified Tissue International 59: 24–26.
- LaTrenta, G.S., McCarthy, J.G., Epstein, M., Cutting, C.B. & Orentreich, C. (1988) Bone graft survival in expanded skin. Plastic and Reconstructive Surgery 81: 406–413.
- Lew, D., Amos, E.L. & Shroyer, J.V. III (1988) The use of a sub-periosteal tissue expander in rib reconstruction of an atrophic mandible. Journal of Oral & Maxillofacial Surgery 46: 229–232.
- Lew, D., Hinkle, R.M. & Collins, S.F. (1991) Use of subperiosteal implants with distal filling ports in the correction of the atrophic alveolar ridge. International Journal of Oral and Maxillofacial Surgery 20: 15–17.
- Lindfors, L.T., Tervonen, E.A., Sándor, G.K. & Ylikontiola, L.P. (2010) Guided bone regeneration using a titanium-reinforced ePTFE membrane and particulate autogenous bone: the effect of smoking and membrane exposure. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology 109: 825–830.
- Liu, J. & Kerns, D.G. (2014) Mechanisms of guided bone regeneration: a review. The Open Dentistry Journal 8: 56–65.
- Liu, Y., Zang, M., Song, B., Zhu, S., Jin, J., Yu, S., Xu, L., Liu, D. & Ding, Q. (2011) The ‘buddy flap’ concept of soft-tissue-defect reconstruction. Journal of Plastic, Reconstructive & Aesthetic Surgery 64: 1475–1482.
- Lundgren, S., Sjostrom, M., Nystrom, E. & Sennerby, L. (2008) Strategies in reconstruction of the atrophic maxilla with autogenous bone grafts and endosseous implants. Periodontology 2000(47): 143–161.
- Manders, E.K., Schenden, M.J., Furrey, J.A., Hetzler, P.T., Davis, T.S. & Graham, W.P. III (1984) Soft-tissue expansion: concepts and complications. Plastic and Reconstructive Surgery 74: 493–507.
- Mason, A.C., Davison, S.P. & Manders, E.K. (1999) Tissue expander infections in children: look beyond the expander pocket. Annals of Plastic Surgery 43: 539–541.
- Mazzoli, R.A., Raymond, W.R., 4th, Ainbinder, D.J. & Hansen, E.A. (2004) Use of self-expanding, hydrophilic osmotic expanders (hydrogel) in the reconstruction of congenital clinical anophthalmos. Current Opinion in Ophthalmology 15: 426–431.
- McAllister, B.S. & Haghighat, K. (2007) Bone augmentation techniques. Journal of Periodontology 78: 377–396.
- Merli, M., Migani, M. & Esposito, M. (2007) Vertical ridge augmentation with autogenous bone grafts: resorbable barriers supported by ostheosynthesis plates versus titanium-reinforced barriers. A preliminary report of a blinded, randomized controlled clinical trial. The International Journal of Oral & Maxillofacial Implants 22: 373–382.
- Mertens, C., Thiele, O., Engel, M., Seeberger, R., Hoffmann, J. & Freier, K. (2015) The use of selfinflating soft tissue expanders prior to bone augmentation of atrophied alveolar ridges. Clinical Implant Dentistry and Related Research 17: 44–51.
- Moghadam, H.G. (2009) Vertical and horizontal bone augmentation with the intraoral autogenous J-graft. Implant Dentistry 18: 230–238.
- Mormann, W. & Ciancio, S.G. (1977) Blood supply of human gingiva following periodontal surgery. A fluorescein angiographic study. Journal of Periodontology 48: 681–692.
- Nakayama, Y., Soeda, S. & Kasai, Y. (1982) The importance of arterial inflow in the distal side of a flap: an experimental investigation. Plastic and Reconstructive Surgery 69: 61–67.
- Neale, H.W., High, R.M., Billmire, D.A., Carey, J.P., Smith, D. & Warden, G. (1998) Complications of controlled tissue expansion in the pediatric burn patient. Plastic and Reconstructive Surgery 82: 840–848.
- Neumann, C.G. (1957) The expansion of an area of skin by progressive distention of a subcutaneous balloon; use of the method for securing skin for subtotal reconstruction of the ear. Plastic and Reconstructive Surgery 19: 124–130.
- Nobuto, T., Suwa, F., Kono, T., Hatakeyama, Y., Honjou, N., Shirai, T., Mitsuyama, M. & Imai, H. (2005) Microvascular response in the periosteum following mucoperiosteal flap surgery in dogs: 3-dimensional observation of an angiogenic pro- cess. Journal of Periodontology 76: 1339–1345.
- Nyström, E., Nilson, H., Gunne, J. & Lundgren, S. (2009) A 9–14 year follow-up of onlay bone grafting in the atrophic maxilla. International Journal of Oral and Maxillofacial Surgery 38: 111–116.
- Obdeijn, M.C., Nicolai, J.P. & Werker, P.M. (2009) The osmotic tissue expander: a three-year clinical experience. Journal of Plastic, Reconstructive & Aesthetic Surgery 9: 1219–1222.
- Oda, T., Kinoshita, K. & Ueda, M. (2009) Effects of cortical bone perforation on periosteal distraction: an experimental study in the rabbit mandible. Journal of Oral and Maxillofacial Surgery 67: 1478–1485.
- Paletta, C.E., Bass, J. & Shehadi, S.I. (1989) Outer table skull erosion causing rupture of scalp expander. Annals of Plastic Surgery 23: 538–542.
- Park, S.H., Choi, S.K., Jang, J.H., Kim, J.W., Kim, J.Y., Kim, M.R. & Kim, S.J. (2013) Self-inflating oral tissue expander for ridge augmentation in the severely atrophic mandible. Journal of the Korean Association of Oral and Maxillofacial Surgeons 39: 31–34.
- Pasyk, K.A., Argenta, L.C. & Hassett, C. (1988) Quantitative analysis of the thickness of human skin and subcutaneous tissue following controlled expansion with a silicone implant. Plastic and Reconstructive Surgery 81: 516–523.
- Pasyk, K.A., Austad, E.D. & Cherry, G.W. (1984) Intracellular collagen fibers in the capsule around silicone expanders in guinea pigs. The Journal of Surgical Research 36: 125–133.
- Pasyk, K.A., Austad, E.D., McClatchey, K.D. & Cherry, G.W. (1982) Electron microscopic evaluation of guinea pig skin and soft tissues expanded with a self-inflating silicone implant. Plastic and Reconstructive Surgery 70: 37–45.
- Penoff, J. (1990) Skin expansion—A sword that “stretches” two ways: scalp expansion and bone erosion. Journal of Craniofacial Surgery 1: 103–105.
- Pietila, J.P. (1990) Tissue expansion and skin circulation. Simultaneous monitoring by laser Doppler flowmetry and transcutaneous oximetry. Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery 24: 135–140.
- Pisarski, G.P., Mertens, D., Warden, G.D. & Neale, H.W. (1998) Tissue expander complications in the pediatric burn patient. Plastic and Reconstructive Surgery 102: 1008–1012.
- Proussaefs, P. & Lozada, J. (2005) The use of intraorally harvested autogenous block grafts for vertical alveolar ridge augmentation: a human study. International Journal of Periodontics and Restorative Dentistry 25: 351–363.
- Radovan, C. (1982) Breast reconstruction after mastectomy using the temporary expander. Plastic and Reconstructive Surgery 69: 195–208.
- Radovan, C. (1984) Tissue expansion in soft-tissue reconstruction. Plastic and Reconstructive Surgery 74: 482–492.
- Rees, L., Morris, P. & Hall, P. (2008) Osmotic tissue expanders in cleft lip and palate surgery: a cautionary tale. Journal of Plastic, Reconstructive and Aesthetic Surgery 61: 119–120.
- Refojo, M.F. (1975) Vapour-pressure and swelling pressure of hydrogels. Abstracts of Papers of the American Chemical Society 170: 71.
- Rocchietta, I., Fontana, F. & Simion, M. (2008) Clinical outcomes of vertical bone augmentation to enable dental implant placement: a systematic review. Journal of Clinical Periodontology 35: 203–215.
- Roccuzzo, M., Ramieri, G., Bunino, M. & Berrone, S. (2007) Autogenous bone graft alone or associated with titanium mesh for vertical alveolar ridge augmentation: a controlled clinical trial. Clinical Oral Implants Research 18: 286–294.
- Rohner, D., Bucher, P., Kunz, C., Hammer, B., Schenk, R.K. & Prein, J. (2002) Treatment of severe atrophy of the maxilla with the prefabricated free vascularized fibula flap. Clinical Oral Implants Research; 13: 44–52.
- Ronert, M.A., Hofheinz, H., Manassa, E., Asgarouladi, H. & Olbrisch, R.R. (2004) The beginning of a new era in tissue expansion: self filling osmotic tissue expander- four year clinical experience. Plastic and Reconstructive Surgery 114: 1025–1031.
- Roposch, A., Steinwender, G. & Linhart, W.E. (1999) Implantation of a soft-tissue expander before operation for club foot in children. Journal of Bone and Joint Surgery, British Volume 81: 398–401.
- Rothamel, D., Schwarz, F., Herten, M., Ferrari, D., Mischkowski, R.A., Sager, M. & Becker, J. (2009) Vertical ridge augmentation using xenogenous bone blocks: a histomorphometric study in dogs. The International Journal of Oral & Maxillofacial Implants 24: 243–250.
- Rucker, M., Binger, T., Deltcheva, K. & Menger, M.D. (2005) Reduction of midfacial periosteal perfusion failure by subperiosteal versus supraperiosteal dissection. Journal of Oral and Maxillofacial Surgery 63: 87–92.
- Sato, T., Hara, T., Mori, S., Shirai, H. & Minagi, S. (1998) Threshold for bone resorption induced by continuous and intermittent pressure in the rat hard palate. Journal of Dental Research 77: 387–392.
- Schmelzeisen, R., Schimming, R., Schwipper, V. & Heydecke, G. (1999) Influence of tissue expanders on the growing craniofacial skeleton. Journal of Cranio-Maxillofacial Surgery 27: 153–159.
- Schmidt, B.L., Kung, L., Jones, C. & Casap, N. (2002) Induced osteogenesis by periosteal distraction. Journal of Oral and Maxillofacial Surgery 60: 1170–1175.
- Schnittkowski, M.H.V., Knaape, A., Gundlach, K., Fichter, N. & Guthoff, R. (2003) Therapie des kongenitalen klinischen Anophthalmus mit hoch hydrophilen hydrogelexpandern. Der Ophthalmologe 7: 524–535.
- Schönmeyr, B., Clavin, N., Avraham, T., Longo, V. & Mehrara, B.J. (2009) Synthesis of a tissue- engineered periosteum with acellular dermal matrix and cultured mesenchymal stem cells. Tissue Engineering Part A 15: 1833–1841.
- Schwartz, H.C. & Relle, R.J. (1990) Extraoral placement of a subperiosteal tissue expander for reconstruction with hydroxylapatite of the severely atrophic mandibular alveolar ridge. Journal of Oral and Maxillofacial Surgery 48: 157–161.
- Schropp, L., Wenzel, A., Kostopoulos, L. & Karring, T. (2003) Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study. International Journal of Periodontics and Restorative Dentistry 23: 313–323.
- Sencimen, M., Aydintug, Y.S., Ortakoglu, K., Karslioglu, Y., Gunhan, O. & Gunaydin, Y. (2007) Histomorphometrical analysis of new bone obtained by distraction osteogenesis and osteogenesis by periosteal distraction in rabbits. International Journal of Oral and Maxillofacial Surgery 36: 235–242.
- Sinow, J.D., Halvorsen, R.A. Jr, Matts, J.P., Schubert, W., Letourneau, J.G. & Cunningham, B.L. (1991) Chest wall deformity after tissue expansion for breast reconstruction. Plastic and Reconstructive Surgery 88: 998–1004.
- Sonick, M. & Hwang, D. (2007) Tooth extraction—an opportunity for site preservation. Contemporary Aesthetics 11: 36–41.
- Stuehmer, C., Rucker, M., Schumann, P., Bormann, K.H., Harder, Y., Sinikovic, B. & Gellrich, N.C. (2009) Osseous alterations at the interface of hydrogel expanders and underlying bone. Journal of Cranio-Maxillo-Facial Surgery 37: 258–262.
- Swan, M.C., Goodacre, T.E., Czernuszka, J.T. & Bucknall, D.G. (2008) Cleft palate repair with the use of osmotic expanders: a response. Journal of Plastic, Reconstructive & Aesthetic Surgery 61: 220–221.
- Swan, M.C., Bucknall, D.G., Czernuszka, J.T., Pigott, D.W. & Goodacre, T.E. (2012) Development of a novel anisotropic self-inflating tissue expander: in vivo submucoperiosteal performance in the porcine hard palate. Plastic and Reconstructive Surgery 129: 79–88.
- Swan, M.C., Bucknall, D.G., Goodacre, T.E. & Czernuszka, J.T. (2011) Synthesis and properties of a novel anisotropic self-inflating hydrogel tissue expander. Acta Biomaterialia 7: 1126–1132.
- Svindland, A.D., Nordsletten, L., Reikeras, O. & Skjeldal, S. (1995) Periosteal response to transient ischemia: histological studies on the rat tibia. Acta Orthopaedica Scandinavica 66: 468–472.
- Tominaga, K., Matsuo, T., Kuga, Y. & Mizuno, A. (1993) An animal model for subperiosteal tissue expansion. Journal of Oral & Maxillofacial Surgery 51: 1244–1249.
- Tudor, C., Bumiller, L., Birkholz, T., Stockmann, P., Wiltfang, J. & Kessler, P. (2010) Static and dynamic periosteal elevation: a pilot study in a pig model. International Journal of Oral and Maxillofacial Surgery 39: 897–903.
- Uckan, S., Dolanmaz, D., Kalayci, A. & Cilasun, U. (2002) Distraction osteogenesis of basal mandibular bone for reconstruction of the alveolar ridge. British Journal of Oral and Maxillofacial Surgery 40: 393–396.
- Uijlenbroek, H.J., Liu, Y., He, J.F., Visscher, C., van Waas, M.A. & Wismeyer, D. (2011) Expanding soft tissue with Osmed tissue expanders in the goat maxilla. Clinical Oral Implants Research 22: 121–128.
- van Damme, P.A., Freihofer, H.P., Maltha, J.C., Kuijpers-Jagtman, A.M. & van't Hof, M.A. (1997) Three-dimensional morphometric analysis of the effects of subperiosteal palatal soft-tissue expansion in growing cats. International Journal of Oral and Maxillofacial Surgery 26: 61–67.
- van Damme, P.A., Freihofer, H.P., van't Hof, M.A., Kuijpers-Jagtman, A.M., Maltha, J.C. & Spijkers, J.M. (1994) Radiologic analysis of the effects of subperiosteal palatal soft-tissue expansion in growing cats. International Journal of Oral and Maxillofacial Surgery 23: 393–394.
- van Damme, P.A., Heidbuchel, K.L., Kuijpers-Jagtman, A.M., Maltha, J.C. & Freihofer, H.P. (1992) Cranio-maxillo-facial tissue expansion, experimentally based or clinically empiric? A review of the literature. Journal of Cranio-Maxillo-Facial Surgery 20: 61–69.
- van Rappard, J.H., Molenaar, J., van Doorn, K., Sonneveld, G.J. & Borghouts, J.M. (1988) Surface-area increase in tissue expansion. Plastic and Reconstructive Surgery 82: 833–839.
- Varga, J., Janovak, L., Varga, E., Eros, G., Dekany, I. & Kemeny, L. (2009) Acrylamide, acrylic acid and N-isopropylacrylamide hydrogels as osmotic tissue expanders. Skin Pharmacology and Physiology 22: 305–312.
- Verhoeven, J.W., Cune, M.S., Terlou, M., Zoon, M.A. & de Putter, C. (1997) The combined use of endosteal implants and iliac crest onlay grafts in the severely atrophic mandible: a longitudinal study. The International Journal of Oral & Maxillofacial Surgery 26: 351–357.
- von See, C., Rücker, M., Bormann, K.H. & Gellrich, N.C. (2010a) Using a novel self-inflating hydrogel expander for intraoral gingival tissue expansion prior to bone augmentation. British Journal of Oral and Maxillofacial Surgery 48: e5–e6.
- von See, C., Rücker, M., Schumann, P., Goetz, F., Wefstaedt, P., Nolte, I., von der Hoeh, N., Meyer-Lindenberg, A., Tavassol, F. & Gellrich, N.C. (2010b) Micro-computed tomography and histologic evaluation of the interface of hydrogel expander and underlying bone: influence of pressure distributors on bone resorption. Journal of Oral and Maxillofacial Surgery 68: 2179–2184.
- von See, C., Gellrich, N.C., Bormann, K.H., Rahmann, A. & Rücker, M. (2010c) Microvascular response to the subperiosteal implantation of self-inflating hydrogel expanders. The International Journal of Oral and Maxillofacial Implants 25: 979–984.
- von See, C., Gellrich, N.C., Jachmann, U., Laschke, M.W., Bormann, K.H. & Rücker, M. (2010d) Bone augmentation after soft-tissue expansion using hydrogel expanders: effects on microcirculation and osseointegration. Clinical Oral Implants Research 21: 842–847.
- Wacke, R., Drewelow, B., Mundkowski, R.G., Guthoff, R.F. & Schittkowski, M.P. (2011) In vitro kinetics of delivery of tobramycin and ofloxacin from osmotic hydro gel expanders. International Journal of Clinical Pharmacology and Therapeutics 49: 422–427.
- Wälivaara, D.A., Isaksson, S. & Rosén, S. (2007) Description of a technique for evaluation of three-dimensional shape alterations in soft tissue after intra oral bone reconstruction. British Journal of Oral and Maxillofacial Surgery 45: 382–386.
- Wang, H.L. & Boyapati, L. (2006a) “PASS” principles for predictable bone regeneration. Implant Dentistry 15: 8–17.
- Wang, H.L. & Boyapati, L. (2006b) “PASS” principles for predictable bone regeneration. Implant Dentistry 15: 8–17.
- Warnke, P.H., Douglas, T., Sivananthan, S., Wiltfang, J., Springer, I. & Becker, S.T. (2009) Tissue engineering of periosteal cell membranes in vitro. Clinical Oral Implants Research 20: 761–766.
- Wee, S.S., Logan, S. & Mustoe, T.A. (1992) Continuous versus intraoperative expansion in the pig model. Plastic and Reconstructive Surgery 90: 808–814.
- Wiese, K.G. (1993) Osmotically induced tissue expansion with hydrogels: a new dimension in tissue expansion? A preliminary report. Journal of Cranio-Maxillo-Facial Surgery 21: 309–313.
- Wiese, K.G., Heinemann, D.E., Ostermeier, D. & Peters, J.H. (2001) Biomaterial properties and biocompatibility in cell culture of a novel self-inflating hydrogel tissue expander. Journal of Biomedical Materials Research 54: 179–188.
- Wiese, K.G., Vogel, M., Guthoff, R. & Gundlach, K.K. (1999) Treatment of congenital anophthalmos with self-inflating polymer expanders: a new method. Journal of Cranio-Maxillo-Facial Surgery 27: 72–76.
- Wieslander, J.B. (1991) Tissue expansion in the head and neck. A 6-year review. Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery 25: 47–56.
- Wittkampf, A.R. (1989) Short-term experience with the subperiosteal tissue expander in reconstruction of the mandibular alveolar ridge. Journal of Oral & Maxillofacial Surgery 47: 469–474.
- Xie, C., Reynolds, D., Awad, H., Rubery, P.T., Pelled, G., Gazit, D., Guldberg, R.E., Schwarz, E.M., O'Keefe, R.J. & Zhang, X. (2007) Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering. Tissue Engineering 13: 435–445.
- Zeiter, D.J., Ries, W.L., Weir, T.L., Mishkin, D.J. & Sanders, J.J. (1998) The use of a soft tissue expander in an alveolar bone ridge augmentation for implant placement. International Journal of Periodontics and Restorative Dentistry 18: 403–409.
- Zerbo, I.R., de Lange, G.L., Joldersma, M., Bronckers, A.L. & Burger, E.H. (2003) Fate of monocortical bone blocks grafted in the human maxilla: a histological and histomorphometric study. Clinical Oral Implants Research 14: 759–766.
- Zhang, X., Awad, H.A., O'Keefe, R.J., Guldberg, R.E. & Schwarz, E.M. (2008) A perspective: engineering periosteum for structural bone graft healing. Clinical Orthopaedics and Related Research 466: 1777–1787.