Moderate endurance exercise in patients with sickle cell anaemia: effects on oxidative stress and endothelial activation
Camille Faes
CRIS EA647, Université de Lyon 1, Villeurbanne, France
Search for more papers by this authorEdwige Balayssac-Siransy
Laboratoire de physiologie et d'explorations fonctionnelles, Unité de Formation et de Recherche en Sciences Médicales, Université Felix Houphouët Boigny, Abidjan, Ivory Coast, France
Service des explorations fonctionnelles et endoscopiques, Centre hospitalier universitaire de Yopougon, Abidjan, Ivory Coast, France
Search for more papers by this authorPhilippe Connes
UMR Inserm U665, Université des Antilles et de la Guyanne, Pointe à Pitre, Guadeloupe, France
Laboratory of Excellence GR-Ex “The RedCell: from genesis to death”, PRES Sorbonne, Paris Cité, France
Laboratoire ACTES (EA3596), Département de physiologie, Université des Antilles et de la Guyanne, Pointe à Pitre, Guadeloupe, France
Search for more papers by this authorLudovic Hivert
CRIS EA647, Université de Lyon 1, Villeurbanne, France
Search for more papers by this authorClotaire Danho
Service des explorations fonctionnelles et endoscopiques, Centre hospitalier universitaire de Yopougon, Abidjan, Ivory Coast, France
Search for more papers by this authorPascal Bogui
Laboratoire de physiologie et d'explorations fonctionnelles, Unité de Formation et de Recherche en Sciences Médicales, Université Felix Houphouët Boigny, Abidjan, Ivory Coast, France
Service des explorations fonctionnelles et endoscopiques, Centre hospitalier universitaire de Yopougon, Abidjan, Ivory Coast, France
Search for more papers by this authorCorresponding Author
Cyril Martin
CRIS EA647, Université de Lyon 1, Villeurbanne, France
Equivalent place.Correspondence: Cyril Martin, Université Claude Bernard Lyon 1, Centre de Recherche et d'Innovation sur le Sport, Campus de la Doua, 69622 Villeurbanne Cedex, France.
E-mail: [email protected]
Search for more papers by this authorVincent Pialoux
CRIS EA647, Université de Lyon 1, Villeurbanne, France
Equivalent place.Search for more papers by this authorCamille Faes
CRIS EA647, Université de Lyon 1, Villeurbanne, France
Search for more papers by this authorEdwige Balayssac-Siransy
Laboratoire de physiologie et d'explorations fonctionnelles, Unité de Formation et de Recherche en Sciences Médicales, Université Felix Houphouët Boigny, Abidjan, Ivory Coast, France
Service des explorations fonctionnelles et endoscopiques, Centre hospitalier universitaire de Yopougon, Abidjan, Ivory Coast, France
Search for more papers by this authorPhilippe Connes
UMR Inserm U665, Université des Antilles et de la Guyanne, Pointe à Pitre, Guadeloupe, France
Laboratory of Excellence GR-Ex “The RedCell: from genesis to death”, PRES Sorbonne, Paris Cité, France
Laboratoire ACTES (EA3596), Département de physiologie, Université des Antilles et de la Guyanne, Pointe à Pitre, Guadeloupe, France
Search for more papers by this authorLudovic Hivert
CRIS EA647, Université de Lyon 1, Villeurbanne, France
Search for more papers by this authorClotaire Danho
Service des explorations fonctionnelles et endoscopiques, Centre hospitalier universitaire de Yopougon, Abidjan, Ivory Coast, France
Search for more papers by this authorPascal Bogui
Laboratoire de physiologie et d'explorations fonctionnelles, Unité de Formation et de Recherche en Sciences Médicales, Université Felix Houphouët Boigny, Abidjan, Ivory Coast, France
Service des explorations fonctionnelles et endoscopiques, Centre hospitalier universitaire de Yopougon, Abidjan, Ivory Coast, France
Search for more papers by this authorCorresponding Author
Cyril Martin
CRIS EA647, Université de Lyon 1, Villeurbanne, France
Equivalent place.Correspondence: Cyril Martin, Université Claude Bernard Lyon 1, Centre de Recherche et d'Innovation sur le Sport, Campus de la Doua, 69622 Villeurbanne Cedex, France.
E-mail: [email protected]
Search for more papers by this authorVincent Pialoux
CRIS EA647, Université de Lyon 1, Villeurbanne, France
Equivalent place.Search for more papers by this authorSummary
Very few studies have investigated the effects of exercise on the biological parameters involved in vaso-occlusive events in sickle cell anaemia (SCA). The aim of this study was to test how a mild-moderate endurance exercise modulates oxidative stress, nitric oxide bioavailability and endothelial activation in SCA patients and healthy individuals. Eleven patients with SCA and 15 healthy subjects completed a 20-min duration submaximal cycling exercise at ≈45 Watts. Plasma markers of oxidative stress, antioxidant activity, endothelial activation and nitric oxide bioavailability were investigated before and after the exercise. Nitric oxide levels, anti-oxidant capacity, soluble (s)E-selectin and sP-selectin did not change in response to this exercise. Except for the malondialdehyde levels, which increased in the two groups, the other markers of oxidative stress remained unchanged in both groups in response to exercise. Soluble vascular cell adhesion molecule 1 levels were increased at the end of exercise in both groups. sL-selectin decreased and soluble intercellular adhesion molecule 1 increased with exercise in SCA patients only. The present data suggest that patients with SCA may undertake mild-moderate physical activities without any acute clinical complications, but care should be taken because oxidative stress and endothelial activation significantly increased in some patients.
Supporting Information
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| bjh12594-sup-0001-DataS1.docxWord document, 28.5 KB | Data S1. Methods. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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