Prognostic impact of monocyte count at presentation in mantle cell lymphoma
Kathrin Aprile von Hohenstaufen
IOSI – Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
These authors contributed equally to the manuscript.Search for more papers by this authorAnnarita Conconi
Division of Haematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont and Azienda Ospedaliero-Universitaria Maggiore della Carità, Novara, Italy
These authors contributed equally to the manuscript.Search for more papers by this authorCassio Polpo de Campos
Dalle Molle Institute for Artificial Intelligence, Manno-Lugano, Switzerland
Lymphoma & Genomics Research Program, IOR Institute of Oncology Research, Bellinzona, Switzerland
Search for more papers by this authorSilvia Franceschetti
Division of Haematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont and Azienda Ospedaliero-Universitaria Maggiore della Carità, Novara, Italy
Search for more papers by this authorFrancesco Bertoni
IOSI – Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
Lymphoma & Genomics Research Program, IOR Institute of Oncology Research, Bellinzona, Switzerland
Search for more papers by this authorGloria Margiotta Casaluci
Division of Haematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont and Azienda Ospedaliero-Universitaria Maggiore della Carità, Novara, Italy
Search for more papers by this authorAnastasios Stathis
IOSI – Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
Search for more papers by this authorMichele Ghielmini
IOSI – Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
Search for more papers by this authorGeorg Stussi
IOSI – Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
Search for more papers by this authorFranco Cavalli
IOSI – Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
Search for more papers by this authorGianluca Gaidano
Division of Haematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont and Azienda Ospedaliero-Universitaria Maggiore della Carità, Novara, Italy
Co-senior authors.Search for more papers by this authorCorresponding Author
Emanuele Zucca
IOSI – Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
Co-senior authors.Correspondence: Dr. Emanuele Zucca, IOSI – Oncology Institute of Southern Switzerland, Ospedale San Giovanni, CH-6500 Bellinzona, Switzerland.
E-mail: [email protected]
Search for more papers by this authorKathrin Aprile von Hohenstaufen
IOSI – Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
These authors contributed equally to the manuscript.Search for more papers by this authorAnnarita Conconi
Division of Haematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont and Azienda Ospedaliero-Universitaria Maggiore della Carità, Novara, Italy
These authors contributed equally to the manuscript.Search for more papers by this authorCassio Polpo de Campos
Dalle Molle Institute for Artificial Intelligence, Manno-Lugano, Switzerland
Lymphoma & Genomics Research Program, IOR Institute of Oncology Research, Bellinzona, Switzerland
Search for more papers by this authorSilvia Franceschetti
Division of Haematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont and Azienda Ospedaliero-Universitaria Maggiore della Carità, Novara, Italy
Search for more papers by this authorFrancesco Bertoni
IOSI – Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
Lymphoma & Genomics Research Program, IOR Institute of Oncology Research, Bellinzona, Switzerland
Search for more papers by this authorGloria Margiotta Casaluci
Division of Haematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont and Azienda Ospedaliero-Universitaria Maggiore della Carità, Novara, Italy
Search for more papers by this authorAnastasios Stathis
IOSI – Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
Search for more papers by this authorMichele Ghielmini
IOSI – Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
Search for more papers by this authorGeorg Stussi
IOSI – Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
Search for more papers by this authorFranco Cavalli
IOSI – Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
Search for more papers by this authorGianluca Gaidano
Division of Haematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont and Azienda Ospedaliero-Universitaria Maggiore della Carità, Novara, Italy
Co-senior authors.Search for more papers by this authorCorresponding Author
Emanuele Zucca
IOSI – Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
Co-senior authors.Correspondence: Dr. Emanuele Zucca, IOSI – Oncology Institute of Southern Switzerland, Ospedale San Giovanni, CH-6500 Bellinzona, Switzerland.
E-mail: [email protected]
Search for more papers by this authorSummary
An increased number of circulating monocytes at presentation has recently been associated with shorter survival in Hodgkin lymphoma, follicular lymphoma and diffuse large B cell lymphoma. This study aimed to assess the prognostic impact of the absolute monocyte count (AMC) at diagnosis in mantle cell lymphoma (MCL). AMC at diagnosis was available in 97 MCL cases recorded in the databases of the Oncology Institute of Southern Switzerland in Bellinzona (Switzerland) and the Division of Haematology of the Amedeo Avogadro University of Eastern Piedmont in Novara (Italy). With a median follow up of 7 years, the 5-year overall survival was 29% for patients with AMC >0·50 × 109/l and 62% for patients with AMC ≤0·50 × 109/l (P = 0·008). Elevated AMC and beta-2 microglobulin at diagnosis remained independent outcome predictors at multivariate analysis, controlling for the MCL International Prognostic Index (MIPI), and have been used to build a simple prognostic scoring system. In this relatively small and heterogeneous series an increased AMC identified poor-risk patients. Our results suggest that AMC together with the beta-2 microglobulin level might provide an inexpensive way to stratify MCL patient risk as a complement to the MIPI, which was confirmed to be a very powerful prognostic tool.
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