Volume 175, Issue 6 pp. 1175-1182

Epidemiology

Risk of skin cancer in patients on chronic haemodialysis: a nationwide, population-based study in Taiwan^†

C.-C. Wang,

C.-C. Wang

Department of Dermatology, Cardinal Tien Hospital, New Taipei City, Taiwan

School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan

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C.-H. Tang,

C.-H. Tang

School of Health Care Administration, College of Management, Taipei Medical University, Taipei, Taiwan

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C.-Y. Wang,

C.-Y. Wang

School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan

Department of Internal Medicine and Medical Research Center, Cardinal Tien Hospital, New Taipei City, Taiwan

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S.-Y. Huang,

S.-Y. Huang

School of Health Care Administration, College of Management, Taipei Medical University, Taipei, Taiwan

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Y.-M. Sue,

Corresponding Author

Y.-M. Sue

[email protected]

Division of Nephrology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan

Division of Nephrology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

Correspondence

Yuh-Mou Sue.

E-mail: [email protected]

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C.-C. Wang,

C.-C. Wang

Department of Dermatology, Cardinal Tien Hospital, New Taipei City, Taiwan

School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan

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C.-H. Tang,

C.-H. Tang

School of Health Care Administration, College of Management, Taipei Medical University, Taipei, Taiwan

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C.-Y. Wang,

C.-Y. Wang

School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan

Department of Internal Medicine and Medical Research Center, Cardinal Tien Hospital, New Taipei City, Taiwan

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S.-Y. Huang,

S.-Y. Huang

School of Health Care Administration, College of Management, Taipei Medical University, Taipei, Taiwan

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Y.-M. Sue,

Corresponding Author

Y.-M. Sue

[email protected]

Division of Nephrology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan

Division of Nephrology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

Correspondence

Yuh-Mou Sue.

E-mail: [email protected]

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First published: 07 June 2016

https://doi.org/10.1111/bjd.14789

Citations: 16

^†

Funding sources This work was financially supported by research grants provided by Cardinal Tien Hospital, New Taipei City, Taiwan (grant CTH-104-1-2A09) and Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan (grants 100-wf-eva-15 and 101-wf-eva-03).

^‡

Conflicts of interest None declared.

^§

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Summary

Background

Patients on chronic haemodialysis (HD) have a higher incidence of cancer. However, the risk of skin cancer in this population has rarely been investigated.

Objectives

To investigate the risk of nonmelanoma skin cancer (NMSC) and cutaneous melanoma in patients on chronic HD and to explore the associated risk factors.

Methods

We performed retrospective cohort and nested case–control studies using records in the Taiwanese National Health Insurance Research Database between 1999 and 2013. The HD cohort included 79 668 incident patients on HD, for whom the standardized incidence ratios (SIRs) for incident NMSC and cutaneous melanoma were determined. In the nested case–control study, patients on HD with NMSC were matched to those without skin cancers. The impact of various factors on the development of NMSC was determined by conditional logistic regression analysis.

Results

Among the 79 668 patients on HD, 248 cases of NMSC and 22 cases of cutaneous melanoma occurred after a mean 4·95 years of follow-up. The SIRs for NMSC and cutaneous melanoma in patients on HD were 1·58 (95% confidence interval 1·39–1·79) and 1·44 (95% confidence interval 0·91–2·19), respectively. Of the patients on HD, a higher risk of NMSC was found in men (1·5-fold), South Taiwan residents (twofold) and patients with uraemic pruritus after long-term antihistamine treatment (1·53-fold). However, the incidence of NMSC was not increased in patients with uraemic pruritus receiving ultraviolet B phototherapy.

Conclusions

Patients on chronic HD are at higher risk of NMSC. Uraemic pruritus further increases the risk of NMSC, which might be prevented by ultraviolet B phototherapy.

Supporting Information

References

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Citing Literature

Volume175, Issue6

December 2016

Pages 1175-1182

Risk of skin cancer in patients on chronic haemodialysis: a nationwide, population-based study in Taiwan^†

Summary

Background

Objectives

Methods

Results

Conclusions

Supporting Information

References

Citing Literature

References

Information

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Risk of skin cancer in patients on chronic haemodialysis: a nationwide, population-based study in Taiwan†

Summary

Background

Objectives

Methods

Results

Conclusions

Supporting Information

References

Citing Literature

References

Related

Information

Risk of skin cancer in patients on chronic haemodialysis: a nationwide, population-based study in Taiwan^†