Dermatopathology

Secondary cutaneous lymphoma: comparative clinical features and survival outcome analysis of 106 cases according to lymphoma cell lineage

W.J. Lee

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnapdong Songpagu, Seoul, 138-736 Korea

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K.H. Won,

K.H. Won

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnapdong Songpagu, Seoul, 138-736 Korea

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C.H. Won,

C.H. Won

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnapdong Songpagu, Seoul, 138-736 Korea

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S.E. Chang,

S.E. Chang

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnapdong Songpagu, Seoul, 138-736 Korea

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J.H. Choi,

J.H. Choi

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnapdong Songpagu, Seoul, 138-736 Korea

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K.C. Moon,

K.C. Moon

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnapdong Songpagu, Seoul, 138-736 Korea

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C.-S. Park,

C.-S. Park

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnapdong Songpagu, Seoul, 138-736 Korea

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J. Huh,

J. Huh

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnapdong Songpagu, Seoul, 138-736 Korea

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C. Suh,

C. Suh

Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnapdong Songpagu, Seoul, 138-736 Korea

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M.W. Lee,

Corresponding Author

M.W. Lee

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnapdong Songpagu, Seoul, 138-736 Korea

Correspondence

Mi Woo Lee.

E-mail: [email protected]

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W.J. Lee,

W.J. Lee

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnapdong Songpagu, Seoul, 138-736 Korea

Search for more papers by this author

K.H. Won,

K.H. Won

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnapdong Songpagu, Seoul, 138-736 Korea

Search for more papers by this author

C.H. Won,

C.H. Won

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnapdong Songpagu, Seoul, 138-736 Korea

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S.E. Chang,

S.E. Chang

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnapdong Songpagu, Seoul, 138-736 Korea

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J.H. Choi,

J.H. Choi

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnapdong Songpagu, Seoul, 138-736 Korea

Search for more papers by this author

K.C. Moon,

K.C. Moon

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnapdong Songpagu, Seoul, 138-736 Korea

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C.-S. Park,

C.-S. Park

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnapdong Songpagu, Seoul, 138-736 Korea

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J. Huh,

J. Huh

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnapdong Songpagu, Seoul, 138-736 Korea

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C. Suh,

C. Suh

Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnapdong Songpagu, Seoul, 138-736 Korea

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M.W. Lee,

Corresponding Author

M.W. Lee

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnapdong Songpagu, Seoul, 138-736 Korea

Correspondence

Mi Woo Lee.

E-mail: [email protected]

Search for more papers by this author

First published: 31 December 2014

https://doi.org/10.1111/bjd.13582

Citations: 21

Funding sources:

No external funding.

Conflicts of interest:

None declared.

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Summary

Background

The relative frequency, clinical features and survival outcomes of secondary cutaneous lymphoma remain poorly understood.

Objectives

To determine the clinical characteristics and survival outcomes of secondary cutaneous lymphoma.

Materials and methods

The present retrospective cohort study included all 106 patients who presented with secondary cutaneous lymphoma. Patient medical records were reviewed to determine the clinical features, survival outcomes and prognostic factors. Survival outcomes were analysed by using the Kaplan–Meier method and comparisons between lymphoma cell lineages [T or natural killer (T-/NK)-cell vs. B-cell lymphoma] were performed using the log-rank test.

Results

Secondary cutaneous lymphomas consisted of mature T-/NK-cell lymphomas (56%), mature B-cell lymphomas (35%), immature haematopoietic malignancies (8%) and Hodgkin lymphoma (1%). The T-/NK-cell lineage lymphoma cases were more likely to have multiple and disseminated skin lesions than the B-cell lineage lymphoma cases. The lymphoma cell lineage did not significantly influence survival outcomes. Patients who showed cutaneous involvement within 6 months of the initial diagnosis of primary disease had a poorer overall survival (OS) outcome than patients who developed cutaneous dissemination 6 or more months after the initial diagnosis (P < 0·001). Patients with disseminated skin lesions had a poorer OS than patients with localized skin lesions (P = 0·028). The two lymphoma cell lineages differed in terms of prognostic factors that influenced survival.

Conclusions

Skin lesion characteristics such as time point of appearance and extent affect the survival outcomes of secondary cutaneous lymphoma. Cell lineage did not influence survival outcomes but the two lineages are associated with different prognostic factors.

References

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Secondary cutaneous lymphoma: comparative clinical features and survival outcome analysis of 106 cases according to lymphoma cell lineage

Summary

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Materials and methods

Results

Conclusions

References

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Secondary cutaneous lymphoma: comparative clinical features and survival outcome analysis of 106 cases according to lymphoma cell lineage

Summary

Background

Objectives

Materials and methods

Results

Conclusions

References

Citing Literature

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