The oestrogen receptor 2 (ESR2) gene in female-pattern hair loss: replication of association with rs10137185 in German patients
Corresponding Author
S. Redler
Institute of Human Genetics, University of Bonn, Sigmund-Freud-Street 25, D-53127 Bonn, Germany
E-mail: [email protected]Search for more papers by this authorP. Birch
Department of Dermatology, Royal Hallamshire Hospital, Sheffield, U.K
Search for more papers by this authorD. Drichel
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
Search for more papers by this authorP. Hofmann
Institute of Human Genetics, University of Bonn, Sigmund-Freud-Street 25, D-53127 Bonn, Germany
Department of Genomics, Life & Brain Center, University of Bonn, Sigmund-Freud-Street 25, D-53127 Bonn, Germany
Search for more papers by this authorK. Dobson
Department of Dermatology, Royal Hallamshire Hospital, Sheffield, U.K
Search for more papers by this authorA.C. Böhmer
Institute of Human Genetics, University of Bonn, Sigmund-Freud-Street 25, D-53127 Bonn, Germany
Department of Genomics, Life & Brain Center, University of Bonn, Sigmund-Freud-Street 25, D-53127 Bonn, Germany
Search for more papers by this authorJ. Becker
Institute of Human Genetics, University of Bonn, Sigmund-Freud-Street 25, D-53127 Bonn, Germany
Department of Genomics, Life & Brain Center, University of Bonn, Sigmund-Freud-Street 25, D-53127 Bonn, Germany
Search for more papers by this authorK.A. Giehl
Department of Dermatology, University of Munich, Munich, Germany
Search for more papers by this authorR. Tazi-Ahnini
Department of Infection and Immunity, University of Sheffield, Sheffield, U.K
Search for more papers by this authorH. Wolff
Department of Dermatology, University of Munich, Munich, Germany
Search for more papers by this authorA. Miesel
Department of Dermatology, University of Lübeck, Lübeck, Germany
Search for more papers by this authorT. Fischer
Department of Dermatology, University of Lübeck, Lübeck, Germany
Search for more papers by this authorM. Böhm
Department of Dermatology, Laboratory for Neuroendocrinology of the Skin and Interdisciplinary Endocrinology, University of Münster, Münster, Germany
Search for more papers by this authorR. Nuwayhid
Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany
Search for more papers by this authorN. Garcia Bartels
Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany
Search for more papers by this authorG. Lutz
Dermatological Practice, Hair & Nail, Wesseling, Germany
Search for more papers by this authorT. Becker
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
Institute for Medical Biometry Informatics and Epidemiology, University of Bonn, Sigmund-Freud-Street 25, D-53127 Bonn, Germany
Search for more papers by this authorU. Blume-Peytavi
Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany
Search for more papers by this authorM.M. Nöthen
Institute of Human Genetics, University of Bonn, Sigmund-Freud-Street 25, D-53127 Bonn, Germany
Department of Genomics, Life & Brain Center, University of Bonn, Sigmund-Freud-Street 25, D-53127 Bonn, Germany
Search for more papers by this authorA.G. Messenger
Department of Dermatology, Royal Hallamshire Hospital, Sheffield, U.K
Search for more papers by this authorR.C. Betz
Institute of Human Genetics, University of Bonn, Sigmund-Freud-Street 25, D-53127 Bonn, Germany
Search for more papers by this authorCorresponding Author
S. Redler
Institute of Human Genetics, University of Bonn, Sigmund-Freud-Street 25, D-53127 Bonn, Germany
E-mail: [email protected]Search for more papers by this authorP. Birch
Department of Dermatology, Royal Hallamshire Hospital, Sheffield, U.K
Search for more papers by this authorD. Drichel
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
Search for more papers by this authorP. Hofmann
Institute of Human Genetics, University of Bonn, Sigmund-Freud-Street 25, D-53127 Bonn, Germany
Department of Genomics, Life & Brain Center, University of Bonn, Sigmund-Freud-Street 25, D-53127 Bonn, Germany
Search for more papers by this authorK. Dobson
Department of Dermatology, Royal Hallamshire Hospital, Sheffield, U.K
Search for more papers by this authorA.C. Böhmer
Institute of Human Genetics, University of Bonn, Sigmund-Freud-Street 25, D-53127 Bonn, Germany
Department of Genomics, Life & Brain Center, University of Bonn, Sigmund-Freud-Street 25, D-53127 Bonn, Germany
Search for more papers by this authorJ. Becker
Institute of Human Genetics, University of Bonn, Sigmund-Freud-Street 25, D-53127 Bonn, Germany
Department of Genomics, Life & Brain Center, University of Bonn, Sigmund-Freud-Street 25, D-53127 Bonn, Germany
Search for more papers by this authorK.A. Giehl
Department of Dermatology, University of Munich, Munich, Germany
Search for more papers by this authorR. Tazi-Ahnini
Department of Infection and Immunity, University of Sheffield, Sheffield, U.K
Search for more papers by this authorH. Wolff
Department of Dermatology, University of Munich, Munich, Germany
Search for more papers by this authorA. Miesel
Department of Dermatology, University of Lübeck, Lübeck, Germany
Search for more papers by this authorT. Fischer
Department of Dermatology, University of Lübeck, Lübeck, Germany
Search for more papers by this authorM. Böhm
Department of Dermatology, Laboratory for Neuroendocrinology of the Skin and Interdisciplinary Endocrinology, University of Münster, Münster, Germany
Search for more papers by this authorR. Nuwayhid
Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany
Search for more papers by this authorN. Garcia Bartels
Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany
Search for more papers by this authorG. Lutz
Dermatological Practice, Hair & Nail, Wesseling, Germany
Search for more papers by this authorT. Becker
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
Institute for Medical Biometry Informatics and Epidemiology, University of Bonn, Sigmund-Freud-Street 25, D-53127 Bonn, Germany
Search for more papers by this authorU. Blume-Peytavi
Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany
Search for more papers by this authorM.M. Nöthen
Institute of Human Genetics, University of Bonn, Sigmund-Freud-Street 25, D-53127 Bonn, Germany
Department of Genomics, Life & Brain Center, University of Bonn, Sigmund-Freud-Street 25, D-53127 Bonn, Germany
Search for more papers by this authorA.G. Messenger
Department of Dermatology, Royal Hallamshire Hospital, Sheffield, U.K
Search for more papers by this authorR.C. Betz
Institute of Human Genetics, University of Bonn, Sigmund-Freud-Street 25, D-53127 Bonn, Germany
Search for more papers by this author
Supporting Information
Filename | Description |
---|---|
bjd12756-sup-0001-TableS1.pdfapplication/PDF, 271.6 KB | Table S1. Dominant and co-dominant model in the German and U.K. subgroups of mild, early and late affected FPHL samples. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
References
- 1Nyholt DR, Gillespie NA, Heath AC, Martin NG. Genetic basis of male pattern baldness. J Invest Dermatol 2003; 121: 1561–4.
- 2Smith MA, Wells RS. Male-type alopecia, alopecia areata, and normal hair in women; family histories. Arch Dermatol 1964; 89: 95–8.
- 3Redler S, Birch MP, Drichel D et al. Investigation of variants of the aromatase gene (CYP19A1) in female pattern hair loss. Br J Dermatol 2011; 165: 703–5.
- 4Redler S, Brockschmidt FF, Tazi-Ahnini R et al. Investigation of the male pattern baldness major genetic susceptibility loci AR/EDA2R and 20p11 in female pattern hair loss. Br J Dermatol 2012; 166: 1314–18.
- 5Redler S, Tazi-Ahnini R, Drichel D et al. Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: no association with female pattern hair loss identified. Exp Dermatol 2012; 21: 390–3.
- 6Yip L, Zaloumis S, Irwin D et al. Association analysis of oestrogen receptor beta gene (ESR2) polymorphisms with female pattern hair loss. Br J Dermatol 2012; 166: 1131–4.
- 7Ohnemus U, Uenalan M, Conrad F et al. Hair cycle control by estrogens: catagen induction via estrogen receptor (ER)-alpha is checked by ER beta signaling. Endocrinology 2005; 146: 1214–25.
- 8Ludwig E. Classification of the types of androgenetic alopecia (common baldness) occurring in the female sex. Br J Dermatol 1977; 97: 247–54.
- 9Sinclair R, Jolley D, Mallari R, Magee J. The reliability of horizontally sectioned scalp biopsies in the diagnosis of chronic diffuse telogen hair loss in women. J Am Acad Dermatol 2004; 51: 189–99.