Effect of broth from meat of linseed-fed cattle on glucose-stimulated insulin release in healthy male volunteers
Zoltan Bacs
Faculty of Economics and Business Administration, University of Debrecen, Debrecen, Hungary
Search for more papers by this authorKatalin Szabo
Faculty of Medicine, Department of Pharmacology and Pharmacotherapy, University of Debrecen, Debrecen, Hungary
Search for more papers by this authorLevente Czegledi
Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Debrecen, Hungary
Search for more papers by this authorJozsef Nemeth
Faculty of Medicine, Department of Pharmacology and Pharmacotherapy, University of Debrecen, Debrecen, Hungary
Search for more papers by this authorPeter Fraknoi
Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Debrecen, Hungary
Search for more papers by this authorPeter Kovacs
Faculty of Medicine, Institute of Internal Medicine Building A, University of Debrecen, Debrecen, Hungary
Search for more papers by this authorAndras Javor
Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Debrecen, Hungary
Search for more papers by this authorBalazs Varga
Faculty of Medicine, Department of Pharmacology and Pharmacotherapy, University of Debrecen, Debrecen, Hungary
Search for more papers by this authorCorresponding Author
Bela Juhasz
Faculty of Medicine, Department of Pharmacology and Pharmacotherapy, University of Debrecen, Debrecen, Hungary
Correspondence
Bela Juhasz, Faculty of Medicine, Department of Pharmacology and Pharmacotherapy, University of Debrecen, Debrecen, Hungary.
Email: [email protected]
Search for more papers by this authorZoltan Szilvassy
Faculty of Medicine, Department of Pharmacology and Pharmacotherapy, University of Debrecen, Debrecen, Hungary
Search for more papers by this authorZoltan Bacs
Faculty of Economics and Business Administration, University of Debrecen, Debrecen, Hungary
Search for more papers by this authorKatalin Szabo
Faculty of Medicine, Department of Pharmacology and Pharmacotherapy, University of Debrecen, Debrecen, Hungary
Search for more papers by this authorLevente Czegledi
Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Debrecen, Hungary
Search for more papers by this authorJozsef Nemeth
Faculty of Medicine, Department of Pharmacology and Pharmacotherapy, University of Debrecen, Debrecen, Hungary
Search for more papers by this authorPeter Fraknoi
Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Debrecen, Hungary
Search for more papers by this authorPeter Kovacs
Faculty of Medicine, Institute of Internal Medicine Building A, University of Debrecen, Debrecen, Hungary
Search for more papers by this authorAndras Javor
Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Debrecen, Hungary
Search for more papers by this authorBalazs Varga
Faculty of Medicine, Department of Pharmacology and Pharmacotherapy, University of Debrecen, Debrecen, Hungary
Search for more papers by this authorCorresponding Author
Bela Juhasz
Faculty of Medicine, Department of Pharmacology and Pharmacotherapy, University of Debrecen, Debrecen, Hungary
Correspondence
Bela Juhasz, Faculty of Medicine, Department of Pharmacology and Pharmacotherapy, University of Debrecen, Debrecen, Hungary.
Email: [email protected]
Search for more papers by this authorZoltan Szilvassy
Faculty of Medicine, Department of Pharmacology and Pharmacotherapy, University of Debrecen, Debrecen, Hungary
Search for more papers by this authorAbstract
Polyunsaturated fatty acid consumption has been shown to improve insulin sensitivity. We studied if administration of broth with beef meat enriched with polyunsaturated fatty acids influenced glucose-stimulated insulin release in healthy male volunteers. Broth was made either from cattles undergone dietary supplementation with lightly bruised whole linseed in addition to feeding ad libitum on grass silage (test meal) or from those fed grass silage alone (control meal). Oral glucose tolerance tests (OGTT) were performed in patients after a 6-day period of eating 300 ml broth containing 100 g meat once a day in addition to their otherwise normal mixed nourishment. During OGTT, blood samples were taken for blood glucose level and plasma insulin immunoreactivity before and 15, 30, 60, 90, 120, and 180 min after the glucose load. Glucose-stimulated maximum increase in plasma insulin immunoreactivity was 42 ± 6.6 and 81 ± 7.4 mU/ml (p < 0.05) after the test and the control meals, respectively. However, both fasting and postload blood glucose levels were the same after either meal period. The results suggest an insulin-sensitizing effect of food produced from beef cattle maintained on linseed diet in healthy human volunteers.
REFERENCES
- Ashes, J. R., Siebert, B. D., Gulati, S. K., Cuthbertson, A. Z., & Scott, T. W. (1992). Incorporation of n-3 fatty acids of fish oil into tissue and serum lipids of ruminants. Lipids, 27, 629–631. https://doi.org/10.1007/BF02536122
- Cavaliere, G., Trinchese, G., Bergamo, P., De Filippo, C., Mattace Raso, G., Gifuni, G., … Mollica, M. P. (2016). Polyunsaturated fatty acids attenuate diet induced obesity and insulin resistance, modulating mitochondrial respiratory uncoupling in rat skeletal muscle. PLoS ONE, 11, e0149033. https://doi.org/10.1371/journal.pone.0149033
- Cook, L. J., Scott, T. W., Faichney, G. J., & Davies, H. L. (1972). Fatty acid interrelationships in plasma, liver, muscle and adipose tissues of cattle fed safflower oil protected from ruminal hydrogenation. Lipids, 7, 83–89. https://doi.org/10.1007/BF02532592
- Czegledi, L., Tamas, A., Borzsei, R., Bagoly, T., Kiss, P., Horvath, G., … Helyes, Z. (2011). Presence of pituitary adenylate cyclase-activating polypeptide (PACAP) in the plasma and milk of ruminant animals. General and Comparative Endocrinology, 172, 115–119. https://doi.org/10.1016/j.ygcen.2010.12.012
- Dewhurst, R., Aston, K., Fisher, W., Evans, R., Dhanoa, M., & McAllan, A. (1999). Comparison of energy and protein sources offered at low levels in grass-silage-based diets for dairy cows. Animal Science, 68, 789–799. https://doi.org/10.1017/S1357729800050815
10.1017/S1357729800050815 Google Scholar
- Diane, A., Borthwick, F., Mapiye, C., Vahmani, P., David, R. C., Vine, D. F., … Proctor, S. D. (2016). Beef Fat enriched with polyunsaturated fatty acid biohydrogenation products improves insulin sensitivity without altering dyslipidemia in insulin resistant JCR:LA-cp Rats. Lipids, 51, 821–831. https://doi.org/10.1007/s11745-016-4148-7
- Dyerberg, J., Bang, H. O., Stoffersen, E., Moncada, S., & Vane, J. R. (1978). Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? Lancet, 2, 117–119. https://doi.org/10.1016/S0140-6736(78)91505-2
- Enser, M., Hallett, K., Hewitt, B., Fursey, G. A., & Wood, J. D. (1996). Fatty acid content and composition of English beef, lamb and pork at retail. Meat Science, 42, 443–456. https://doi.org/10.1016/0309-1740(95)00037-2
- Fedor, D., & Kelley, D. S. (2009). Prevention of insulin resistance by n-3 polyunsaturated fatty acids. Current Opinion in Clinical Nutrition and Metabolic Care, 12, 138–146. https://doi.org/10.1097/MCO.0b013e3283218299
- Folch, J., Lees, M., & Sloane Stanley, G. H. (1957). A simple method for the isolation and purification of total lipides from animal tissues. The Journal of Biological Chemistry, 226, 497–509.
- Hay, J. D., & Morrison, W. R. (1973). Positional isomers of Cis and Trans monoenoic fatty acids from ox (steer) perinephric fat. Lipids, 8, 94–95. https://doi.org/10.1007/BF02534337
- Jump, D. B., Depner, C. M., & Tripathy, S. (2012). Omega-3 fatty acid supplementation and cardiovascular disease. Journal of Lipid Research, 53, 2525–2545. https://doi.org/10.1194/jlr.R027904
- Koizumi, I., Suzuki, Y., & Kaneko, J. J. (1991). Studies on the fatty acid composition of intramuscular lipids of cattle, pigs and birds. Journal of Nutritional Science and Vitaminology, 37, 545–554. https://doi.org/10.3177/jnsv.37.545
- Kovacs, P., Szilvassy, Z., Hegyi, P., Nemeth, J., Ferdinandy, P., & Tosaki, A. (2000). Effect of transdermal nitroglycerin on glucose-stimulated insulin release in healthy male volunteers. European Journal of Clinical Investigation, 30, 41–44. https://doi.org/10.1046/j.1365-2362.2000.00588.x
- Lalia, A. Z., & Lanza, I. R. (2016). Insulin-sensitizing effects of omega-3 fatty acids: lost in translation? Nutrients, 8, 329.
- Mitchell, G. E., Reed, A. W., & Rogers, S. A. (1991). Influence of feeding regimen on the sensory qualities and fatty acid contents of beef steaks. Journal of Food Science, 56, 1102–1103. https://doi.org/10.1111/j.1365-2621.1991.tb14652.x
- Rudkowska, I. (2009). Functional foods for health: Focus on diabetes. Maturitas, 62, 263–269. https://doi.org/10.1016/j.maturitas.2009.01.011
- Scollan, N. D., Choi, N. J., Kurt, E., Fisher, A. V., Enser, M., & Wood, J. D. (2001). Manipulating the fatty acid composition of muscle and adipose tissue in beef cattle. The British Journal of Nutrition, 85, 115–124. https://doi.org/10.1079/BJN2000223
- Syngai, G. G., Gopi, R., Bharali, R., Dey, S., Lakshmanan, G. M., & Ahmed, G. (2016). Probiotics - the versatile functional food ingredients. Journal of Food Science and Technology, 53, 921–933. https://doi.org/10.1007/s13197-015-2011-0
- Ungvari, E., Monori, I., Megyeri, A., Csiki, Z., Prokisch, J., Sztrik, A., … Benko, I. (2014). Protective effects of meat from lambs on selenium nanoparticle supplemented diet in a mouse model of polycyclic aromatic hydrocarbon-induced immunotoxicity. Food and Chemical Toxicology, 64, 298–306. https://doi.org/10.1016/j.fct.2013.12.004
- Wallenstein, S., Zucker, C. L., & Fleiss, J. L. (1980). Some statistical methods useful in circulation research. Circulation Research, 47, 769–9. https://doi.org/10.1161/01.RES.47.1.1
