ST2 and IL-33 polymorphisms and the development of childhood asthma: a prospective birth cohort study in Finnish children
Johanna T. Teräsjärvi
Institute of Biomedicine, Research Centre for Infections and Immunity, University of Turku, Turku, Finland
Search for more papers by this authorLaura Toivonen
Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland
Search for more papers by this authorJussi Mertsola
Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland
Search for more papers by this authorVille Peltola
Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland
InFLAMES Research Flagship Centre, University of Turku, Turku, Finland
Search for more papers by this authorCorresponding Author
Qiushui He
Institute of Biomedicine, Research Centre for Infections and Immunity, University of Turku, Turku, Finland
InFLAMES Research Flagship Centre, University of Turku, Turku, Finland
Qiushui He, Institute of Biomedicine, Research Centre for Infections and Immunity, University of Turku, Kiinamyllynkatu 10, Turku 20520, Finland. e-mail: [email protected]
Search for more papers by this authorJohanna T. Teräsjärvi
Institute of Biomedicine, Research Centre for Infections and Immunity, University of Turku, Turku, Finland
Search for more papers by this authorLaura Toivonen
Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland
Search for more papers by this authorJussi Mertsola
Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland
Search for more papers by this authorVille Peltola
Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland
InFLAMES Research Flagship Centre, University of Turku, Turku, Finland
Search for more papers by this authorCorresponding Author
Qiushui He
Institute of Biomedicine, Research Centre for Infections and Immunity, University of Turku, Turku, Finland
InFLAMES Research Flagship Centre, University of Turku, Turku, Finland
Qiushui He, Institute of Biomedicine, Research Centre for Infections and Immunity, University of Turku, Kiinamyllynkatu 10, Turku 20520, Finland. e-mail: [email protected]
Search for more papers by this authorAbstract
The ST2/IL-33 signaling pathway has an important role in the host inflammatory response. Here we aimed to study the association of ST2 and IL-33 polymorphisms with serum soluble (s) ST2 and IL-33 concentrations in healthy Finnish children and, in addition, their association with childhood asthma. In total, 146 children were followed from birth to the age 7 years for the development of asthma. Single-nucleotide polymorphisms (SNPs) in ST2 and IL-33 were determined, and associations of the SNP variants with serum levels of sST2 and IL-33 at age of 13 months and with recurrent wheezing and childhood asthma at 7 years of age were analyzed. Children with ST2 rs1041973 AC/AA genotypes had significantly lower level of serum sST2 (2453 pg/mL; IQR 2265) than those with CC genotype (5437 pg/mL; IQR 2575; p = < 0.0001). Similar difference was also observed with ST2 rs13408661. No differences were observed between subjects with studied IL-33 SNPs. Children who carried genetic variants of ST2 rs1041973 or rs13408661 seemed to have a higher risk of asthma. In contrast, children who carried genetic variants of IL-33 rs12551268 were less often diagnosed with asthma. Even though these SNPs seemed to associate with asthma, the differences were not statistically significant.
CONFLICT OF INTEREST
On behalf of all authors, the corresponding author states that there is no conflict of interest.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
| Filename | Description |
|---|---|
| apm13411-sup-0001-TableS1.docxWord 2007 document , 14.9 KB | Table S1. Primers used in the study. |
| apm13411-sup-0002-TableS2.docxWord 2007 document , 18.9 KB | Table S2. Serum sST2 and IL-33 levels in individuals with and without ST2 and IL-33 polymorphisms. |
| apm13411-sup-0003-TableS3.docxWord 2007 document , 18.1 KB | Table S3. Serum sST2 and IL-33 levels in individuals with different haplotypes of ST2 and IL-33 polymorphisms. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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