Analysis of iron acquisition and storage-related genes in clinical and non-clinical strains of Yersinia enterocolitica biovar 1A
Pawan Kumar Kanaujia
Microbial Pathogenicity Laboratory, Department of Microbiology, University of Delhi South Campus, New Delhi, India
Search for more papers by this authorPriyanka Bajaj
Microbial Pathogenicity Laboratory, Department of Microbiology, University of Delhi South Campus, New Delhi, India
Search for more papers by this authorCorresponding Author
Jugsharan Singh Virdi
Microbial Pathogenicity Laboratory, Department of Microbiology, University of Delhi South Campus, New Delhi, India
Jugsharan Singh Virdi, Microbial Pathogenicity Laboratory, Department of Microbiology, University of Delhi South Campus, Benito Juarez Road, New Delhi, 110021, India. e-mail: [email protected]Search for more papers by this authorPawan Kumar Kanaujia
Microbial Pathogenicity Laboratory, Department of Microbiology, University of Delhi South Campus, New Delhi, India
Search for more papers by this authorPriyanka Bajaj
Microbial Pathogenicity Laboratory, Department of Microbiology, University of Delhi South Campus, New Delhi, India
Search for more papers by this authorCorresponding Author
Jugsharan Singh Virdi
Microbial Pathogenicity Laboratory, Department of Microbiology, University of Delhi South Campus, New Delhi, India
Jugsharan Singh Virdi, Microbial Pathogenicity Laboratory, Department of Microbiology, University of Delhi South Campus, Benito Juarez Road, New Delhi, 110021, India. e-mail: [email protected]Search for more papers by this authorAbstract
Possession of mechanisms for iron acquisition and its storage enhances the ability of the bacteria to survive in the iron-limiting environment of the host. In this study, 81 strains of Yersinia enterocolitica biovar 1A isolated from various clinical (n = 51) and non-clinical (n = 30) sources were investigated for the presence of the genes related to iron acquisition and storage. Important genes which were present in more than 85% of the strains included hasA, foxA, bfr, bfd, ftnA, and hmsT as well as the fhuCDB, fepBDGCfesfepA, feoAB, yfuABCD, hemPRSTUV, and hmsHFRS gene clusters. Majority of these genes is being reported for the first time in biovar 1A strains and showed significant homology with genes present in the known pathogenic biovars of Y. enterocolitica. However, no significant difference was observed in the distribution of iron acquisition and storage-related genes among clinical and non-clinical biovar 1A strains. Thus, it may be suggested that the presence of iron acquisition and storage-related genes per se might not be responsible for the supposedly better ability of clinical biovar 1A strains to cause infections in humans. However, in the backdrop of this data, the need to undertake functional studies are highly recommended.
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