Volume 106, Issue 11 pp. 1767-1771

Regular Article

Maternal intrapartum antibiotic treatment continues to exert a bactericidal effect on the umbilical cord and peripheral venous blood of newborn infants

C Hershkovich–Shporen,

C Hershkovich–Shporen

Department of Neonatology, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem, Israel

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R Bardenstein,

R Bardenstein

Department of Microbiology, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem, Israel

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I Blickstein,

I Blickstein

Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem, Israel

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E S Shinwell,

E S Shinwell

Department of Neonatology, Ziv Medical Center, Tsfat, Faculty of Medicine in the Galil, Bar-Ilan University, Ramat Gan, Israel

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O Flidel-Rimon,

Corresponding Author

O Flidel-Rimon

[email protected]

Department of Neonatology, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem, Israel

Correspondence

O. Flidel-Rimon, Department of Neonatology, Kaplan Medical Center, P.O. Box 1, Rehovot, Israel.

Tel: 972-8-9441218 |

Fax: 972-8-9441768 |

E-mail: [email protected]

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C Hershkovich–Shporen,

C Hershkovich–Shporen

Department of Neonatology, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem, Israel

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R Bardenstein,

R Bardenstein

Department of Microbiology, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem, Israel

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I Blickstein,

I Blickstein

Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem, Israel

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E S Shinwell,

E S Shinwell

Department of Neonatology, Ziv Medical Center, Tsfat, Faculty of Medicine in the Galil, Bar-Ilan University, Ramat Gan, Israel

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O Flidel-Rimon,

Corresponding Author

O Flidel-Rimon

[email protected]

Department of Neonatology, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem, Israel

Correspondence

O. Flidel-Rimon, Department of Neonatology, Kaplan Medical Center, P.O. Box 1, Rehovot, Israel.

Tel: 972-8-9441218 |

Fax: 972-8-9441768 |

E-mail: [email protected]

Search for more papers by this author

First published: 11 July 2017

https://doi.org/10.1111/apa.13982

Citations: 1

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Abstract

Aim

It is unclear whether maternal intrapartum antibiotic treatment (IAT) continues to exert a bactericidal effect on common pathogens in neonates. We studied the in vitro bactericidal effect of IAT on the cord and peripheral venous blood of newborn infants.

Methods

Umbilical cord and peripheral venous blood from newborn infants born at Kaplan Medical Center, Israel, from April to October 2014 were studied for serum bactericidal titres against Group B Streptococcus (GBS) and Escherichia coli (E. coli) strains. We studied 60 samples of umbilical cord blood and 18 samples of peripheral venous blood from 60 newborn infants whose mothers received IAT. The controls were 10 samples of cord blood from mothers without IAT.

Results

Cord blood exerted a bactericidal effect against 98% of GBS isolates but only 8% of E.coli isolates. Peripheral blood exerted a bactericidal effect against GBS in 94% of cases, but not against E. coli. No bactericidal effect was seen in the blood from the controls.

Conclusion

We found a continued bactericidal effect of umbilical cord blood and neonatal peripheral blood from newborn infants of IAT-treated mothers, mainly against GBS, but rarely against E. Coli. These findings may assist clinicians treating at-risk infants exposed to IAT.

References

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Volume106, Issue11

November 2017

Pages 1767-1771

Maternal intrapartum antibiotic treatment continues to exert a bactericidal effect on the umbilical cord and peripheral venous blood of newborn infants

Abstract

Aim

Methods

Results

Conclusion

References

Citing Literature

References

Information

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Maternal intrapartum antibiotic treatment continues to exert a bactericidal effect on the umbilical cord and peripheral venous blood of newborn infants

Abstract

Aim

Methods

Results

Conclusion

References

Citing Literature

References

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