Review Article
Autism spectrum disorders: linking neuropathological findings to treatment with transcranial magnetic stimulation
Manuel F. Casanova,
Estate Sokhadze,
Ioan Opris,
Yao Wang,
Xiaoli Li,
Corresponding Author
Manuel F. Casanova
Department of Psychiatry, University of Louisville, Louisville, KA, USA
Correspondence
M F Casanova, MD, Gottfried and Gisela Kolb Endowed Chair in Psychiatry, Department of Psychiatry, University of Louisville, 500 South Preston Street, Bldg A, Rm 217, Louisville, KY 40202, USA
Tel.: +1(502)852-4077 |
Email: [email protected]
Search for more papers by this authorEstate Sokhadze
Department of Psychiatry, University of Louisville, Louisville, KA, USA
Search for more papers by this authorIoan Opris
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NA, USA
Search for more papers by this authorYao Wang
Department of Psychiatry, University of Louisville, Louisville, KA, USA
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
Search for more papers by this authorXiaoli Li
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
Search for more papers by this authorManuel F. Casanova,
Estate Sokhadze,
Ioan Opris,
Yao Wang,
Xiaoli Li,
Corresponding Author
Manuel F. Casanova
Department of Psychiatry, University of Louisville, Louisville, KA, USA
Correspondence
M F Casanova, MD, Gottfried and Gisela Kolb Endowed Chair in Psychiatry, Department of Psychiatry, University of Louisville, 500 South Preston Street, Bldg A, Rm 217, Louisville, KY 40202, USA
Tel.: +1(502)852-4077 |
Email: [email protected]
Search for more papers by this authorEstate Sokhadze
Department of Psychiatry, University of Louisville, Louisville, KA, USA
Search for more papers by this authorIoan Opris
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NA, USA
Search for more papers by this authorYao Wang
Department of Psychiatry, University of Louisville, Louisville, KA, USA
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
Search for more papers by this authorXiaoli Li
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
Search for more papers by this authorAbstract
Postmortem studies in autism spectrum disorder (ASD) individuals indicate the presence of abnormalities within the peripheral neuropil space (PNS) of cortical minicolumns. The geometrical orientation of inhibitory elements within the PNS suggests using repetitive transcranial magnetic stimulation (rTMS) to up-regulate their activity. Several rTMS trials in ASD have shown marked improvements in motor symptomatology, attention and perceptual binding.Conclusion: rTMS is the first therapeutic attempt at ASD aimed at correcting some of its core pathology.
Graphical Abstract
References
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