Association of hypogonadism symptoms and serum hormones in aging males
Guoqing Liang
Department of Urology, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorYuxuan Song
Department of Urology, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorLi Liu
Department of Urology, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorKechong Zhou
Department of Urology, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorJia Tian
Department of Urology, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorJianhui Li
Department of Reproductive Epidemiology and Social Science, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China
Search for more papers by this authorHuijuan Shi
Department of Reproductive Epidemiology and Social Science, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China
Search for more papers by this authorQianxi Zhu
Department of Reproductive Epidemiology and Social Science, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China
Search for more papers by this authorJun Wang
Department of Urology, The First People’s Hospital of Jiashan, Zhejiang, China
Search for more papers by this authorJunbiao Zheng
Department of Urology, The First People’s Hospital of Jiashan, Zhejiang, China
Search for more papers by this authorXiaohua Yu
Department of Urology, The First People’s Hospital of Jiashan, Zhejiang, China
Search for more papers by this authorShucheng Zhang
Department of Cell Biology, National Research Institute of Family Planning, Beijing, China
Search for more papers by this authorZheng Li
Department of Andrology, Shanghai general Hospital, Shanghai Jiaotong University, Shanghai, China
Search for more papers by this authorCorresponding Author
Xiaoqiang Liu
Department of Urology, Tianjin Medical University General Hospital, Tianjin, China
Correspondence
Xiaoqiang Liu, Department of Urology, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin 300052, China.
Email: [email protected]
Search for more papers by this authorGuoqing Liang
Department of Urology, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorYuxuan Song
Department of Urology, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorLi Liu
Department of Urology, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorKechong Zhou
Department of Urology, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorJia Tian
Department of Urology, Tianjin Medical University General Hospital, Tianjin, China
Search for more papers by this authorJianhui Li
Department of Reproductive Epidemiology and Social Science, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China
Search for more papers by this authorHuijuan Shi
Department of Reproductive Epidemiology and Social Science, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China
Search for more papers by this authorQianxi Zhu
Department of Reproductive Epidemiology and Social Science, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China
Search for more papers by this authorJun Wang
Department of Urology, The First People’s Hospital of Jiashan, Zhejiang, China
Search for more papers by this authorJunbiao Zheng
Department of Urology, The First People’s Hospital of Jiashan, Zhejiang, China
Search for more papers by this authorXiaohua Yu
Department of Urology, The First People’s Hospital of Jiashan, Zhejiang, China
Search for more papers by this authorShucheng Zhang
Department of Cell Biology, National Research Institute of Family Planning, Beijing, China
Search for more papers by this authorZheng Li
Department of Andrology, Shanghai general Hospital, Shanghai Jiaotong University, Shanghai, China
Search for more papers by this authorCorresponding Author
Xiaoqiang Liu
Department of Urology, Tianjin Medical University General Hospital, Tianjin, China
Correspondence
Xiaoqiang Liu, Department of Urology, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin 300052, China.
Email: [email protected]
Search for more papers by this authorGuoqing Liang, Yuxuan Song, Li Liu and Kechong Zhou contributed equally to this work
Abstract
The association between hypogonadism symptoms and the levels of serum hormones are still in debate. To investigate the relationship between hypogonadism symptoms and serum hormones in middle-aged and elderly Chinese men, this community-based cross-sectional study was conducted based on a total of 965 ageing men. The ageing males’ symptom (AMS) scale, International Index of Erectile Function-5 (IIEF-5), International Prostate Symptom Score (IPSS) questionnaires and related variables were assessed. Blood tests for total testosterone (TT), sex hormone-binding globulin (SHBG) and luteinising hormone (LH) were performed. Serum level of free testosterone (FT) and bioavailable testosterone (Bio-T) was calculated. The mean age was 56.34 ± 8.85 years. Total AMS score was significantly associated with all five serum hormones (LH: p < 0.001; SHBG: p < 0.001; TT: p =.043; FT: p = 0.007; Bio-T: p < 0.001). We identified sexual and somatic symptoms were obviously related to five serum hormones, while psychological symptoms seemed to have no association with serum hormones. After adjusting for age and BMI, multiple linear regression analysis indicated that LH had positive correlations with total AMS score, somatic and sexual symptom score (p < 0.05). In conclusion, LH and SHBG had the strongest correlation hypogonadism and might be used as early predictors for symptomatic hypogonadism in the near future.
Open Research
DATA AVAILABILITY STATEMENT
Data available on request from the authors.
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