Opisthorchis felineus negatively associates with skin test reactivity in Russia—EuroPrevall-International Cooperation study
O. S. Fedorova
Department of Faculty Pediatrics, Siberian State Medical University, Tomsk, Russian Federation
These authors contributed equally.Search for more papers by this authorJ. J. Janse
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
These authors contributed equally.Search for more papers by this authorL. M. Ogorodova
Department of Faculty Pediatrics, Siberian State Medical University, Tomsk, Russian Federation
Search for more papers by this authorM. M. Fedotova
Department of Faculty Pediatrics, Siberian State Medical University, Tomsk, Russian Federation
Search for more papers by this authorR. A. Achterberg
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
Search for more papers by this authorJ. J. Verweij
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
Search for more papers by this authorM. Fernández-Rivas
Servicio de Alergia, Hospital Clínico San Carlos, IdISSC, Madrid, Spain
Search for more papers by this authorS. A. Versteeg
Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
Search for more papers by this authorJ. Potts
Department of Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College London, London, UK
Search for more papers by this authorC. Minelli
Department of Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College London, London, UK
Search for more papers by this authorR. van Ree
Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
Search for more papers by this authorP. Burney
Department of Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College London, London, UK
Search for more papers by this authorCorresponding Author
M. Yazdanbakhsh
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
Correspondence
Prof. Dr. Maria Yazdanbakhsh, Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
Tel.: +31 71 5265067
Fax: +31 71 5266907
E-mail: [email protected]
Search for more papers by this authorO. S. Fedorova
Department of Faculty Pediatrics, Siberian State Medical University, Tomsk, Russian Federation
These authors contributed equally.Search for more papers by this authorJ. J. Janse
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
These authors contributed equally.Search for more papers by this authorL. M. Ogorodova
Department of Faculty Pediatrics, Siberian State Medical University, Tomsk, Russian Federation
Search for more papers by this authorM. M. Fedotova
Department of Faculty Pediatrics, Siberian State Medical University, Tomsk, Russian Federation
Search for more papers by this authorR. A. Achterberg
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
Search for more papers by this authorJ. J. Verweij
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
Search for more papers by this authorM. Fernández-Rivas
Servicio de Alergia, Hospital Clínico San Carlos, IdISSC, Madrid, Spain
Search for more papers by this authorS. A. Versteeg
Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
Search for more papers by this authorJ. Potts
Department of Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College London, London, UK
Search for more papers by this authorC. Minelli
Department of Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College London, London, UK
Search for more papers by this authorR. van Ree
Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
Search for more papers by this authorP. Burney
Department of Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College London, London, UK
Search for more papers by this authorCorresponding Author
M. Yazdanbakhsh
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
Correspondence
Prof. Dr. Maria Yazdanbakhsh, Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
Tel.: +31 71 5265067
Fax: +31 71 5266907
E-mail: [email protected]
Search for more papers by this authorAbstract
Background
Most studies on the relationship between helminth infections and atopic disorders have been conducted in (sub)tropical developing countries where exposure to multiple parasites and lifestyle can confound the relationship. We aimed to study the relationship between infection with the fish-borne helminth Opishorchis felineus and specific IgE, skin prick testing, and atopic symptoms in Western Siberia, with lifestyle and hygiene standards of a developed country.
Methods
Schoolchildren aged 7–11 years were sampled from one urban and two rural regions. Skin prick tests (SPT) and specific IgE (sIgE) against food and aeroallergens were measured, and data on allergic symptoms and on demographic and socioeconomic factors were collected by questionnaire. Diagnosis of opisthorchiasis was based on PCR performed on stool samples.
Results
Of the 732 children included, 34.9% had opisthorchiasis. The sensitization to any allergen when estimated by positive SPT was 12.8%, while much higher, 24.0%, when measured by sIgE. Atopic symptoms in the past year (flexural eczema and/or rhinoconjunctivitis) were reported in 12.4% of the children. SPT was positively related to flexural eczema and rhinoconjunctivitis, but not to wheezing. Opisthorchiasis showed association with lower SPT response, as well as borderline association with low IgE reactivity to any allergen. However, the effect of opisthorchiasis on SPT response was not mediated by IgE, suggesting that opisthorchiasis influences SPT response through another mechanism. Opisthorchiasis also showed borderline association with lower atopic symptoms.
Conclusions
There is a negative association between a chronic helminth infection and skin prick test reactivity even in a developed country.
Supporting Information
| Filename | Description |
|---|---|
| all13120-sup-0001-FigS1.TIFFTIFF image, 307.6 KB | Figure S1. Overview of stages of the study design with calculation of weighting factors. |
| all13120-sup-0002-Supinfo.docxWord document, 65.8 KB |
Appendix S1. Food allergy screening questionnaire for children. Appendix S2. PCR and DNA isolation for determination of infection. Table S1. Sensitization (positive SPT and sIgE) to all allergens tested. Table S2. Unweighted percentage of histamine negatives per group in the study sample (N = 732). Table S3. Association between specific IgE, SPT and symptoms in the past 12 months. Table S4. Univariate weighted models for IgE and SPT to food and aero allergen. Table S5. Univariate weighted models for wheezing, rhinoconjunctivitis and flexural eczema in the past 12 months. Table S6. Adjusted weighted models for the association between opisthorchiasis and SPT outcomes, including all children (i.e. including histamine negatives). |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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