Functional properties of peripheral CD8+ T cells in patients with repeated implantation failure
Biao Yin
The State Key Laboratory of Medical Genetics of China, Central South University, Changsha, China
Shenzhen Key Laboratory for Reproductive Immunology of Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China
Search for more papers by this authorYong Zeng
Shenzhen Key Laboratory for Reproductive Immunology of Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China
Search for more papers by this authorTonghua Wu
Shenzhen Key Laboratory for Reproductive Immunology of Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China
Search for more papers by this authorShuyi Yu
Shenzhen Key Laboratory for Reproductive Immunology of Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China
Search for more papers by this authorJian Xu
Shenzhen Key Laboratory for Reproductive Immunology of Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China
Search for more papers by this authorSu Liu
Shenzhen Key Laboratory for Reproductive Immunology of Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China
Search for more papers by this authorLianghui Diao
Shenzhen Key Laboratory for Reproductive Immunology of Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China
Search for more papers by this authorZhenfu Zhao
School of Medicine, Shenzhen University, Shenzhen, Guangdong, China
Search for more papers by this authorCorresponding Author
Desheng Liang
The State Key Laboratory of Medical Genetics of China, Central South University, Changsha, China
Correspondence
Yuye Li, Shenzhen Key Laboratory for Reproductive Immunology of Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China.
Email: [email protected]
and
Desheng Liang, The State Key Laboratory of Medical Genetics of China, Central South University, Changsha, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Yuye Li
Shenzhen Key Laboratory for Reproductive Immunology of Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China
Correspondence
Yuye Li, Shenzhen Key Laboratory for Reproductive Immunology of Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China.
Email: [email protected]
and
Desheng Liang, The State Key Laboratory of Medical Genetics of China, Central South University, Changsha, China.
Email: [email protected]
Search for more papers by this authorBiao Yin
The State Key Laboratory of Medical Genetics of China, Central South University, Changsha, China
Shenzhen Key Laboratory for Reproductive Immunology of Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China
Search for more papers by this authorYong Zeng
Shenzhen Key Laboratory for Reproductive Immunology of Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China
Search for more papers by this authorTonghua Wu
Shenzhen Key Laboratory for Reproductive Immunology of Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China
Search for more papers by this authorShuyi Yu
Shenzhen Key Laboratory for Reproductive Immunology of Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China
Search for more papers by this authorJian Xu
Shenzhen Key Laboratory for Reproductive Immunology of Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China
Search for more papers by this authorSu Liu
Shenzhen Key Laboratory for Reproductive Immunology of Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China
Search for more papers by this authorLianghui Diao
Shenzhen Key Laboratory for Reproductive Immunology of Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China
Search for more papers by this authorZhenfu Zhao
School of Medicine, Shenzhen University, Shenzhen, Guangdong, China
Search for more papers by this authorCorresponding Author
Desheng Liang
The State Key Laboratory of Medical Genetics of China, Central South University, Changsha, China
Correspondence
Yuye Li, Shenzhen Key Laboratory for Reproductive Immunology of Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China.
Email: [email protected]
and
Desheng Liang, The State Key Laboratory of Medical Genetics of China, Central South University, Changsha, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Yuye Li
Shenzhen Key Laboratory for Reproductive Immunology of Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China
Correspondence
Yuye Li, Shenzhen Key Laboratory for Reproductive Immunology of Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China.
Email: [email protected]
and
Desheng Liang, The State Key Laboratory of Medical Genetics of China, Central South University, Changsha, China.
Email: [email protected]
Search for more papers by this authorAbstract
CD8+ T cells are the main candidates to recognize and respond to fetal HLA-C at the fetal-maternal interface, but data on the amount of peripheral CD8+ T cells and their functions during the window of implantation in recurrent implantation failure (RIF) patients are limited. Peripheral blood was obtained from 56 women with RIF and 16 fertile women in the mid-luteal phase of the menstrual cycle, and the CD8+ T cells were determined by FACS analysis. No statistical differences in the proportion of peripheral CD8+ T cells were observed among the women with RIF and the control group. However, the levels of IFN-γ+ and TNF-α+ CD8+ T cells in the RIF group were significantly higher than those in the control group. The cytolytic activity and regulatory proportion of CD8+ T cells in RIF were similar to that in the control group. Our data indicated that the elevated expression levels of IFN-γ and TNF-α in peripheral CD8+ T cells may contribute to an impaired immune tolerance in women with RIF.
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