Modulatory effects of vitamin D on peripheral cellular immunity in patients with recurrent miscarriage
Xian Chen
Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China
These authors contributed equally to the study.Search for more papers by this authorBiao Yin
The State Key Laboratory of Medical Genetics of China, Central South University, Changsha, Hunan, China
These authors contributed equally to the study.Search for more papers by this authorRuo-Chun Lian
Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China
Search for more papers by this authorTao Zhang
Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China
Search for more papers by this authorHong-Zhan Zhang
Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China
Search for more papers by this authorLiang-Hui Diao
Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China
Search for more papers by this authorYu-Ye Li
Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China
Search for more papers by this authorChun-Yu Huang
Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China
Search for more papers by this authorCorresponding Author
De-Sheng Liang
The State Key Laboratory of Medical Genetics of China, Central South University, Changsha, Hunan, China
Correspondence
Yong Zeng, Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China.
Email: [email protected]
and
De-Sheng Liang, The State Key Laboratory of Medical Genetics of China, Central South University, Changsha, Hunan, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Yong Zeng
Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China
Correspondence
Yong Zeng, Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China.
Email: [email protected]
and
De-Sheng Liang, The State Key Laboratory of Medical Genetics of China, Central South University, Changsha, Hunan, China.
Email: [email protected]
Search for more papers by this authorXian Chen
Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China
These authors contributed equally to the study.Search for more papers by this authorBiao Yin
The State Key Laboratory of Medical Genetics of China, Central South University, Changsha, Hunan, China
These authors contributed equally to the study.Search for more papers by this authorRuo-Chun Lian
Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China
Search for more papers by this authorTao Zhang
Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China
Search for more papers by this authorHong-Zhan Zhang
Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China
Search for more papers by this authorLiang-Hui Diao
Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China
Search for more papers by this authorYu-Ye Li
Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China
Search for more papers by this authorChun-Yu Huang
Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China
Search for more papers by this authorCorresponding Author
De-Sheng Liang
The State Key Laboratory of Medical Genetics of China, Central South University, Changsha, Hunan, China
Correspondence
Yong Zeng, Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China.
Email: [email protected]
and
De-Sheng Liang, The State Key Laboratory of Medical Genetics of China, Central South University, Changsha, Hunan, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Yong Zeng
Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China
Correspondence
Yong Zeng, Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China.
Email: [email protected]
and
De-Sheng Liang, The State Key Laboratory of Medical Genetics of China, Central South University, Changsha, Hunan, China.
Email: [email protected]
Search for more papers by this authorAbstract
Problem
We aimed to investigate the modulatory effects of vitamin D on peripheral blood cellular immune response in patients with recurrent miscarriage (RM).
Method of study
The effect of vitamin D on the number of peripheral blood cells, T helper 1 (Th1) cytokines, and NK cytotoxicity was measured in 99 women with RM.
Results
The percentage of CD19+ B cells and NK cytotoxicity at an effector-to-target cell (E:T) ratio of 50:1, 25:1, and 12.5:1 were significantly higher in the vitamin D insufficiency group (VDI) than in the vitamin D normal group (VDN) (P<.05 each). The proportion of TNF-α-expressing Th cells was significantly higher in the vitamin D deficiency group (VDD) than in VDN (P<.05). However, there were no significant differences between VDI and VDD. This dysregulation was significantly reduced with 1,25(OH)2D supplementation.
Conclusion
The data suggest that the abnormalities of cellular immune response were observed in RM patients with a low vitamin D level, which could be regulated to some extent with 1,25(OH)2D supplementation.
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